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3.1.3.3: phosphoserine phosphatase

This is an abbreviated version!
For detailed information about phosphoserine phosphatase, go to the full flat file.

Word Map on EC 3.1.3.3

Reaction

O-phospho-L(or D)-serine
+
H2O
=
L(or D)-serine
+
phosphate

Synonyms

3-phosphoserine phosphatase, BSU04700, BSU04740, BSU34110, CTD phosphatase fcp1, HPSP, iPSP, iPSP1, iPSP2, L-phosphoserine phosphatase, metal-independent phosphoserine phosphatase, metal-independent PSP, More, O-phosphoserine phosphohydrolase, phosphatase, phosphoserine, phosphoserine phosphatase, phosphoserine phosphatase RsbP, phosphoserine phosphatase RsbU, phosphoserine phosphatase RsbX, phosphoserine:homoserine phosphotransferase, PP1, PSP, PSP1, pspA, PSPase, pspB, PSPH, RsbP, RsbU, RsbX, SerB, SerB PG0653, SerB2, SerB653, serine/threonine protein phosphatase, sigma-B negative effector, StP, THrH, TON_1161, yvfP

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.3 Phosphoric-monoester hydrolases
                3.1.3.3 phosphoserine phosphatase

Reference

Reference on EC 3.1.3.3 - phosphoserine phosphatase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Vidal, Y.; Cassaigne, A.; Neuzil, E.
Interactions of aminophosphonates with rat liver phosphoserine phosphatase
Biochem. Soc. Trans.
13
788-789
1985
Rattus norvegicus
-
Manually annotated by BRENDA team
Garnant, M.K.; Stauffer, G.V.
Construction and analysis of plasmids containing the Escherichia coli serB gene
Mol. Gen. Genet.
193
72-75
1984
Escherichia coli
Manually annotated by BRENDA team
Paoli, A.; Guiraud, P.; Brunel, C.
O-Phosphoserine phosphatase from bovine brain and kidney. High molecular weight forms occurring during the purification
Biochim. Biophys. Acta
370
487-497
1974
Bos taurus
Manually annotated by BRENDA team
Schmidt, L.S.; Sojka, G.A.
Enzymes of serine biosynthesis in Rhodopseudomonas capsulata
Arch. Biochem. Biophys.
159
475-482
1973
Rhodobacter capsulatus
Manually annotated by BRENDA team
Bridgers, W.F.
Purification of mouse brain phosphoserine phosphohydrolase and phosphotransferase
Arch. Biochem. Biophys.
133
201-207
1969
Mus musculus
Manually annotated by BRENDA team
Knox, W.E.; Herzfeld, A.; Hudson, J.
Phosphoserine phosphatase distribution in normal and neoplastic rat tissues
Arch. Biochem. Biophys.
132
397-403
1969
Rattus norvegicus
Manually annotated by BRENDA team
Bridgers, W.F.
Mouse brain phosphoserine phosphohydrolase and phosphotransferase
J. Biol. Chem.
242
2080-2085
1967
Mus musculus
Manually annotated by BRENDA team
Byrne, W.L.
Glucose 6-phosphatase and phosphoserine phosphatase
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
5
73-78
1961
Gallus gallus, Rattus norvegicus
-
Manually annotated by BRENDA team
Kearney, P.; Holloway, B.W.
Regulation and routes of biosynthesis of serine and arginine in Methylophilus methylotrophus AS1
FEMS Microbiol. Lett.
42
109-112
1987
Methylophilus methylotrophus, Rattus norvegicus
-
Manually annotated by BRENDA team
Neuhaus, F.C.; Byrne, W.L.
Metabolism of phosphoserine. II. Purification and properties of O-phosphoserine phosphatase
J. Biol. Chem.
234
113-121
1959
Gallus gallus
Manually annotated by BRENDA team
Walton, N.J.; Woolhouse, H.W.
Enzymes of serine and glycine metabolism in leaves and non-photosynthetic tissues of Pisum sativum L.
Planta
167
119-128
1986
Pisum sativum
Manually annotated by BRENDA team
Germano, G.J.; Andersen, K.E.
Serine biosynthesis in Desulfovibrio desulfuricans
J. Bacteriol.
99
893-894
1969
Desulfovibrio desulfuricans
Manually annotated by BRENDA team
Ho, C.L.; Noji, M.; Saito, K.
Plastidic pathway of serine biosynthesis. Molecular cloning and expression of 3-phosphoserine phosphatase from Arabidopsis thaliana
J. Biol. Chem.
274
11007-11012
1999
Arabidopsis thaliana (O82796), Arabidopsis thaliana
Manually annotated by BRENDA team
Shetty, V.; Shetty, K.T.
Phosphoserine phosphatase of human brain: partial purification, characterization, regional distribution, and effect of certain modulators including psychoactive drugs
Neurochem. Res.
16
1203-1210
1991
Homo sapiens
-
Manually annotated by BRENDA team
Wood, P.L.; Hawkinson, J.E.; Goodenough, D.B.
Formation of D-serine from L-phosphoserine in brain synaptosomes
J. Neurochem.
67
1485-1490
1996
Rattus norvegicus
Manually annotated by BRENDA team
Hawkinson, J.E.; Acosta-Burruel, M.; Ta, N.D.; Wood, P.L.
Novel phosphoserine phosphatase inhibitors
Eur. J. Pharmacol.
337
315-324
1997
Rattus norvegicus
Manually annotated by BRENDA team
Peeraer, Y.; Rabijns, A.; Verboven, C.; Collet, J.F.; Van Schaftingen, E.; De Ranter, C.
Purification, crystallization and preliminary X-ray diffraction analysis of human phosphoserine phosphatase
Acta Crystallogr. Sect. D
58
133-134
2002
Homo sapiens
Manually annotated by BRENDA team
Peeraer, Y.; Rabijns, A.; Verboven, C.; Collet, J.F.; Van Schaftingen, E.; De Ranter, C.
High-resolution structure of human phosphoserine phosphatase in open conformation
Acta Crystallogr. Sect. D
59
971-977
2003
Homo sapiens
Manually annotated by BRENDA team
Nishiyama, T.; Sakemi, H.; Sumi, H.; Tokunaga, S.; Doi, K.; Ogata, S.
A chromosomal locus encoding a phosphoserine phosphatase- and a truncated MinD-like protein affects differentiation in Streptomyces azureus ATCC14921
FEMS Microbiol. Lett.
190
133-139
2000
Streptomyces azureus, Streptomyces azureus ATCC 14921
Manually annotated by BRENDA team
Kim, H.Y.; Heo, Y.S.; Kim, J.H.; Park, M.H.; Moon, J.; Kim, E.; Kwon, D.; Yoon, J.; Shin, D.; Jeong, E.J.; Park, S.Y.; Lee, T.G.; Jeon, Y.H.; Ro, S.; Cho, J.M.; Hwang, K.Y.
Molecular basis for the local conformational rearrangement of human phosphoserine phosphatase
J. Biol. Chem.
277
46651-46658
2002
Homo sapiens
Manually annotated by BRENDA team
Singh, S.K.; Yang, K.; Karthikeyan, S.; Huynh, T.; Zhang, X.; Phillips, M.A.; Zhang, H.
The thrH gene product of Pseudomonas aeruginosa is a dual activity enzyme with a novel phosphoserine:homoserine phosphotransferase activity
J. Biol. Chem.
279
13166-13173
2004
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Wang, W.; Cho, H.S.; Kim, R.; Jancarik, J.; Yokota, H.; Nguyen, H.H.; Grigoriev, I.V.; Wemmer, D.E.; Kim, S.H.
Structural characterization of the reaction pathway in phosphoserine phosphatase: crystallographic "snapshots" of intermediate states
J. Mol. Biol.
319
421-431
2002
Methanocaldococcus jannaschii (Q58989), Methanocaldococcus jannaschii
Manually annotated by BRENDA team
Heese, K.; Nagai, Y.; Sawada, T.
Induction of rat L-phosphoserine phosphatase by amyloid-beta (1-42) is inhibited by interleukin-11
Neurosci. Lett.
288
37-40
2000
Rattus norvegicus
Manually annotated by BRENDA team
Wang, W.; Kim, R.; Jancarik, J.; Yokota, H.; Kim, S.H.
Crystal structure of phosphoserine phosphatase from Methanococcus jannaschii, a hyperthermophile, at 1.8 A resolution
Structure
9
65-71
2001
Methanocaldococcus jannaschii
Manually annotated by BRENDA team
Peeraer, Y.; Rabijns, A.; Collet, J.F.; Van Schaftingen, E.; De Ranter, C.
How calcium inhibits the magnesium-dependent enzyme human phosphoserine phosphatase
Eur. J. Biochem.
271
3421-3427
2004
Homo sapiens
Manually annotated by BRENDA team
Proudfoot, M.
corresponding Author: Dr. Alexander Yakunin, C.H. Best Institute, 112 College St. Room 72, Toronto On M5G 1L6, Canada
Private Communication
10
1-1
2007
Saccharomyces cerevisiae (P42941)
-
Manually annotated by BRENDA team
Tribble, G.D.; Mao, S.; James, C.E.; Lamont, R.J.
A Porphyromonas gingivalis haloacid dehalogenase family phosphatase interacts with human phosphoproteins and is important for invasion
Proc. Natl. Acad. Sci. USA
103
11027-11032
2006
Porphyromonas gingivalis
Manually annotated by BRENDA team
Nakano, I.; Dougherty, J.D.; Kim, K.; Klement, I.; Geschwind, D.H.; Kornblum, H.I.
Phosphoserine phosphatase is expressed in the neural stem cell niche and regulates neural stem and progenitor cell proliferation
Stem Cells
25
1975-1984
2007
Mus musculus
Manually annotated by BRENDA team
Baxter, N.J.; Blackburn, G.M.; Marston, J.P.; Hounslow, A.M.; Cliff, M.J.; Bermel, W.; Williams, N.H.; Hollfelder, F.; Wemmer, D.E.; Waltho, J.P.
Anionic charge is prioritized over geometry in aluminum and magnesium fluoride transition state analogs of phosphoryl transfer enzymes
J. Am. Chem. Soc.
130
3952-3958
2008
Methanocaldococcus jannaschii (Q58989), Methanocaldococcus jannaschii
Manually annotated by BRENDA team
Antflick, J.E.; Baker, G.B.; Hampson, D.R.
The effects of a low protein diet on amino acids and enzymes in the serine synthesis pathway in mice
Amino Acids
39
145-153
2009
Mus musculus (Q99LS3), Mus musculus C57BL/6 (Q99LS3)
Manually annotated by BRENDA team
Antflick, J.E.; Vetiska, S.; Baizer, J.S.; Yao, Y.; Baker, G.B.; Hampson, D.R.
L-Serine-O-phosphate in the central nervous system
Brain Res.
1300
1-13
2009
Rattus norvegicus (Q5M819)
Manually annotated by BRENDA team
Pollari, S.; Kaekoenen, S.M.; Edgren, H.; Wolf, M.; Kohonen, P.; Sara, H.; Guise, T.; Nees, M.; Kallioniemi, O.
Enhanced serine production by bone metastatic breast cancer cells stimulates osteoclastogenesis
Breast Cancer Res. Treat.
125
421-430
2011
Homo sapiens
Manually annotated by BRENDA team
Bainbridge, B.; Verma, R.K.; Eastman, C.; Yehia, B.; Rivera, M.; Moffatt, C.; Bhattacharyya, I.; Lamont, R.J.; Kesavalu, L.
Role of Porphyromonas gingivalis phosphoserine phosphatase enzyme SerB in inflammation, immune response, and induction of alveolar bone resorption in rats
Infect. Immun.
78
4560-4569
2010
Porphyromonas gingivalis
Manually annotated by BRENDA team
Bachelor, M.A.; Lu, Y.; Owens, D.M.
L-3-Phosphoserine phosphatase (PSPH) regulates cutaneous squamous cell carcinoma proliferation independent of L-serine biosynthesis
J. Dermatol. Sci.
63
164-172
2011
Homo sapiens
Manually annotated by BRENDA team
Cho, H.; Wang, W.; Kim, R.; Yokota, H.; Damo, S.; Kim, S.H.; Wemmer, D.; Kustu, S.; Yan, D.
BeF(3)(-) acts as a phosphate analog in proteins phosphorylated on aspartate: structure of a BeF(3)(-) complex with phosphoserine phosphatase
Proc. Natl. Acad. Sci. USA
98
8525-8530
2001
Methanocaldococcus jannaschii (Q58989), Methanocaldococcus jannaschii, Methanocaldococcus jannaschii DSM 2661 (Q58989)
Manually annotated by BRENDA team
Jung, T.Y.; Kim, Y.S.; Oh, B.H.; Woo, E.
Identification of a novel ligand binding site in phosphoserine phosphatase from the hyperthermophilic archaeon Thermococcus onnurineus
Proteins
81
819-829
2013
Thermococcus onnurineus (B6YX36), Thermococcus onnurineus
Manually annotated by BRENDA team
Chiba, Y.; Horita, S.; Ohtsuka, J.; Arai, H.; Nagata, K.; Igarashi, Y.; Tanokura, M.; Ishii, M.
Crystallization and preliminary X-ray diffraction analysis of a novel type of phosphoserine phosphatase from Hydrogenobacter thermophilus TK-6
Acta Crystallogr. Sect. F
68
911-913
2012
Hydrogenobacter thermophilus (D3DFG8), Hydrogenobacter thermophilus TK-6 / IAM 12695 (D3DFG8)
Manually annotated by BRENDA team
Chiba, Y.; Oshima, K.; Arai, H.; Ishii, M.; Igarashi, Y.
Discovery and analysis of cofactor-dependent phosphoglycerate mutase homologs as novel phosphoserine phosphatases in Hydrogenobacter thermophilus
J. Biol. Chem.
287
11934-11941
2012
Hydrogenobacter thermophilus (D3DFG8), Hydrogenobacter thermophilus (D3DFP8), Hydrogenobacter thermophilus, Hydrogenobacter thermophilus DSM 6534 (D3DFG8), Hydrogenobacter thermophilus DSM 6534 (D3DFP8)
Manually annotated by BRENDA team
Chiba, Y.; Horita, S.; Ohtsuka, J.; Arai, H.; Nagata, K.; Igarashi, Y.; Tanokura, M.; Ishii, M.
Structural units important for activity of a novel-type phosphoserine phosphatase from Hydrogenobacter thermophilus TK-6 revealed by crystal structure analysis
J. Biol. Chem.
288
11448-11458
2013
Hydrogenobacter thermophilus (D3DFG8), Hydrogenobacter thermophilus, Hydrogenobacter thermophilus DSM 6534 (D3DFG8)
Manually annotated by BRENDA team
Arora, G.; Tiwari, P.; Mandal, R.S.; Gupta, A.; Sharma, D.; Saha, S.; Singh, R.
High throughput screen identifies small molecule inhibitors specific for Mycobacterium tuberculosis phosphoserine phosphatase
J. Biol. Chem.
289
25149-25165
2014
Mycobacterium tuberculosis (O53289), Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618 (O53289)
Manually annotated by BRENDA team
Cascales-Minana, B.; Munoz-Bertomeu, J.; Flores-Tornero, M.; Anoman, A.D.; Pertusa, J.; Alaiz, M.; Osorio, S.; Fernie, A.R.; Segura, J.; Ros, R.
The phosphorylated pathway of serine biosynthesis is essential both for male gametophyte and embryo development and for root growth in Arabidopsis
Plant Cell
25
2084-2101
2013
Arabidopsis thaliana
Manually annotated by BRENDA team
Sato, K.; Masuda, T.; Hu, Q.; Tobo, T.; Kidogami, S.; Ogawa, Y.; Saito, T.; Nambara, S.; Komatsu, H.; Hirata, H.; Sakimura, S.; Uchi, R.; Hayashi, N.; Iguchi, T.; Eguchi, H.; Ito, S.; Nakagawa, T.; Mimori, K.
Phosphoserine phosphatase is a novel prognostic biomarker on chromosome 7 in colorectal cancer
Anticancer Res.
37
2365-2371
2017
Homo sapiens (P78330)
Manually annotated by BRENDA team
Li, X.; Xun, Z.; Yang, Y.
Inhibition of phosphoserine phosphatase enhances the anticancer efficacy of 5-fluorouracil in colorectal cancer
Biochem. Biophys. Res. Commun.
477
633-639
2016
Homo sapiens (P78330), Homo sapiens
Manually annotated by BRENDA team
Grant, G.A.
Regulatory mechanism of Mycobacterium tuberculosis phosphoserine phosphatase SerB2
Biochemistry
56
6481-6490
2017
Mycobacterium tuberculosis (O53289), Mycobacterium tuberculosis
Manually annotated by BRENDA team
Kim, K.T.; Chiba, Y.; Arai, H.; Ishii, M.
Discovery of an intermolecular disulfide bond required for the thermostability of a heterodimeric protein from the thermophile Hydrogenobacter thermophilus
Biosci. Biotechnol. Biochem.
80
232-240
2016
Hydrogenobacter thermophilus, Hydrogenobacter thermophilus DSM 6534
Manually annotated by BRENDA team
Chiba, Y.; Yoshida, A.; Shimamura, S.; Kameya, M.; Tomita, T.; Nishiyama, M.; Takai, K.
Discovery and analysis of a novel type of the serine biosynthetic enzyme phosphoserine phosphatase in Thermus thermophilus
FEBS J.
286
726-736
2018
Thermus thermophilus
Manually annotated by BRENDA team
Samuilov, S.; Rademacher, N.; Brilhaus, D.; Flachbart, S.; Arab, L.; Kopriva, S.; Weber, A.P.M.; Mettler-Altmann, T.; Rennenberg, H.
Knock-down of the phosphoserine phosphatase gene effects rather N- than S-metabolism in Arabidopsis thaliana
Front. Plant Sci.
9
1830
2018
Arabidopsis thaliana
Manually annotated by BRENDA team
Janczarek, M.; Vinardell, J.M.; Lipa, P.; Karas, M.
Hanks-type Serine/threonine protein kinases and phosphatases in bacteria roles in signaling and adaptation to various environments
Int. J. Mol. Sci.
19
2872-2901
2018
Bacillus subtilis (O07014), Bacillus subtilis (P17906), Bacillus subtilis (P40399), Bacillus subtilis 168 (O07014), Bacillus subtilis 168 (P17906), Bacillus subtilis 168 (P40399)
Manually annotated by BRENDA team
Kim, K.; Chiba, Y.; Kobayashi, A.; Arai, H.; Ishii, M.
Phosphoserine phosphatase is required for serine and one-carbon unit synthesis in Hydrogenobacter thermophilus
J. Bacteriol.
199
e00409-17
2017
Hydrogenobacter thermophilus, Hydrogenobacter thermophilus TK-6
Manually annotated by BRENDA team
Krachtus, D.; Smith, J.C.; Imhof, P.
Quantum mechanical/molecular mechanical analysis of the catalytic mechanism of phosphoserine phosphatase
Molecules
23
3342
2018
Methanocaldococcus jannaschii (Q58989), Methanocaldococcus jannaschii ATCC 43067 (Q58989)
Manually annotated by BRENDA team
Ozeki, Y.; Sekine, M.; Fujii, K.; Watanabe, T.; Okayasu, H.; Takano, Y.; Shinozaki, T.; Aoki, A.; Akiyama, K.; Homma, H.; Shimoda, K.
Phosphoserine phosphatase activity is elevated and correlates negatively with plasma D-serine concentration in patients with schizophrenia
Psychiatry Res.
237
344-350
2016
Homo sapiens (P78330), Homo sapiens
Manually annotated by BRENDA team