3.1.3.67: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase

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For detailed information about phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase, go to the full flat file.

Word Map on EC 3.1.3.67

3.1.3.67

3-kinase

rapamycin

mtor

tumorigenesis

prostate

metastasis

endothelial

luciferase

glioblastoma

tumour

glioma

carcinogenesis

endometrial

clinicopathological

pten-deficient

adenocarcinoma

colorectal

transwell

hamartoma

cowden

caspase-3

bcl-2

germline

cyclin

pik3ca

epithelial-mesenchymal

lncrnas

nsclc

microrna-21

phosphatidylinositol-3-kinase

tumor-suppressor

pten-induced

her2

phospho-akt

pink1

pi3k-akt

4,5-bisphosphate

macrocephaly

her2-positive

hamartomatous

endometrioid

ptdins3,4,5p3

phosphatidylinositol-4,5-bisphosphate

phosphoinositide-3-kinase

phosphoinositide-dependent

trastuzumab

phosphoinositide-3

analysis

drug development

everolimus

diagnostics

medicine

mirna-21

Reaction

1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Synonyms

1-phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase, MMAC1/TEP1, phosphatase and tensin homolog, phosphatase and tensin homologue, phosphatase and tensin homologue deleted on chromosome 10, phosphatidylinositol 3,4,5-trisphosphate-specific phosphatase, phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase, PI 3-phosphatase, PTEN, PTEN phosphatase, PTEN/MMAC, PTEN/MMAC1, SidF, TPIP, tumor suppressor PREN, voltage-sensing phosphatase, Voltage-sensing phosphoinositide phosphatase, VSP

ECTree

3 Hydrolases

3.1 Acting on ester bonds

3.1.3 Phosphoric-monoester hydrolases

3.1.3.67 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase

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Results	in table
5	Activating Compound
865	AA Sequence
6	Application
1	CAS Registry Number
39	Cloned(Commentary)
1	Crystallization (Commentary)
7238	Disease/ Diagnostics
2	Expression
7	General Information
2	General Stability
9	Inhibitors
3	KM Value [mM]
12	Localization
3	Metals/Ions
2	Molecular Weight [Da]
58	Natural Substrates/ Products (Substrates)
41	Organism
3	Pathway
20	PDB ID
2	pH Optimum
13	Posttranslational Modification
90	Protein Variants
6	Purification (Commentary)
1	Reaction
8	Reaction Type
41	Reference
79	Source Tissue
17	Specific Activity [micromol/min/mg]
87	Substrates and Products (Substrate)
2	Subunits
46	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 3.1.3.67 - phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase

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4-hydroxynonenal

Mus musculus

731861

Ca2+

Bos taurus

in presence of 1 mM Mg2+, slight activation up to 0.01 mM, significant inhibition above 0.1 mM

25140

H2O2

Homo sapiens

H2O2 reversibly inhibits PTEN activity by covalently linking Cys-71 to Cys-124, inhibition partially reverses by inclusion of 100 mM dithiothreitol to the buffer

694916

Laminin

Rattus norvegicus

laminin medium induces PTEN upregulation decreases transcription factor Sp1-binding activity

690780

Mg2+

Bos taurus

divalent cation required, maximal activition at 1 mM, inhibition above 1 mM

25140

phosphatidylserine

Bos taurus

0.2 mM, 75% loss of activity

25140

reactive oxygen species

Homo sapiens

oxidation of the active site cysteine by reactive oxygen species inhibits PTEN

694495

additional information

2 entries