3.1.4.38: glycerophosphocholine cholinephosphodiesterase

This is an abbreviated version!
For detailed information about glycerophosphocholine cholinephosphodiesterase, go to the full flat file.

Word Map on EC 3.1.4.38

Reaction

sn-glycero-3-phosphocholine
+
H2O
=
glycerol
+
phosphocholine

Synonyms

L-3-glycerylphosphinicocholine cholinephosphohydrolase, Zn2+-glycerophosphocholine cholinphosphodiesterase, Zn2+-GPC cholinphosphodiesterase, p-nitrophenylphosphocholine cholinphosphodiesterase, Co2+-glycerophosphocholine cholinphosphodiesterase, glycerophosphocholine choline phosphodiesterase, alkaline lysosphingomyelinase, GPC-Cpde, glycosylphosphatidylinositol-anchored alkaline hydrolase, GPI-anchored alkaline hydrolase, GPC-CP, GPC-CP14, ENPP6, ectonucleotide pyrophosphatase/phosphodiesterase family member 6

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.4 Phosphoric-diester hydrolases
                3.1.4.38 glycerophosphocholine cholinephosphodiesterase

Inhibitors

Inhibitors on EC 3.1.4.38 - glycerophosphocholine cholinephosphodiesterase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-mercaptoethanol
-
-
3-mercaptobutanol
-
-
3-morpholinosydnonimine
-
-
ascorbate
-
oxidative inactivation of the Zn2+ -enzyme
carnitine
-
-
choline
-
competitive inhibitor
Co2+
80.6% inhibition at 2 mM
Cu2+
complete inhibition at 2 mM
cysteamine
-
-
dipropionylphosphatidylcholine
-
-
Fe2+
49.4% inhibition at 2 mM
hexyl-beta-glucoside
-
-
HO-radical-generator
-
5 mM H2O2 plus 5 mM KCl plus 0.5 units horseradish peroxidase
-
Mn2+
20.5% inhibition at 2 mM
p-nitrophenylphosphate
-
competitive inhibitor
p-Nitrophenylphosphorylcholine
-
competitive inhibitor
phosphocholine
-
-
PMSF
21.2% inhibition at 2 mM
tellurite
-
inhibitory effect is greater on the Zn2+ -enzyme
tellurium tetrachloride
-
potent competitive inhibitor
Tetranitromethane
-
-
thiocholine
-
inhibitory effect is greater on the Co2+ -enzyme
thioglycerol
-
-
Zn2+
99.6% inhibition at 2 mM
additional information
-