3.1.3.4: phosphatidate phosphatase
This is an abbreviated version!
For detailed information about phosphatidate phosphatase, go to the full flat file.
Word Map on EC 3.1.3.4
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3.1.3.4
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phospholipid
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triacylglycerols
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phospholipase
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lipins
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phosphatidylcholine
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triglyceride
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propranolol
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adipose
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lysophosphatidic
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glycerolipids
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acyltransferase
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adipocyte
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lipogenesis
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lipogenic
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sphingosine
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pkc
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steatosis
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lipodystrophy
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rhabdomyolysis
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cytidylyltransferase
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mg2+-independent
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sphingosine-1-phosphate
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phosphatidylethanol
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diradylglycerol
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bromoenol
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transphosphatidylation
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kennedy
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cdp-diacylglycerol
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sn-glycerol
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argonaut
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1,2-diacylglycerol
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sphingoid
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srebf1
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dgats
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pirnas
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glycerolphosphate
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pc-plc
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plectonema
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ctp:phosphocholine
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plasticity-related
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acaca
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prophenoloxidase
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cholinephosphotransferase
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phosphatidylcholine-specific
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sn-glycerol-3-phosphate
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medicine
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analysis
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drug development
- 3.1.3.4
- phospholipid
- triacylglycerols
- phospholipase
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lipins
- phosphatidylcholine
- triglyceride
- propranolol
- adipose
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lysophosphatidic
- glycerolipids
- acyltransferase
- adipocyte
-
lipogenesis
-
lipogenic
- sphingosine
- pkc
- steatosis
- lipodystrophy
- rhabdomyolysis
- cytidylyltransferase
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mg2+-independent
- sphingosine-1-phosphate
- phosphatidylethanol
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diradylglycerol
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bromoenol
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transphosphatidylation
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kennedy
- cdp-diacylglycerol
- sn-glycerol
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argonaut
- 1,2-diacylglycerol
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sphingoid
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srebf1
-
dgats
-
pirnas
- glycerolphosphate
- pc-plc
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plectonema
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ctp:phosphocholine
-
plasticity-related
- acaca
-
prophenoloxidase
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cholinephosphotransferase
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phosphatidylcholine-specific
- sn-glycerol-3-phosphate
- medicine
- analysis
- drug development
Reaction
Synonyms
3-sn-phosphatidate phosphohydrolase, acid phosphatidyl phosphatase, APP1, DGPP phosphatase, diacylglycerol diphosphate phosphatase, diacylglycerol pyrophosphate phosphatase, DPP1, Dpp1p, DPPL1, DPPL2, Dri-42, Dri42, ecto-PAPase, ecto-phosphatidic acid phosphohydrolase, EtLPP1, EtLPP2, EtLPP3, Germ cell guidance factor, Ippalpha, Ippbeta, Laza, Lazaro phosphatidic acid phosphatase, lipid phosphate phosphatase, lipid phosphate phosphatase 1, lipid phosphate phosphatase 3, lipid phosphate phosphatase-1, lipid phosphate phosphatase-2, lipid phosphate phosphatase-3, lipid phosphate phosphatase-related protein, lipid phosphate phosphatase-related protein type 1, lipid phosphate phosphatase-related protein type 2, lipid phosphate phosphatase-related protein type 3, lipid phosphate phosphatase-related protein type 4, lipid phosphate phosphohydrolase, lipidphosphatase-related protein 1, lipin, lipin 1, lipin 1beta, lipin 2, lipin 3, lipin Pah1p/Smp2p, lipin-1, lipin-1alpha, lipin-1beta, lipin-1gamma, lipin-2, lipin-3, Lipin1, lipin1alpha, lipin1beta, LLP1, LLP2, LPIN1, LPP, LPP-1, LPP1, LPP1-encoded lipid phosphatase, Lpp1p, LPP2, LPP3, LPPR2, LPR, LPR-1, LPR-2, LPR-3, LPR-4, LPR1, Mg2+-dependent PA1 phosphatase, Mg2+-dependent phosphatidate phosphatase, Mg2+-dependent phosphatidic acid phosphatase, More, PA phosphatase, PA-P, PA-PSP, PA2 phosphatase, PAH, pah1, Pah1p, Pah1p/Smp2p, PAH2, PAP, PAP-1, PAP-2, PAP-2b, PAP1, PAP2, PAP2-like protein, PAP2a, PAP2d, PAP2L2, PAP3, PAPase, phosphatidate phosphatase, phosphatidate phosphatase type-1, phosphatidate phosphatase-1, phosphatidate phosphohydrolase, phosphatidic acid phosphatase, phosphatidic acid phosphatase 2a, phosphatidic acid phosphatase type 2, phosphatidic acid phosphatase-1, phosphatidic acid phosphohydrolase, phosphatidic acid phosphohydrolase 1, phosphatidic acid phosphohydrolase-1, plasticity related gene 1, plasticity related gene 3, plasticity related gene 4, presqualene diphosphate phosphatase, PRG-1, PRG-3, PRG3, RHA1_ro00075, SCO1102, SCO1753, SMP2, type 2b phosphatidic acid phosphatase, wun, wun2, WunD, Wunen, Wunen protein, wunen-2, Wunen2
ECTree
3.1.3.4 phosphatidate phosphataseAdvanced search results
results (
results (Activating Compound
Activating Compound on EC 3.1.3.4 - phosphatidate phosphatase
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ACTIVATING COMPOUND 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
epinephrine
promotes dephosphorylation of lipin, but has no effect on PAP activity, markedly increases amounts of lipin and PAP activity in microsomes
Insulin
increases the phosphorylation of multiple sites, markedly increases the amounts of lipin and PAP activity in the soluble fraction, effects of insulin are attenuated by rapamycin or by inhibiting PI 3 kinase
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phosphatidylglycerol
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essential for optimal activity, responsible for a better solubilization of the substrate by CHAPS. The possibility of a specidic role as aphysiological activator cannot be ruled out
polyamines
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activate in presence of Mg2+, no activation in absence of Mg2+
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putrescine
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activate in presence of Mg2+, no activation in absence of Mg2+. Effective at 2-5 mM
sphingosine 1-phosphate
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activates overall cell lipid phosphate phosphatase activities by about 13%
Tween 20
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increases hydrolysis of phosphatidate bound to microsomal membrane or phosphatidate in sonicated dispersion of organic solvent-disrupted microsomes, little effect on hydrolysis of phosphatidate dispersed in sonicated microsomal lipid
cardiolipin
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PAH1-encoded PAP activity is enhanced by the phospholipids CDP-diacylglycerol, phosphatidylinositol, and cardiolipin
CDP-diacylglycerol
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PAH1-encoded PAP activity is enhanced by the phospholipids CDP-diacylglycerol, phosphatidylinositol, and cardiolipin
oleic acid
promotes dephosphorylation of lipin, but has no effect on PAP activity, markedly increases amounts of lipin and PAP activity in microsomes
phosphatidylinositol
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PAH1-encoded PAP activity is enhanced by the phospholipids CDP-diacylglycerol, phosphatidylinositol, and cardiolipin
spermidine
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activates in presence of Mg2+, no activation in absence of Mg2+. Effective at 1 mM
spermine
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activates in presence of Mg2+, no activation in absence of Mg2+. Effective at 0.5-1 mM, inhibitory at higher concentrations
Triton X-100
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plasma membrane-associated activity is absolutely dependent on detergent
Triton X-100
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5.5fold increase in activity with membrane-bound phosphatidic acid
Triton X-100
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the 45000 Da enzyme form shows maximal activity at 5 mM
Triton X-100
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the 45-kDa and 104-kDa enzyme forms are dependent on Triton X-100 for activity
Triton X-100
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activates by forming a mixed micelle with the lipid substrate PA, providing a membrane mimic for catalysis
additional information
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light regulation of the lipid phosphate phosphatases, overview
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additional information
treatment of HeLa cells with the epidermal growth factor leads to 3fold increased LPP-3 expression, while LPP-1 expression is unaffected, LPP-1 expression is increased in prostate adenocarcinoma cells treated with androgens
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additional information
treatment of HeLa cells with the epidermal growth factor leads to 3fold increased LPP-3 expression, while LPP-1 expression is unaffected, LPP-1 expression is increased in prostate adenocarcinoma cells treated with androgens
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additional information
treatment of HeLa cells with the epidermal growth factor leads to 3fold increased LPP-3 expression, while LPP-1 expression is unaffected, LPP-1 expression is increased in prostate adenocarcinoma cells treated with androgens
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additional information
treatment of HeLa cells with the epidermal growth factor leads to 3fold increased LPP-3 expression, while LPP-1 expression is unaffected, LPP-1 expression is increased in prostate adenocarcinoma cells treated with androgens
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additional information
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p73beta binding to DNA is essential for PAP2a expression
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additional information
regulation of filopodia by LPR1 is not mediated by cdc42 or Rif, and is independent of the Arp2/3 complex
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additional information
fasting increases Mg2+-dependent PAP activity in livers from wild type animals by 2fold
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additional information
insulin increases the phosphorylation of multiple sites e.g. at Ser106, insulin and epinephrine control lipin primarily by changing localization rather than intrinsic PAP activity, overview
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additional information
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hepatic lipin 2 protein content is markedly increased by lipin 1 deficiency, food deprivation, and obesity, often independent of changes in steady-state mRNA levels. Fasting induces expression of Lpin1 and Lpin2 in wild-type and PGC-1alpha-deficient mice
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additional information
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hyperactivated TORC2 enhances expression of lipin1. Diet-induced or genetic obesity increases LIPIN1 expression in mouse liver, and TORC2 is responsible for its transcriptional activation
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additional information
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increasing the catalytic activity of LPP1 decreases the pertussis toxin-sensitive stimulation of fibroblast migration by lyso-phosphatidic acid and an lyso-phosphatidic acid-receptor agonist, that can not be dephosphorylated
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additional information
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expression of the DPP1 gene, which encodes DGPP phosphatase, is induced by zinc depletion, by inositol supplementation, and when cells enter the stationary phase, induction by zinc depletion is mediated by the transcription factor Zap1p, which binds to a zinc-responsive element in the DPP1 promoter
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additional information
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the transcription factor Zap1p binds the DPP1 promoter and induces the expression of DGPP phosphatase, stress condition of zinc depletion induces DPP1 expression
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additional information
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dephosphorylation of lipin Pah1p by the Nem1p-Spo7p complex enables the amphipathic helix to anchor Pah1p onto the nuclear/endoplasmic reticulum membrane allowing the production of diacylglycerol for lipid biosynthesis
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additional information
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the enzyme expression is drought-stimulated. Transcripts accumulate in response to water deficit, including progressive dehydration of whole plants and rapid desiccation of detached leaves. The isozymes are not affected by wounding or by treatment with jasmonic acid
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