3.1.21.6: CC-preferring endodeoxyribonuclease
This is an abbreviated version!
For detailed information about CC-preferring endodeoxyribonuclease, go to the full flat file.
Word Map on EC 3.1.21.6
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3.1.21.6
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bacteriophage
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nick
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apurinic
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exonuclease
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endonucleases
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phosphodiester
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depurinated
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endonucleolytic
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cytosine-containing
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incise
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superhelical
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coliphage
- 3.1.21.6
- bacteriophage
- nick
-
apurinic
-
exonuclease
- endonucleases
-
phosphodiester
-
depurinated
-
endonucleolytic
-
cytosine-containing
-
incise
-
superhelical
-
coliphage
Reaction
Endonucleolytic cleavage to give 5'-phosphooligonucleotide end-products, with a preference for cleavage within the sequence CC =
Synonyms
Deoxyriboendonuclease, DNA-adenine-transferase, EC 3.1.4.30, endodeoxyribonuclease, endonuclease II, endonuclease NX, endonuclease T, Escherichia coli endonuclease II, Nuclease, endodeoxyribo-, R1Bm EN, R1Bm endonuclease, Redoxyendonuclease, Streptomyces glaucescens exocytoplasmic dodeoxyribonuclease, VirD1/D2 endonuclease
ECTree
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Engineering
Engineering on EC 3.1.21.6 - CC-preferring endodeoxyribonuclease
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D19A
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relative activity of bottom-strand cleavage is less than half that of top-strand cleavage, whereas activity of top-strand cleavage is more than 80% that of the wild-type
E147A
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does not exhibit a significant reduction in nicking activity, compared with that of the wild-type
E18A
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relative activity of bottom-strand cleavage is less than half that of top-strand cleavage, whereas activity of top-strand cleavage is more than 80% that of the wild-type
H140A
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shows less than 20% of the wild-type activity for the cleavage of both strands, amounts of cleavage products are less than 1% of the total substrates
H209A
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exhibits no detectable cleavage activity on the top or bottom strand of the oligonucleotide substrate
H54A
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relative activity of bottom-strand cleavage is less than half that of top-strand cleavage, whereas activity of top-strand cleavage is more than 80% that of the wild-type
H78A
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shows less than 20% of the wild-type activity for the cleavage of both strands, amounts of cleavage products are less than 1% of the total substrates
N180A
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altered cleavage patterns, shows less than 20% of the wild-type activity for the cleavage of both strands, amounts of cleavage products are less than 1% of the total substrates
Q97A
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shows less than 20% of the wild-type activity for the cleavage of both strands, amounts of cleavage products are less than 1% of the total substrates
R139A
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shows less than 20% of the wild-type activity for the cleavage of both strands, amounts of cleavage products are less than 1% of the total substrates
R144A
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shows less than 20% of the wild-type activity for the cleavage of both strands, amounts of cleavage products are less than 1% of the total substrates
S206A
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relative activity of bottom-strand cleavage is less than half that of top-strand cleavage, whereas activity of top-strand cleavage is more than 80% that of the wild-type
S43A
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does not exhibit a significant reduction in nicking activity, compared with that of the wild-type
S99A
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does not exhibit a significant reduction in nicking activity, compared with that of the wild-type
T178A
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shows less than 20% of the wild-type activity for the cleavage of both strands, amounts of cleavage products are less than 1% of the total substrates
Y42A
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shows less than 20% of the wild-type activity for the cleavage of both strands, amounts of cleavage products are less than 1% of the total substrates
Y98A
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altered cleavage patterns, shows less than 20% of the wild-type activity for the cleavage of both strands, amounts of cleavage products are less than 1% of the total substrates