3.1.2.4: 3-hydroxyisobutyryl-CoA hydrolase
This is an abbreviated version!
For detailed information about 3-hydroxyisobutyryl-CoA hydrolase, go to the full flat file.
Word Map on EC 3.1.2.4
Reaction
Synonyms
3-hydroxy-isobutyryl CoA hydrolase, 3-hydroxyisobutyryl-CoA hydrolase, BCH, beta-hydroxyisobutyryl-CoA hydrolase, beta-hydroxyisobutyryl-coenzyme A hydrolase, CHY1, HIB CoA hydrolase, HIB-CoA hydrolase, HIBCH, HIBYL-CoA hydrolase, HICH, hydrolase, 3-hydroxyisobutyryl coenzyme A, More, NGR_b20860, Smb20752, VutE
ECTree
3.1.2.4 3-hydroxyisobutyryl-CoA hydrolaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 3.1.2.4 - 3-hydroxyisobutyryl-CoA hydrolase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(S)-3-hydroxy-2-methylpropanoyl-CoA + H2O
CoA + (S)-3-hydroxy-2-methylpropanoate
-
-
-
?
3-hydroxy-2-methylbutyryl-CoA + H2O
CoA + 3-hydroxy-2-methylbutyrate
-
low activity
-
?
3-hydroxy-2-methylpropanoyl-CoA + H2O
3-hydroxy-2-methylpropanoate + CoA
-
substrate is an intermediate in the pathway of valine catabolism, which is unique in that it produces a radily diffusible monocarboxylic acid
-
?
3-hydroxy-3-phenylpropionyl-CoA + H2O
3-hydroxy-3-phenylpropionate + CoA
-
-
-
?
3-hydroxyisobutyryl-CoA + H2O
CoA + 3-hydroxyisobutyrate
-
formation of an anhydride reaction intermediate, Glu164 is involved
-
?
DL-3-hydroxybutyryl-CoA + H2O
CoA + DL-3-hydroxybutyrate
-
low activity
-
?
L-3-hydroxybutyryl-CoA + H2O
CoA + L-3-hydroxybutyrate
-
low activity
-
?
(S)-3-hydroxyisobutyryl-CoA + H2O
CoA + (S)-3-hydroxyisobutyrate
-
-
-
-
ir
(S)-3-hydroxyisobutyryl-CoA + H2O
CoA + (S)-3-hydroxyisobutyrate
-
-
-
ir
(S)-3-hydroxyisobutyryl-CoA + H2O
CoA + (S)-3-hydroxyisobutyrate
-
-
-
ir
(S)-3-hydroxyisobutyryl-CoA + H2O
CoA + (S)-3-hydroxyisobutyrate
-
-
-
-
ir
(S)-3-hydroxyisobutyryl-CoA + H2O
CoA + (S)-3-hydroxyisobutyrate
Sinorhizobium meliloti RmP798
-
-
-
-
ir
3-hydroxy-2-methylpropanoyl-CoA + H2O
?
the enzyme is responsible for the specific hydrolysis of 3-hydroxy-2-methylpropanoyl-CoA, a saline catabolite
-
-
?
3-hydroxy-2-methylpropanoyl-CoA + H2O
?
-
enzyme is involved in Val catabolism. The enzyme protects cells against toxic effects of methacrylyl-CoA, an intermediate in the Val pathway occuring upstream of 3-hydroxy-2-methylpropanoyl-CoA
-
-
?
3-hydroxy-2-methylpropanoyl-CoA + H2O
CoA + 3-hydroxy-2-methylpropanoate
-
(S)-3-hydroxyacids and their esters, such as (S)-3-hydroxybutyric acid, can be used as chiral building blocks for the chemical synthesis of optically active fine chemicals such as antibiotics, vitamins, perfumes, and pheromones
-
?
3-hydroxy-2-methylpropanoyl-CoA + H2O
CoA + 3-hydroxy-2-methylpropanoate
-
-
-
-
?
3-hydroxy-2-methylpropanoyl-CoA + H2O
CoA + 3-hydroxy-2-methylpropanoate
-
-
-
?
3-hydroxy-2-methylpropanoyl-CoA + H2O
CoA + 3-hydroxy-2-methylpropanoate
-
-
-
ir
3-hydroxy-2-methylpropanoyl-CoA + H2O
CoA + 3-hydroxy-2-methylpropanoate
-
-
-
?
3-hydroxy-2-methylpropanoyl-CoA + H2O
CoA + 3-hydroxy-2-methylpropanoate
-
key enzyme in valine metabolism regulating the toxic concentration of methacrylyl-coenzyme A, human liver disease decreases the enzyme activity in vivo
-
ir
3-hydroxy-2-methylpropanoyl-CoA + H2O
CoA + 3-hydroxy-2-methylpropanoate
-
-
-
-
?
3-hydroxy-2-methylpropanoyl-CoA + H2O
CoA + 3-hydroxy-2-methylpropanoate
-
-
-
-
?
3-hydroxy-2-methylpropanoyl-CoA + H2O
CoA + 3-hydroxy-2-methylpropanoate
-
-
-
-
?
3-hydroxy-2-methylpropanoyl-CoA + H2O
CoA + 3-hydroxy-2-methylpropanoate
-
-
-
?
3-hydroxypropanoyl-CoA + H2O
CoA + 3-hydroxypropanoate
hydrolysis of beta-hydroxypropionyl-CoA, an intermediate in a minor pathway of propionate metabolism
-
-
?
additional information
?
-
has no hydrolase activity with benzoyl-CoA
-
-
?
additional information
?
-
-
has no hydrolase activity with benzoyl-CoA
-
-
?
additional information
?
-
-
substrate specificity, overview, acetoacetyl-CoA, DL-methylmalonyl-CoA, isobutyryl-CoA, malonyl-CoA, acetyl-CoA, propionyl-CoA, and n-valeryl-CoA are poor substrates
-
?
additional information
?
-
mutations in the gene encoding 3-hydroxyisobutyryl-CoA hydrolase results in progressive infantile neurodegeneration
-
-
?
additional information
?
-
-
mutations in the gene encoding 3-hydroxyisobutyryl-CoA hydrolase results in progressive infantile neurodegeneration
-
-
?
additional information
?
-
-
enzyme production is induced in presence of Val, 2-oxoisovalerate, isobutyrate and 3-hydroxyisobutyrate. Intermediates of the Krebs cycle repress the formation of 3-hydroxyisobutyryl CoA when isobutyrate is present as the inducer. Activity is maximal at the end of the exponential phase
-
-
?
additional information
?
-
-
enzyme production is induced in presence of Val, 2-oxoisovalerate, isobutyrate and 3-hydroxyisobutyrate. Intermediates of the Krebs cycle repress the formation of 3-hydroxyisobutyryl CoA when isobutyrate is present as the inducer. Activity is maximal at the end of the exponential phase
-
-
?
