3.1.2.4: 3-hydroxyisobutyryl-CoA hydrolase

This is an abbreviated version!
For detailed information about 3-hydroxyisobutyryl-CoA hydrolase, go to the full flat file.

Reaction

Synonyms

3-hydroxy-isobutyryl CoA hydrolase, 3-hydroxyisobutyryl-CoA hydrolase, BCH, beta-hydroxyisobutyryl-CoA hydrolase, beta-hydroxyisobutyryl-coenzyme A hydrolase, CHY1, HIB CoA hydrolase, HIB-CoA hydrolase, HIBCH, HIBYL-CoA hydrolase, HICH, hydrolase, 3-hydroxyisobutyryl coenzyme A, More, NGR_b20860, Smb20752, VutE

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.2 Thioester hydrolases

                3.1.2.4 3-hydroxyisobutyryl-CoA hydrolase

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Results	in table
2394	AA Sequence
1	CAS Registry Number
5	Cloned(Commentary)
161	Disease/ Diagnostics
16	General Information
17	Inhibitors
8	Ki Value [mM]
5	KM Value [mM]
4	Localization
1	Metals/Ions
7	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
22	Organism
12	Pathway
17	PDB ID
6	pH Optimum
3	pH Range
4	Protein Variants
5	Purification (Commentary)
2	Reaction
5	Reaction Type
20	Reference
23	Source Tissue
6	Specific Activity [micromol/min/mg]
41	Substrates and Products (Substrate)
6	Subunits
28	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
5	Turnover Number [1/s]

pH Range

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pH Range on EC 3.1.2.4 - 3-hydroxyisobutyryl-CoA hydrolase

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pH RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

5 - 10.5

Rattus norvegicus

-

pH 5.0: about 40% of maximal activity, pH 10.5: about 80% of maximal activity, hydrolysis of 3-hydroxy-2-methylpropanoyl-CoA

94558

5 - 7

Rattus norvegicus

-

pH 5.0, about 30% of maximal activity, pH 7.0: 65% of maximal activity, hydrolysis of (S)-methylmalonyl-CoA

94558

5.1 - 10.3

Homo sapiens

-

at least

653127