3.1.21.2: deoxyribonuclease IV

This is an abbreviated version!
For detailed information about deoxyribonuclease IV, go to the full flat file.

Word Map on EC 3.1.21.2

Reaction

Endonucleolytic cleavage of ssDNA at apurinic/apyrimidinic sites to 5'-phosphooligonucleotide end-products =

Synonyms

More, DNA-adenine-transferase, endonuclease II, EC 3.1.4.30, endodeoxyribonuclease IV, E. coli endonuclease IV, T4 endonuclease IV, nuclease, endodeoxyribo-oder redoxyendonuclease, deoxriboendonuclease, Nfo, exonuclease III, EndoII, apurinic/apyrimidinic endonuclease, endonuclease IV, Endo IV, TthNfo, coliphage T4 endonuclease II, type IV methyl-dependent restriction endonuclease, ScoA3McrA, Sco4631, EndoIV, End, Rv0670, MtbXthA, MtbNfo, MtbEndo IV

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.21 Endodeoxyribonucleases producing 5'-phosphomonoesters
                3.1.21.2 deoxyribonuclease IV

Reference

Reference on EC 3.1.21.2 - deoxyribonuclease IV

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sadowski, P.D.; Hurwitz, J.
Enzymatic breakage of deoxyribonucleic acid. II. Purification and properties of endonuclease IV from T4 phage-infected Escherichia coli
J. Biol. Chem.
244
6192-6198
1969
Escherichia coli, Escherichia coli B / ATCC 11303
Manually annotated by BRENDA team
Friedberg, E.C.; Hadi, S.M.; Goldthwait, D.A.
Endonuclease II of Escherichia coli. II. Enzyme properties and studies on the degradation of alkylated and native deoxyribonucleic acid
J. Biol. Chem.
244
5879-5889
1969
Escherichia coli
Manually annotated by BRENDA team
Carlson, K.; Lagerback, P.; Nystrom, A.C.
Bacteriophage T4 endonuclease II: concerted single-strand nicks yield double-strand cleavage
Mol. Microbiol.
52
1403-1411
2004
Escherichia virus T4
Manually annotated by BRENDA team
Souza, L.L.; Eduardo, I.R.; Padula, M.; Leitao, A.C.
Endonuclease IV and exonuclease III are involved in the repair and mutagenesis of DNA lesions induced by UVB in Escherichia coli
Mutagenesis
21
125-130
2006
Escherichia coli (P0A6C1), Escherichia coli
Manually annotated by BRENDA team
Hirano, N.; Ohshima, H.; Takahashi, H.
Biochemical analysis of the substrate specificity and sequence preference of endonuclease IV from bacteriophage T4, a dC-specific endonuclease implicated in restriction of dC-substituted T4 DNA synthesis
Nucleic Acids Res.
34
4743-4751
2006
Escherichia virus T4
Manually annotated by BRENDA team
Ohshima, H.; Hirano, N.; Takahashi, H.
A hexanucleotide sequence (dC1-dC6 tract) restricts the dC-specific cleavage of single-stranded DNA by endonuclease IV of bacteriophage T4
Nucleic Acids Res.
35
6681-6689
2007
Escherichia virus T4
Manually annotated by BRENDA team
Hirano, N.; Ohshima, H.; Sakashita, H.; Takahashi, H.
The Ser176 of T4 endonuclease IV is crucial for the restricted and polarized dC-specific cleavage of single-stranded DNA implicated in restriction of dC-containing DNA in host Escherichia coli
Nucleic Acids Res.
35
6692-6700
2007
Escherichia virus T4
Manually annotated by BRENDA team
Ivanov, I.; Tainer, J.A.; McCammon, J.A.
Unraveling the three-metal-ion catalytic mechanism of the DNA repair enzyme endonuclease IV
Proc. Natl. Acad. Sci. USA
104
1465-1470
2007
Escherichia coli (P0A6C1)
Manually annotated by BRENDA team
Back, J.H.; Chung, J.H.; Park, J.H.; Han, Y.S.
A versatile endonuclease IV from Thermus thermophilus has uracil-excising and 3-5 exonuclease activity
Biochem. Biophys. Res. Commun.
346
889-895
2006
Thermus thermophilus (Q72KH8), Thermus thermophilus
Manually annotated by BRENDA team
Hughes, R.C.; Tomanicek, S.J.; Ng, J.D.; Coates, L.
Purification, crystallization and preliminary crystallographic analysis of a thermostable endonuclease IV from Thermotoga maritima
Acta Crystallogr. Sect. F
65
1317-1319
2009
Thermotoga maritima (Q9WYJ7), Thermotoga maritima, Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589 (Q9WYJ7)
Manually annotated by BRENDA team
Motta, E.S.; Souza-Santos, P.T.; Cassiano, T.R.; Dantas, F.J.; Caldeira-de-Araujo, A.; De Mattos, J.C.
Endonuclease IV is the main base excision repair enzyme involved in DNA damage induced by UVA radiation and stannous chloride
J. Biomed. Biotechnol.
2010
376218
2010
Escherichia coli, Escherichia coli AB1157
Manually annotated by BRENDA team
Andersson, C.E.; Lagerbaeck, P.; Carlson, K.
Structure of bacteriophage T4 endonuclease II mutant E118A, a tetrameric GIY-YIG enzyme
J. Mol. Biol.
397
1003-1016
2010
Escherichia virus T4
Manually annotated by BRENDA team
Golan, G.; Ishchenko, A.; Khassenov, B.; Shoham, G.; Saparbaev, M.
Coupling of the nucleotide incision and 3'-5' exonuclease activities in Escherichia coli endonuclease IV: Structural and genetic evidences
Mutat. Res.
685
70-79
2010
Escherichia coli, Escherichia coli AB1157
Manually annotated by BRENDA team
Liu, G.; Ou, H.; Wang, T.; Li, L.; Tan, H.; Zhou, X.; Rajakumar, K.; Deng, Z.; He, X.
Cleavage of phosphorothioated DNA and methylated DNA by the type IV restriction endonuclease ScoMcrA
PLoS Genet.
6
1-13
2010
Streptomyces coelicolor, Streptomyces coelicolor A(3)2
Manually annotated by BRENDA team
Xie, J.J.; Liu, X.P.; Han, Z.; Yuan, H.; Wang, Y.; Hou, J.L.; Liu, J.H.
Chlamydophila pneumoniae endonuclease IV prefers to remove mismatched 3 ribonucleotides: implication in proofreading mismatched 3-terminal nucleotides in short-patch repair synthesis
DNA Repair
12
140-147
2013
Chlamydia pneumoniae
Manually annotated by BRENDA team
Tsutakawa, S.E.; Shin, D.S.; Mol, C.D.; Izumi, T.; Arvai, A.S.; Mantha, A.K.; Szczesny, B.; Ivanov, I.N.; Hosfield, D.J.; Maiti, B.; Pique, M.E.; Frankel, K.A.; Hitomi, K.; Cunningham, R.P.; Mitra, S.; Tainer, J.A.
Conserved structural chemistry for incision activity in structurally non-homologous apurinic/apyrimidinic endonuclease APE1 and endonuclease IV DNA repair enzymes
J. Biol. Chem.
288
8445-8455
2013
Thermotoga maritima (Q9WYJ7), Thermotoga maritima DSM 3109 (Q9WYJ7)
Manually annotated by BRENDA team
Puri, R.V.; Singh, N.; Gupta, R.K.; Tyagi, A.K.
Endonuclease IV Is the major apurinic/apyrimidinic endonuclease in Mycobacterium tuberculosis and is important for protection against oxidative damage
PLoS ONE
8
e71535
2013
Mycobacterium tuberculosis (P9WQ13), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WQ13)
Manually annotated by BRENDA team
Haas, B.; Sandigursky, M.; Tainer, J.; Franklin, W.; Cunningham, R.
Purification and characterization of Thermotoga maritima endonuclease IV, a thermostable apurinic/apyrimidinic endonuclease and 3-repair diesterase
J. Bacteriol.
181
2834-2839
1999
Thermotoga maritima (Q9WYJ7), Thermotoga maritima, Thermotoga maritima DSM 3109 (Q9WYJ7)
Manually annotated by BRENDA team
Kong, X.J.; Wu, S.; Cen, Y.; Chen, T.T.; Yu, R.Q.; Chu, X.
Endonuclease IV cleaves apurinic/apyrimidinic sites in single-stranded DNA and its application for biosensing
Analyst
141
4373-4380
2016
Homo sapiens
Manually annotated by BRENDA team
Zhang, W.; Xu, Y.; Yan, M.; Li, S.; Wang, H.; Yang, H.; Zhou, W.; Rao, Z.
Crystal structure of the apurinic/apyrimidinic endonuclease IV from Mycobacterium tuberculosis
Biochem. Biophys. Res. Commun.
498
111-118
2018
Mycobacterium tuberculosis (P9WQ13), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WQ13)
Manually annotated by BRENDA team
Abeldenov, S.; Talhaoui, I.; Zharkov, D.O.; Ishchenko, A.A.; Ramanculov, E.; Saparbaev, M.; Khassenov, B.
Characterization of DNA substrate specificities of apurinic/apyrimidinic endonucleases from Mycobacterium tuberculosis
DNA Repair
33
1-16
2015
Mycobacterium tuberculosis (P96273), Mycobacterium tuberculosis (P9WQ13), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P96273), Mycobacterium tuberculosis H37Rv (P9WQ13)
Manually annotated by BRENDA team
Wang, W.W.; Zhou, H.; Xie, J.J.; Yi, G.S.; He, J.H.; Wang, F.P.; Xiao, X.; Liu, X.P.
Thermococcus eurythermalis endonuclease IV can cleave various apurinic/apyrimidinic site analogues in ssDNA and dsDNA
Int. J. Mol. Sci.
20
69
2018
Thermococcus eurythermalis
Manually annotated by BRENDA team