3.1.3.23: sugar-phosphatase
This is an abbreviated version!
For detailed information about sugar-phosphatase, go to the full flat file.
Word Map on EC 3.1.3.23
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3.1.3.23
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phosphatases
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phosphosugars
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meningitidis
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d-ribose-5-phosphate
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c1-type
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methylerythritol
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broad-range
- 3.1.3.23
- phosphatases
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phosphosugars
- meningitidis
- d-ribose-5-phosphate
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c1-type
- methylerythritol
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broad-range
Reaction
Synonyms
AraL, ATM98_05090, HAD1, haloacid dehalogenase-like sugar phosphatase, More, Name, PF3D7 1033400, PFLU2693, phosphatase, sugar, phosphosugar phosphatase, Sgpp, SPP, sugar phosphatase, sugar phosphate phosphohydrolase
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General Information
General Information on EC 3.1.3.23 - sugar-phosphatase
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malfunction
loss of HAD1 is required for fosmidomycin resistance. Parasites lacking HAD1 have increased methylerythritol phosphate pathway metabolites, particularly the deoxyxylulose 5-phosphate reductoisomerase substrate deoxyxylulose 5-phosphate
metabolism
physiological function
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context of araL within the arabinose metabolic operon araABDLMNPQ-abfA, as involved in the transport of L-arabinose oligomers. the ability of AraL to catabolize several secondary metabolites, related to detoxification of accidental accumulation of phosphorylated metabolites, requires regulation at the genetic level. Production of AraL is regulated by a structure in the translation initiation region of the mRNA, which most probably blocks access to the ribosome-binding site, preventing protein synthesis, existence of a genetic regulatory mechanism controlling the production of AraL, overview
metabolism
HAD1 controls substrate availability to the methylerythritol phosphate pathway
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putative physiological role of the enzyme AraL in the detoxification of accidental accumulation of phosphorylated metabolites
physiological function
deletion of the Spp gene does not affect growth of the wild-type strain on fructose, but the gene cannot be deleted in the alginate-producing strain. Sugar phosphate accumulation in Spp mutant strains causes diminished growth in some of the strains, which is partially relieved by Spp overexpression. Overexpression of Spp in fructose-grown alginate-producing strains negatively affects both growth and alginate production
physiological function
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the accumulation of fructose 1-phosphate, as a result of growth on fructose, induces SppA expression, and it significantly alters biofilm maturation through increased cell lysis and enhanced extracellular DNA release. Constitutive expression of SppA greatly alleviates fructose-induced stress in a mutant lacking 1-phosphofructokinase, enhances resistance to xylitol, and reverses the effects of fructose on biofilm formation
physiological function
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deletion of the Spp gene does not affect growth of the wild-type strain on fructose, but the gene cannot be deleted in the alginate-producing strain. Sugar phosphate accumulation in Spp mutant strains causes diminished growth in some of the strains, which is partially relieved by Spp overexpression. Overexpression of Spp in fructose-grown alginate-producing strains negatively affects both growth and alginate production
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