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3.1.3.5: 5'-nucleotidase

This is an abbreviated version!
For detailed information about 5'-nucleotidase, go to the full flat file.

Word Map on EC 3.1.3.5

Reaction

A 5'-ribonucleotide
+
H2O
=
a ribonucleoside
 +
phosphate

Synonyms

5'-adenylic phosphatase, 5'-AMP nucleotidase, 5'-AMPase, 5'-ectonucleotidase, 5'-mononucleotidase, 5'-NT, 5'-NT-1, 5'-NT-2, 5'-NT-3, 5'-NT-4, 5'-nucleotidase, 5'-nucleotidase A, 5'-nucleotidase I, 5'-nucleotidase II, 5'Nase, 5'nucleotidase, 5nA, 5NT, adenosine 5'-monophosphatase, adenosine 5'-phosphatase, adenosine monophosphatase, AMP phosphatase, AMP phosphohydrolase, AMP-selective 5'-nucleotidase, AMPase, c-N-I, c-N-II, Cant1, CD73, CD73 antigen, CD73/ecto-5'-nucleotidase, class C acid phosphatase, cN-I, cN-IA, cN-II, cN-III, cNI, cNII, cNIIIB nucleotidase, cytoplasmic 5'-nucleotidase II, cytoplasmic 5'-nucleotidase II (IMP-selective or GMP/IMP-selective), cytoplasmic 5'-nucleotidase III, cytoplasmic 5'-nucleotidase-I (AMP-selective), cytosolic 5'-nucleotidase, cytosolic 5'-nucleotidase II, cytosolic 5'-nucleotidase/phosphotransferase, E-5'-Nu, e-5NT, e-N, e5'-NT, e5'NT, ecto 5'-NT, ecto 5'-nucleotidase, ecto-5' nucleotidase, ecto-5'-NT, ecto-5'-NT/CD73, ecto-5'-nucleotidase, ecto-5'-nucleotidase/CD73, ecto-5'nucleotidase, ecto-5-NT, ecto-5-nucleotidase, ecto-nucleotidase, ectonuceotidase, ectonucleotidase, ectonucleotidase CD73, eN, eNs, eNT, GA-AMPase, high Km 5'-nucleotidase, high-Km 5'-NT, hppA gene product, IMP 5'-nucleotidase, IMP-GMP 5'-nucleotidase, IMP-GMP specific nucleotidase, IMP-specific, high Km 5'-nucleotidase, IMP/GMP selective 5'-NT, Isn1, membrane-bound 5'-nucleotidase, More, NMN 5'-nucleotidase, NT5C3A, NT5E, P5'N-1, Phm8, Pho5, PM-AMPase, PN-1, PN-I, purine 5'-NT, purine 5'-nucleotidase, pyrimidine 5'-nucleotidase, Sdt1, snake venom 5'-nucleotidase, soluble calcium-activated nucleotidase 1, thymidine monophosphate nucleotidase, type II cytosolic 5'-nucleotidase, UMPase, UMPH-1, uridine 5'-nucleotidase, uridine monophosphate hydrolase-1, UshA, XF_2089, YutF

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.3 Phosphoric-monoester hydrolases
                3.1.3.5 5'-nucleotidase

IC50 Value

IC50 Value on EC 3.1.3.5 - 5'-nucleotidase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.004 - 0.027
1-amino-4-bromo-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid
0.00729 - 0.0137
1-pentyl-1H-benzofuro[3,2-b]pyrrolo[3,2-e]pyridine-3-carbonitrile
0.00543 - 0.00921
1-tert-butyl-1H-benzofuro[3,2-b]pyrrolo[3,2-e]pyridine-3-carbonitrile
0.1
1-tert-butyl-5-chloro-6-(2-hydroxy-5-methylphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile
0.1
1-tert-butyl-5-chloro-6-(2-hydroxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile
0.1
2-(3-methyl-1,5-diphenyl-1H-pyrazolo[3,4-b]pyridin-6-yl)phenol
0.00326 - 0.0235
2-(5-chloro-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)-4-methylphenol
0.00203 - 0.00263
2-(5-chloro-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)-5-methoxyphenol
0.00032 - 0.1
2-(5-chloro-3-methyl-1-p-tolyl-1H-pyrazolo[3,4-b]pyridin-6-yl)-4-methylphenol
0.00346 - 0.0111
2-(5-chloro-3-methyl-1-p-tolyl-1H-pyrazolo[3,4-b]pyridin-6-yl)phenol
0.00573 - 0.1
2-(5-chloro-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridin-6-yl)-4-methylphenol
0.00067 - 0.0105
2-(5-chloro-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridin-6-yl)-5-methoxyphenol
0.1
2-(5-chloro-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridin-6-yl)phenol
0.00077
2-chloro-N-(pyridin-4-yl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0112
2-methyl-N-(pyridin-4-yl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.00038
2-nitro-N-(pyridin-4-yl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.00041
2-phenyl-N-(pyridin-4-yl)acetamide
Homo sapiens
pH and temperature not specified in the publication
0.00307
3,4,5-trimethoxy-N-(pyridin-4-yl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.00554
3,5-dinitro-N-(pyridine-4-yl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.00463 - 0.1
3,8-dimethyl-1-p-tolyl-1H-benzofuro[3,2-b]pyrazolo[4,3-e]pyridine
0.00566 - 0.1
3,8-dimethyl-1-phenyl-1H-benzofuro[3,2-b]pyrazolo[4,3-e]pyridine
0.0102
3-(2-(3,4,5-trimethoxybenzylideneamino)thiazol-4-yl)-2Hchromen-2-one
Homo sapiens
-
at pH 7.4 and 37°C
0.00223
3-(2-(3-chlorobenzylideneamino)thiazol-4-yl)-2H-chromen-2-one
Homo sapiens
-
at pH 7.4 and 37°C
0.00041
3-(2-(3-methoxy-4-phenoxybenzylideneamino)thiazol-4-yl)-2H-chromen-2-one
Homo sapiens
-
at pH 7.4 and 37°C
0.00025
3-(2-(3-nitrobenzylideneamino)thiazol-4-yl)-2H-chromen-2-one
Homo sapiens
-
at pH 7.4 and 37°C
0.000438
3-(2-(4-bromobenzylideneamino)thiazol-4-yl)-2H-chromen-2-one
Homo sapiens
-
at pH 7.4 and 37°C
0.00028
3-(2-(4-chlorobenzylideneamino)thiazol-4-yl)-2H-chromen-2-one
Homo sapiens
-
at pH 7.4 and 37°C
0.00515
3-(2-(4-fluorobenzylideneamino)thiazol-4-yl)-2H-chromen-2-one
Homo sapiens
-
at pH 7.4 and 37°C
0.00092
3-(2-(furan-2-ylmethyleneamino)thiazol-4-yl)-2H-chromen-2-one
Homo sapiens
-
at pH 7.4 and 37°C
0.00411
3-chloro-N-(pyridin-4-yl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.00732 - 0.1
3-methyl-1-p-tolyl-1H-benzofuro[3,2-b]pyrazolo[4,3-e]pyridine
0.00645 - 0.0111
3-methyl-1-phenyl-1H-benzofuro[3,2-b]pyrazolo[4,3-e]pyridine
0.00025
3-methyl-N-(pyridin-4-yl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.00109
3-nitro-N-(pyridin-4-yl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0061 - 0.0443
4-(3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonic acid
0.00029
4-chloro-N-(pyridin-4-yl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.00171
4-methyl-N-(pyridin-4-yl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.00042
4-nitro-N-(pyridin-4-yl)benzamide
Homo sapiens
pH and temperature not specified in the publication
0.0878
5'-deoxy-7-methyl-5'-(4-phosphono-1H-pyrazol-1-yl)guanosine
Homo sapiens
-
at pH 7.5 and 30°C
0.1
5-chloro-3-methyl-1-phenyl-6-(2-propoxyphenyl)-1H-pyrazolo[3,4-b]pyridine
0.1
5-chloro-6-(2-(heptyloxy)phenyl)-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine
0.1
5-chloro-6-(2-hydroxy-5-methylphenyl)-2-phenyl-2H-pyrazolo[3,4-b]pyridin-3-ol
0.0103 - 0.1
5-chloro-6-(2-hydroxyphenyl)-2-phenyl-2H-pyrazolo[3,4-b]pyridin-3-ol
0.0184 - 0.1
5-chloro-6-(2-methoxyphenyl)-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine
0.02
5-ethynyldideoxyuridine
Homo sapiens
-
-
0.00132 - 0.0104
6-amino-4-hydroxynaphthalene-2-sulfonic acid
0.00352 - 0.0171
6-chloro-7-(2-hydroxy-5-methylphenyl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione
0.00129 - 0.00214
6-chloro-7-(2-hydroxyphenyl)-1-methylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione
0.00521 - 0.1
6-chloro-7-(2-hydroxyphenyl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione
0.0124 - 0.1
7-methoxy-3-methyl-1-phenyl-1H-benzofuro[3,2-b]pyrazolo[4,3-e]pyridine
0.0024
concanavalin A
Naja naja
-
in 50 mM Tris-HCl buffer, pH 7.4, 10 mM MgCl2, 50 mM NaCl, 10 mM KCl, at 37°C
-
0.00792
N-(pyridin-4-yl)furan-2-carboxamide
Homo sapiens
pH and temperature not specified in the publication
0.0453
quercetin
Homo sapiens
-
pH 7.4, 37°C
0.0421 - 0.0773
sulfamic acid
0.0421
Sulfanilic acid
Homo sapiens
pH and temperature not specified in the publication
0.18
vanillic acid
Naja naja
-
in 50 mM Tris-HCl buffer, pH 7.4, 10 mM MgCl2, 50 mM NaCl, 10 mM KCl, at 37°C