3.1.2.5: hydroxymethylglutaryl-CoA hydrolase

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For detailed information about hydroxymethylglutaryl-CoA hydrolase, go to the full flat file.

Reaction

Synonyms

3-hydroxy-3-methylglutaryl-CoA hydrolase, beta-hydroxy-beta-methylglutaryl coenzyme A deacylase, beta-hydroxy-beta-methylglutaryl coenzyme A hydrolase, hydrolase, hydroxymethylglutaryl coenzyme A, hydroxymethylglutaryl coenzyme A deacylase

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.2 Thioester hydrolases

                3.1.2.5 hydroxymethylglutaryl-CoA hydrolase

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Results	in table
3	AA Sequence
1	CAS Registry Number
2	KM Value [mM]
3	Localization
7	Natural Substrates/ Products (Substrates)
7	Organism
2	pH Optimum
2	pH Range
1	Reaction
1	Reaction Type
7	Reference
5	Source Tissue
1	Storage Stability
14	Substrates and Products (Substrate)
5	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
3	Temperature Stability [°C]

Temperature Stability

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Temperature Stability on EC 3.1.2.5 - hydroxymethylglutaryl-CoA hydrolase

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TEMPERATURE STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

20

Rattus norvegicus

-

without substrate, microsomal, 31% loss of activity after 15 min

81014

37

Rattus norvegicus

-

without substrate, cytoplasm, 25% loss of activity after 30 min, microsomal, 50% loss of activity after 5 min

81014

4

Rattus norvegicus

-

microsomal, 6 h stable

81014