3.1.2.5: hydroxymethylglutaryl-CoA hydrolase

This is an abbreviated version!
For detailed information about hydroxymethylglutaryl-CoA hydrolase, go to the full flat file.

Reaction

Synonyms

3-hydroxy-3-methylglutaryl-CoA hydrolase, beta-hydroxy-beta-methylglutaryl coenzyme A deacylase, beta-hydroxy-beta-methylglutaryl coenzyme A hydrolase, hydrolase, hydroxymethylglutaryl coenzyme A, hydroxymethylglutaryl coenzyme A deacylase

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.2 Thioester hydrolases

                3.1.2.5 hydroxymethylglutaryl-CoA hydrolase

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Results	in table
3	AA Sequence
1	CAS Registry Number
2	KM Value [mM]
3	Localization
7	Natural Substrates/ Products (Substrates)
7	Organism
2	pH Optimum
2	pH Range
1	Reaction
1	Reaction Type
7	Reference
5	Source Tissue
1	Storage Stability
14	Substrates and Products (Substrate)
5	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
3	Temperature Stability [°C]

Substrates Products

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Substrates Products on EC 3.1.2.5 - hydroxymethylglutaryl-CoA hydrolase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

(S)-3-hydroxy-3-methylglutaryl-CoA + H2O

?

6 entries

(S)-3-hydroxy-3-methylglutaryl-CoA + H2O

CoA + 3-hydroxy-3-methylglutarate

7 entries

(S)-3-hydroxy-3-methylglutaryl-CoA + H2O

?

Escherichia coli

-

-

81015

-

-

?

(S)-3-hydroxy-3-methylglutaryl-CoA + H2O

?

Gallus gallus

-

-

81015

-

-

?

(S)-3-hydroxy-3-methylglutaryl-CoA + H2O

?

Neurospora crassa

-

-

81015

-

-

?

(S)-3-hydroxy-3-methylglutaryl-CoA + H2O

?

Rattus norvegicus

-

-

81014, 81016

-

-

?

(S)-3-hydroxy-3-methylglutaryl-CoA + H2O

?

Sus scrofa

-

-

81015

-

-

?

(S)-3-hydroxy-3-methylglutaryl-CoA + H2O

?

Tetrahymena pyriformis

-

-

81015

-

-

?

(S)-3-hydroxy-3-methylglutaryl-CoA + H2O

CoA + 3-hydroxy-3-methylglutarate

Escherichia coli

-

-

81015

-

-

?

(S)-3-hydroxy-3-methylglutaryl-CoA + H2O

CoA + 3-hydroxy-3-methylglutarate

Gallus gallus

-

-

81015

-

-

?

(S)-3-hydroxy-3-methylglutaryl-CoA + H2O

CoA + 3-hydroxy-3-methylglutarate

Neurospora crassa

-

-

81015

-

-

?

(S)-3-hydroxy-3-methylglutaryl-CoA + H2O

CoA + 3-hydroxy-3-methylglutarate

Rattus norvegicus

-

-

81014

-

81014

?

(S)-3-hydroxy-3-methylglutaryl-CoA + H2O

CoA + 3-hydroxy-3-methylglutarate

Rattus norvegicus

-

-

81016

-

-

?

(S)-3-hydroxy-3-methylglutaryl-CoA + H2O

CoA + 3-hydroxy-3-methylglutarate

Sus scrofa

-

-

81015

-

-

?

(S)-3-hydroxy-3-methylglutaryl-CoA + H2O

CoA + 3-hydroxy-3-methylglutarate

Tetrahymena pyriformis

-

-

81015

-

-

?