3.1.2.21: dodecanoyl-[acyl-carrier-protein] hydrolase

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For detailed information about dodecanoyl-[acyl-carrier-protein] hydrolase, go to the full flat file.

Reaction

Synonyms

12-ACP thioesterase, 12:0-ACP TE, C12:0-ACP thioesterase, Dodecanoyl-acyl-carrier-protein hydrolase, Dodecyl-acyl-carrier protein hydrolase, Hydrolase, lauroyl-[acyl carrier protein], lauroyl-ACP thioesterase, Lauroyl-acyl carrier protein thioesterase, Lauryl-acyl-carrier-protein hydrolase

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.2 Thioester hydrolases

                3.1.2.21 dodecanoyl-[acyl-carrier-protein] hydrolase

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Results	in table
5	Activating Compound
65	AA Sequence
1	CAS Registry Number
4	Cloned(Commentary)
1	General Stability
12	Inhibitors
5	Ki Value [mM]
9	KM Value [mM]
2	Localization
2	Metals/Ions
4	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
7	Organism
7	Pathway
2	PDB ID
1	pH Optimum
1	Protein Variants
2	Purification (Commentary)
1	Reaction
1	Reaction Type
7	Reference
4	Source Tissue
1	Specific Activity [micromol/min/mg]
2	Storage Stability
15	Substrates and Products (Substrate)
2	Subunits
12	Synonyms
1	Systematic Name

Engineering

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Engineering on EC 3.1.2.21 - dodecanoyl-[acyl-carrier-protein] hydrolase

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

M197E/E199H

Umbellularia californica

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the double mutant M197R/R199H has equal preference for dodecanoyl-[acyl-carrier protein] and tetradecanoyl-[acyl-carrier protein]. Mutant T231K shows no altered specificity. Mutant R327Q and R322M/R327Q have specific activities towards dodecanoyl-[acyl-carrier protein] and tetradecanoyl-[acyl-carrier protein] decreased about 100fold and 30fold. The triple mutant M197R/R199H/T231K is a tetradecanoyl-[acyl-carrier protein] thioesterase

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