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3.1.25.1: deoxyribonuclease (pyrimidine dimer)

This is an abbreviated version!
For detailed information about deoxyribonuclease (pyrimidine dimer), go to the full flat file.

Word Map on EC 3.1.25.1

Reaction

endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate =

Synonyms

ApeI, bacteriophage T4 endodeoxyribonuclease V, bacteriophage T4 endonuclease V, correndonuclease I, correndonuclease II, endodeoxyribonuclease (pyrimidine dimer), endonuclease II, endonuclease III, endonuclease V, Escherichia coli UV endonuclease, excision endonuclease UvrABC, excision nuclease UvrABC, More, nuclease V, bacteriophage T4 endodeoxyribonuclease V, nuclease, Escherichia coli UV-endodeoxyribonuclease, Py-Py-correndonuclease, ribosomal protein S3, rpS3, T4 Endo V, T4 endonuclease V, T4N5, type I AP endonuclease, UvrA, UvrABC nuclease, UvrB, UvrC

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.25 Site-specific endodeoxyribonucleases that are specific for altered bases
                3.1.25.1 deoxyribonuclease (pyrimidine dimer)

Reference

Reference on EC 3.1.25.1 - deoxyribonuclease (pyrimidine dimer)

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Nakabeppu, Y.; Yamashita, K.; Sekiguchi, M.
Purification and characterization of normal and mutant forms of T4 endonuclease V
J. Biol. Chem.
257
2556-2562
1982
Tequatrovirus T4
Manually annotated by BRENDA team
Nakatsu, Y.; Nakabeppu, Y.; Sekiguchi, M.
Action of T4 endonuclease V on polydeoxyribonucleotides with apyrimidinic or apurinic sites
J. Biochem.
91
2057-2065
1982
Tequatrovirus T4
Manually annotated by BRENDA team
Minton, K.; Durphy, M.; Taylor, R.; Friedberg, E.C.
The ultraviolet endonuclease of bacteriophage T4. Further characterization
J. Biol. Chem.
250
2823-2829
1975
Tequatrovirus T4
Manually annotated by BRENDA team
Recinos , A.; Lloyd, R.S.
Site-directed mutagenesis of the T4 endonuclease V gene: role of lysine-130
Biochemistry
27
1832-1838
1988
Tequatrovirus T4
Manually annotated by BRENDA team
Stump, D.G.; Lloyd, R.S.
Site-directed mutagenesis of the T4 endonuclease V gene: role of tyrosine-129 and -131 in pyrimidine dimer-specific binding
Biochemistry
27
1839-1843
1988
Tequatrovirus T4
Manually annotated by BRENDA team
Morikawa, K.; Tsujimoto, M.; Ikehara, M.
Preliminary crystallographic study of pyrimidine dimer-specific excision-repair enzyme from bacteriophage T4
J. Mol. Biol.
202
683-684
1988
Tequatrovirus T4
Manually annotated by BRENDA team
Dowd, D.R.; Lloyd, R.S.
Site-directed mutagenesis of the T4 endonuclease V gene: the role of arginine-3 in the target search
Biochemistry
28
8699-8705
1989
Tequatrovirus T4
Manually annotated by BRENDA team
Gruskin, E.A.; Lloyd, R.S.
Molecular analysis of plasmid DNA repair within ultraviolet-irradiated Escherichia coli. I. T4 endonuclease V-initiated excision repair
J. Biol. Chem.
263
12728-12737
1988
Tequatrovirus T4
Manually annotated by BRENDA team
Inaoka, T.; Ishida, M.; Ohtsuka, E.
Affinity of single- or double-stranded oligodeoxyribonucleotides containing a thymine photodimer for T4 endonuclease V
J. Biol. Chem.
264
2609-2614
1989
Tequatrovirus T4
Manually annotated by BRENDA team
Ishida, M.; Kanamori, Y.; Hori, N.; Inaoka, T.; Ohtsuka, E.
In vitro and in vivo activities of T4 endonuclease V mutants altered in the C-terminal aromatic region
Biochemistry
29
3817-3821
1990
Tequatrovirus T4
Manually annotated by BRENDA team
Makino, F.; Tanooka, H.; Sekiguchi, M.
Action of T4 endonuclease V on DNA containing various photoproducts
J. Biochem.
82
1567-1573
1977
Tequatrovirus T4
Manually annotated by BRENDA team
Sato, K.; Sekiguchi, M.
Studies on temperature-dependent ultraviolet light-sensitive mutants of bacteriophage T4: the structural gene for T4 endonuclease V
J. Mol. Biol.
102
15-26
1976
Tequatrovirus T4
Manually annotated by BRENDA team
Nakabeppu, Y.; Sekiguchi, M.
Physical association of pyrimidine dimer DNA glycosylase and apurinic/apyrimidinic DNA endonuclease essential for repair of ultraviolet-damaged DNA
Proc. Natl. Acad. Sci. USA
78
2742-2746
1981
Tequatrovirus T4
Manually annotated by BRENDA team
Riazuddin, S.; Grossman, L.
Micrococcus luteus correndonucleases. I. resolution and purification of two endonucleases specific for DNA containing pyrimidine dimers
J. Biol. Chem.
252
6280-6286
1977
Micrococcus luteus
Manually annotated by BRENDA team
Riazuddin, S.; Grossman, L.
Micrococcus luteus correndonucleases. II. Mechanism of action of two endonucleases specific for DNA containing pyrimidine dimers
J. Biol. Chem.
252
6287-6293
1977
Micrococcus luteus
Manually annotated by BRENDA team
Riazuddin, S.; Grossman, L.
Micrococcus luteus correndonucleases. III. Evidence for involvement in repair in vivo of two endonucleases specific for DNA containing pyrimidine dimers
J. Biol. Chem.
252
6294-6298
1977
Micrococcus luteus
Manually annotated by BRENDA team
Braun, A.G.; Radman, M.; Grossman, L.
Enzymatic repair of DNA: Sites of hydrolysis by the Escherichia coli endonuclease specific for pyrimidine dimers (correndonuclease II)
Biochemistry
15
4116-4120
1976
Escherichia coli
Manually annotated by BRENDA team
Riazuddin, S.
Purification and properties of pyrimidine dimer specific endonucleases from Micrococcus luteus
Methods Enzymol.
65
185-191
1980
Micrococcus luteus
Manually annotated by BRENDA team
Friedberg, E.C.; Ganesan, A.K.; Seawell, P.C.
Purification and properties of a pyrimidine dimer-specific endonuclease from E. coli infected with bacteriophage T4
Methods Enzymol.
65
191-201
1980
Tequatrovirus T4
Manually annotated by BRENDA team
Valerie, K.
Replacing tryptophan-128 of T4 endonuclease V with a serine residue results in decreased enzymatic activity in vitro and in vivo
Nucleic Acids Res.
23
3764-3770
1995
Tequatrovirus T4
Manually annotated by BRENDA team
Latham, K.A.; Lloyd, R.S.
T4 endonuclease V, perspectives on catalysis
Ann. N. Y. Acad. Sci.
726
181-197
1994
Tequatrovirus T4
Manually annotated by BRENDA team
Kibitel, J.T.; Yee, V.; Yarosh, D.B.
Enhancment of ultraviolet-DNA repair in denV-gene transfectants and T4 endonuclease V-liposome recipients
Photochem. Photobiol.
54
753-760
1991
Tequatrovirus T4
Manually annotated by BRENDA team
Shiota, S.; Nakayama, H.
UV endonuclease of Micrococcus luteus, a cyclobutane pyrimidine dimer-DNA glycosylase/abasic lyase: Cloning and characterization of the gene
Proc. Natl. Acad. Sci. USA
94
593-598
1997
Micrococcus luteus
Manually annotated by BRENDA team
Piersen, C.E.; Prince, M.A.; Augustine, M.L.; Dodson, M.L.; Lloyd, R.S.
Purification and cloning of Micrococcus luteus ultraviolet endonuclease, an N-glycosylase/abasic lyase that proceeds via an imino enzyme-DNA intermediate
J. Biol. Chem.
270
23475-23484
1995
Micrococcus luteus
Manually annotated by BRENDA team
Ahn, H.C.; Ohkubo, T.; Iwai, S.; Morikawa, K.; Lee, B.J.
Interaction of T4 endonuclease V with DNA: importance of the flexible loop regions in protein-DNA interaction
J. Biol. Chem.
278
30985-30992
2003
Tequatrovirus T4 (P04418)
Manually annotated by BRENDA team
Morikawa, K.; Shirakawa, M.
Three-dimensional structural views of damaged-DNA recognition: T4 endonuclease V, E. coli Vsr protein, and human nucleotide excision repair factor XPA
Mutat. Res.
460
257-275
2000
Tequatrovirus T4
Manually annotated by BRENDA team
Yarosh, D.B.
Enhanced DNA repair of cyclobutane pyrimidine dimers changes the biological response to UV-B radiation
Mutat. Res.
509
221-226
2002
Tequatrovirus T4
Manually annotated by BRENDA team
Takasawa, K.; Masutani, C.; Hanaoka, F.; Iwai, S.
Chemical synthesis and translesion replication of a cis-syn cyclobutane thymine-uracil dimer
Nucleic Acids Res.
32
1738-1745
2004
Tequatrovirus T4
Manually annotated by BRENDA team
Kim Sang, H.; Lee Jae, Y.; Kim, J.
Characterization of a wide range base-damage-endonuclease activity of mammalian rpS3
Biochem. Biophys. Res. Commun.
328
962-967
2005
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Minko, I.G.; Kurtz, A.J.; Croteau, D.L.; Van Houten, B.; Harris, T.M.; Lloyd, R.S.
Initiation of repair of DNA-polypeptide cross-links by the UvrABC nuclease
Biochemistry
44
3000-3009
2005
[Bacillus] caldotenax, Thermotoga maritima
Manually annotated by BRENDA team
Feng, H.; Klutz, A.; Cao, W.
Active site plasticity of endonuclease V from Salmonella typhimurium
Biochemistry
44
675-683
2005
Salmonella enterica subsp. enterica serovar Typhimurium, Salmonella enterica subsp. enterica serovar Typhimurium 14028
Manually annotated by BRENDA team
Yang, Z.; Colis, L.C.; Basu, A.K.; Zou, Y.
Recognition and incision of gamma-radiation-induced cross-linked guanine-thymine tandem lesion G[8,5-Me]T by UvrABC nuclease
Chem. Res. Toxicol.
18
1339-1346
2005
Escherichia coli
Manually annotated by BRENDA team
Kuchel, J.M.; Barnetson, R.S.; Halliday, G.M.
Cyclobutane pyrimidine dimer formation is a molecular trigger for solar-simulated ultraviolet radiation-induced suppression of memory immunity in humans
Photochem. Photobiol. Sci.
4
577-582
2005
Tequatrovirus T4
Manually annotated by BRENDA team
Jiang, Y.; Rabbi, M.; Kim, M.; Ke, C.; Lee, W.; Clark, R.L.; Mieczkowski, P.A.; Marszalek, P.E.
UVA generates pyrimidine dimers in DNA directly
Biophys. J.
96
1151-1158
2009
Escherichia coli
Manually annotated by BRENDA team
Hacker, E.; Muller, H.K.; Hayward, N.; Fahey, P.; Walker, G.
Enhancement of DNA repair using topical T4 endonuclease V does not inhibit melanoma formation in Cdk4(R24C/R24C)/Tyr-Nras(Q61K) mice following neonatal UVR
Pigment Cell Melanoma Res.
23
121-128
2010
Mus musculus
Manually annotated by BRENDA team