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3.1.26.5: ribonuclease P

This is an abbreviated version!
For detailed information about ribonuclease P, go to the full flat file.

Word Map on EC 3.1.26.5

Reaction

endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor =

Synonyms

Aq_880, aRpp29, aRpp29 protein, AtPop1p, AtPRORP1, AtPRORP2, AtPRORP3, C5 protein, CrPRORP, hPOP1, hPOP4, hPOP7, M1 RNA, M1GS, M1GS RNA, mitochondrial RNase P protein 1, MRPP1, MRPP2, MRPP3, nuclear ribonclease P ribonucleoprotein, nuclease, ribo-, P, Pfu Pop5, PhoPRNA, POP1, Pop1p, Pop5, Pop6, Pop7, PRORP, PRORP1, PRORP2, PRORP3, Protein C5, protein-only ribonuclease P, protein-only RNase P, protein-only RNase P enzyme, proteinaceous RNase P, ribonuclease MRP, ribonuclease P, ribonuclease P ribozyme, ribosomal RNA processing ribonucleoprotein, Ribunuclease P, RNA processing protein POP1, RNA processing protein POP5, RNA processing protein POP6, RNA processing protein POP7, RNA processing protein POP8, RNase MRP, RNase P, RNase P holoenzyme, RNase P protein, RNase P ribozyme, RNase P RNA, RNase P/MRP, RNase P/MRP protein, RNaseP protein, RNaseP protein p20, RNaseP protein p30, RNaseP protein p38, RNaseP protein p40, RNases P, RNP, Rpm2p, RPP, RPP14, Rpp20, Rpp21, Rpp25, Rpp29, Rpp30, Rpp38, RPP40, RPR, RPR1, transfer RNA 5' maturation enzyme, transfer RNA processing enzyme, tRNA processing enzyme, tRNA-processing endonuclease, tRNA-processing enzyme

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.26 Endoribonucleases producing 5'-phosphomonoesters
                3.1.26.5 ribonuclease P

Activating Compound

Activating Compound on EC 3.1.26.5 - ribonuclease P

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-methyl-2,4-pentanediol
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enhances cleavage reaction of the M1 RNA subunit alone
erythromycin
-
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PhoPop5 protein
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PhoPop5 is an archaeal homolog of human RNase P protein hPop5 involved in the activation of RNase P RNA in the hyperthermophilic archaeon Pyrococcus horikoshii. Extra-structural elements in the RNA recognition motif in PhoPop5 play a crucial role in the activation, that is, the C-terminal extension in the dimerized PhoPop5 protein through the loop between alpha1 and alpha2 is essential for the activation of the enzyme by promoting RNA annealing and RNA strand displacement
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Polyethylene glycol
-
enhances cleavage reaction of the M1 RNA subunit alone
protein PhoPop5
the enzyme is enzymatically active only when bound to proteins PhoPop5, PhoRpp38, PhoRpp21, PhoRpp29, and PhoRpp30
-
protein PhoRpp21
the enzyme is enzymatically active only when bound to proteins PhoPop5, PhoRpp38, PhoRpp21, PhoRpp29, and PhoRpp30
-
protein PhoRpp29
the enzyme is enzymatically active only when bound to proteins PhoPop5, PhoRpp38, PhoRpp21, PhoRpp29, and PhoRpp30
-
protein PhoRpp30
the enzyme is enzymatically active only when bound to proteins PhoPop5, PhoRpp38, PhoRpp21, PhoRpp29, and PhoRpp30
-
protein PhoRpp38
the enzyme is enzymatically active only when bound to proteins PhoPop5, PhoRpp38, PhoRpp21, PhoRpp29, and PhoRpp30
-
roxithromycin
-
-
spermidine
spermine
spiramycin
-
most potent activator
tylosin
-
-
additional information
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