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3.1.3.4: phosphatidate phosphatase

This is an abbreviated version!
For detailed information about phosphatidate phosphatase, go to the full flat file.

Word Map on EC 3.1.3.4

Reaction

a 1,2-diacylglycerol 3-phosphate
+
H2O
=
a 1,2-diacyl-sn-glycerol
 +
phosphate

Synonyms

3-sn-phosphatidate phosphohydrolase, acid phosphatidyl phosphatase, APP1, DGPP phosphatase, diacylglycerol diphosphate phosphatase, diacylglycerol pyrophosphate phosphatase, DPP1, Dpp1p, DPPL1, DPPL2, Dri-42, Dri42, ecto-PAPase, ecto-phosphatidic acid phosphohydrolase, EtLPP1, EtLPP2, EtLPP3, Germ cell guidance factor, Ippalpha, Ippbeta, Laza, Lazaro phosphatidic acid phosphatase, lipid phosphate phosphatase, lipid phosphate phosphatase 1, lipid phosphate phosphatase 3, lipid phosphate phosphatase-1, lipid phosphate phosphatase-2, lipid phosphate phosphatase-3, lipid phosphate phosphatase-related protein, lipid phosphate phosphatase-related protein type 1, lipid phosphate phosphatase-related protein type 2, lipid phosphate phosphatase-related protein type 3, lipid phosphate phosphatase-related protein type 4, lipid phosphate phosphohydrolase, lipidphosphatase-related protein 1, lipin, lipin 1, lipin 1beta, lipin 2, lipin 3, lipin Pah1p/Smp2p, lipin-1, lipin-1alpha, lipin-1beta, lipin-1gamma, lipin-2, lipin-3, Lipin1, lipin1alpha, lipin1beta, LLP1, LLP2, LPIN1, LPP, LPP-1, LPP1, LPP1-encoded lipid phosphatase, Lpp1p, LPP2, LPP3, LPPR2, LPR, LPR-1, LPR-2, LPR-3, LPR-4, LPR1, Mg2+-dependent PA1 phosphatase, Mg2+-dependent phosphatidate phosphatase, Mg2+-dependent phosphatidic acid phosphatase, More, PA phosphatase, PA-P, PA-PSP, PA2 phosphatase, PAH, pah1, Pah1p, Pah1p/Smp2p, PAH2, PAP, PAP-1, PAP-2, PAP-2b, PAP1, PAP2, PAP2-like protein, PAP2a, PAP2d, PAP2L2, PAP3, PAPase, phosphatidate phosphatase, phosphatidate phosphatase type-1, phosphatidate phosphatase-1, phosphatidate phosphohydrolase, phosphatidic acid phosphatase, phosphatidic acid phosphatase 2a, phosphatidic acid phosphatase type 2, phosphatidic acid phosphatase-1, phosphatidic acid phosphohydrolase, phosphatidic acid phosphohydrolase 1, phosphatidic acid phosphohydrolase-1, plasticity related gene 1, plasticity related gene 3, plasticity related gene 4, presqualene diphosphate phosphatase, PRG-1, PRG-3, PRG3, RHA1_ro00075, SCO1102, SCO1753, SMP2, type 2b phosphatidic acid phosphatase, wun, wun2, WunD, Wunen, Wunen protein, wunen-2, Wunen2

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.3 Phosphoric-monoester hydrolases
                3.1.3.4 phosphatidate phosphatase

Expression

Expression on EC 3.1.3.4 - phosphatidate phosphatase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
both lipin 2 mRNA and protein expression are significantly induced by food deprivation. Lipin 2 knockdown leads to a compensatory increase in Lpin3 mRNA expression, especially in fld hepatocytes
-
downregulation of LPIN-1 by RNAi
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enzyme activity is induced during lipogenesis
epidermal growth factor increases LPP3 mRNA in HeLa cells. Androgen increases LPP1 mRNA in adenocarcinoma cells
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expression is induced throughout growth and the induction in the stationary phase is stimulated by inositol supplementation. The Ino2p/Ino4p/Opi1p regulatory circuit and transcription factors Gis1p and Rph1p mediated this regulation
expression of lipin 1beta in viscera adipose tissue does not correlate with PPARG, LPL, LIPE, adiponectin and SLC2A4 gene expression
-
hepatic lipin-1 expression is selectively repressed by insulin
hepatic lipin-1 expression is selectively stimulated by glucocorticoids. The expression of lipin-1 is markedly up-regulated under stress conditions
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hepatic lipin-1 expression is selectively stimulated by glucocorticoids. The expression of lipin-1 is markedly upregulated under stress conditions
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hepatic lipin-1 expression levels and VLDL secretion both increase in obese individuals following gastric bypass surgery
-
homozygous T-DNA-tagged mutants of PAH1 and PAH2 do not express their respective full-length mRNAs
-
in polycystic ovary syndrome patients, lipin 1beta expression in subcutaneous and visceral adipose tissue depots is lower than in controls. In polycystic ovary syndrome patients, visceral adipose lipin 1beta expression correlates negatively with homeostasis model assessment-insulin resistance, body mass index and waist circumference. Subcutaneous lipin 1beta expression in polycystic ovary syndrome patients correlates negatively with body mass index, waist circumference and plasma triglycerides
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in the 3T3-L1 cell line, lipin-2 protein levels are highest in preadipocytes
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in the 3T3-L1 cell line, lipin-2 protein levels decline dramatically as adipocyte differentiation proceeds to become virtually undetectable in mature adipocytes, when lipin-1 is expressed at high levels
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lipin 1 knockdown by shRNA, decline in lipin 1 expression with increasing obesity in ob/ob mice
-
lipin 2 protein content is increased in fld liver independent of changes in steady-state Lpin2 mRNA levels. Lipin 2 is dynamically regulated in liver but is not a target gene of peroxisome proliferator-activated receptorgamma-coactivator 1alpha
-
lipin-1 gene expression is regulated in a glucocorticoid receptor-dependent manner
lipin-1A and -B expression levels increase dramatically during differentiation of 3T3-L1 preadipocytes to mature adipocytes. Glucocorticoids are the stimulus for the induction of lipin-1 expression in differentiating adipocytes. Lpin1 glucocorticoid response element binds to the glucocorticoid receptor and leads to transcriptional activation in adipocytes and hepatocytes. The Lpin1 promoter directly binds the glucocorticoid receptor in a hormone-dependent manner. Dexamethasone rapidly induces lipin-1 gene expression in a dose-dependent manner, it acts at the level of lipin-1 gene transcription. In response to 0.001 mM dexamethasone treatment, lipin-1B mRNA levels increase as early as 1 h, and lipin-1A levels after 2 h, whereby lipin-1B levels peak with a 7fold induction at 2 h and lipin-1A levels increase to a maximum of 3fold above baseline and remain elevated near this level throughout 24 h. Adipose tissue lipin-1 expression is increased in conditions associated with increased local glucocorticoid concentrations in vivo
-
lipin-2 is most prominently expressed in liver, where levels are much higher than lipin-1, and also in kidney, lung, gastrointestinal tract, and specific regions of the brain. Fasting induces hepatic lipin-1 by 25fold and lipin-2 by 5fold. Lipin-2 is also expressed in circulating red blood cells and sites of lymphopoiesis, like bone marrow, thymus, and spleen
lipin1 is induced in the late stages of adipocyte differentiation. During the maturation of adipocytes, the increase of lipin1alpha is less than that of lipin1beta. CCAAT/enhancer-binding protein alpha directly controls the expression of lipin1, overexpression of CCAAT/enhancer-binding protein alpha activates the lipin1 promoter (from nt -1340 to -524) about 6fold over the basal activity in a transient transfection assay
-
LPIN1 mRNA does not change in cells transfected with SREBP-2 siRNA. Both the sterol regulatory element and the nuclear factor Y-binding site are important in the regulation of LPIN1 transcription
-
LPIN1 mRNA levels decrease significantly after transfection with LPIN1 siRNA. LPIN1 mRNA levels are reduced to ca. 0.6fold after transfection with SREBP-1 siRNA
-
LPP2 expression is down-regulated by abscisic acid (0.01 mM)
-
LPP3 expression is negatively correlated with vascular endothelial growth factor expression
LPP3 expression is up-regulated by abscisic acid (0.01 mM)
-
mRNA in rat triceps muscle is increased by approximately 2fold after an acute bout of endurance swimming exercise. Lipin-1 mRNA expression in the triceps muscle, compared with that of the control muscle, significantly increases by 85% and 71% immediately after 3- and 6-h swimming exercise, respectively. Lipin-1 mRNA expression in rat triceps muscle is significantly elevated at 6 h after subcutaneous injections of 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) by 82% or clenbuterol by 3fold, which are 5'-AMP-activated protein kinase and beta2-adrenergic receptor activators, respectively
-
no difference in lipin-alpha mRNA expression between Rongchang pigs with high or low intramuscular fat
positive correlation between lipin-1 expression levels in adipose tissue and insulin sensitivity in obese subjects with normal or impaired glucose tolerance and in healthy young men. Lipin-1 expression is induced in adipocytes by insulin-sensitizing drugs such as thiazolidinediones and harmine. Lipin-2 expression in human adipose tissue
-
RNAi against lipin 2 markedly reduces PAP-1 activity in hepatocytes from both wild-type and fld mice and suppresses triglyceride synthesis under conditions of high fatty acid availability
-
RNAi downregulation of lpin-1
sterol regulatory element-binding protein 1 (SREBP-1) and nuclear factor Y are necessary for the activation of LPIN1 transcription. Induction of the LPIN1 gene by sterol depletion. The region between nucleotides -2428 and -2378 of the LPIN1 promoter contains sequences that mediate the induction of LPIN1 by sterol depletion. LPIN1 mRNA levels are induced 3.3fold in lipoprotein-deficient serum medium relative to those in sterol-containing medium. In statin-containing medium, LPIN1 mRNA increases 7.2fold
-
subcutaneous lipin 1beta expression in polycystic ovary syndrome patients correlates positively with high density lipoprotein-cholesterol. Expression of lipin 1beta in subcutaneous adipose tissue correlates positively with PPARG, LPL, LIPE, adiponectin and SLC2A4 gene expression
-
the enzyme activity is induced at the early exponential phase
the longissimus dorsi muscle of Rongchang obese pigs have a higher level of mRNA expression for lipin1 and its isoforms than PIC lean pigs. Rongchang pigs with higher intramuscular fat content have a higher lipin1 and lipin-beta mRNA expression in longissimus dorsisi muscle than Rongchang pigs with lower intramuscular fat content
total lipin-1 mRNA expression is significantly induced by dexamethasone in human preadipocytes and differentiated adipocytes
-
wild type cells supplemented with palmitoleic acid exhibit an induction in phosphatidate phosphatase activity
Wunens are normally expressed in somatic tissues that germ cells avoid
-