3.1.4.38: glycerophosphocholine cholinephosphodiesterase

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For detailed information about glycerophosphocholine cholinephosphodiesterase, go to the full flat file.

Reaction

Synonyms

alkaline lysosphingomyelinase, Co2+-glycerophosphocholine cholinphosphodiesterase, ectonucleotide pyrophosphatase/phosphodiesterase family member 6, ENPP6, glycerophosphocholine choline phosphodiesterase, glycosylphosphatidylinositol-anchored alkaline hydrolase, GPC-CP, GPC-CP14, GPC-Cpde, GPI-anchored alkaline hydrolase, L-3-glycerylphosphinicocholine cholinephosphohydrolase, p-nitrophenylphosphocholine cholinphosphodiesterase, Zn2+-glycerophosphocholine cholinphosphodiesterase, Zn2+-GPC cholinphosphodiesterase

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.4 Phosphoric-diester hydrolases

                3.1.4.38 glycerophosphocholine cholinephosphodiesterase

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Results	in table
3	Activating Compound
1049	AA Sequence
2	Application
1	CAS Registry Number
1	Cloned(Commentary)
1	Crystallization (Commentary)
1	Disease/ Diagnostics
9	General Information
30	Inhibitors
5	kcat/KM [mM/s]
2	Ki Value [mM]
16	KM Value [mM]
22	Localization
20	Metals/Ions
12	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
21	Organism
8	PDB ID
10	pH Optimum
5	pH Range
1	pH Stability
6	Posttranslational Modification
10	Purification (Commentary)
1	Reaction
1	Reaction Type
21	Reference
24	Source Tissue
5	Specific Activity [micromol/min/mg]
41	Substrates and Products (Substrate)
6	Subunits
21	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
2	Temperature Range [°C]
7	Temperature Stability [°C]
5	Turnover Number [1/s]

Disease

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Disease on EC 3.1.4.38 - glycerophosphocholine cholinephosphodiesterase

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DISEASE

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Multiple Sclerosis

Glycerylphosphocholine phosphocholine phosphodiesterase activity is reduced in multiple sclerosis plaques.

2165915

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