3.1.15.1: venom exonuclease
This is an abbreviated version!
For detailed information about venom exonuclease, go to the full flat file.
Word Map on EC 3.1.15.1
-
3.1.15.1
-
lysophosphatidic
-
lysophospholipase
-
lysophosphatidylcholine
-
duplex
-
endonuclease
-
strand
-
metastasis
-
fibrosis
-
rnase
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single-stranded
-
nucleases
-
lysophospholipids
-
polymerases
-
polynucleotide
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phosphorothioate
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5'-nucleotidase
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adp-ribose
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adp-ribosylation
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oligodeoxynucleotides
-
pruritus
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adp-ribosyltransferase
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oligodeoxyribonucleotides
-
itch
-
phosphodiesterases
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dinucleoside
-
exonucleolytic
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ectonucleotide
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internucleotide
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phosphoramidite
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proofreading
-
deoxyribonuclease
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nucleolytic
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3'-terminus
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deoxynucleoside
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medicine
-
oligoribonucleotides
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micrococcal
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abasic
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molecular biology
-
lpa-induced
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32p-postlabeling
-
klenow
-
nuclease-resistant
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adamanteus
-
postlabeling
- 3.1.15.1
-
lysophosphatidic
- lysophospholipase
- lysophosphatidylcholine
- duplex
- endonuclease
- strand
- metastasis
- fibrosis
- rnase
-
single-stranded
- nucleases
- lysophospholipids
- polymerases
- polynucleotide
- phosphorothioate
- 5'-nucleotidase
- adp-ribose
-
adp-ribosylation
- oligodeoxynucleotides
- pruritus
- adp-ribosyltransferase
- oligodeoxyribonucleotides
-
itch
- phosphodiesterases
-
dinucleoside
-
exonucleolytic
-
ectonucleotide
-
internucleotide
-
phosphoramidite
-
proofreading
- deoxyribonuclease
-
nucleolytic
- 3'-terminus
- deoxynucleoside
- medicine
- oligoribonucleotides
-
micrococcal
-
abasic
- molecular biology
-
lpa-induced
-
32p-postlabeling
-
klenow
-
nuclease-resistant
- adamanteus
-
postlabeling
Reaction
Exonucleolytic cleavage in the 3'- to 5'- direction to yield nucleoside 5'-phosphates =
Synonyms
3'-exonuclease, 5'-exonuclease, 5'-nucleotide phosphodiesterase, alkaline phosphodiesterase, autotaxin, Crotalus adamenteus venom exonuclease, PDE, PDE-I, posphodiesterase I, snake venom phosphodiesterase, snake venom phosphodiesterase I, snake venom phosphodiesterase-I, SVP, SVPD, SVPDE, TS-PDE, venom exonuclease I, venom PDE-I, venom phosphodiesterase, venom phosphodiesterase I, VLPDE
ECTree
3.1.15.1 venom exonucleaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 3.1.15.1 - venom exonuclease
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
5'-(dCTTCA-(2'-azetidine)T-TTTTTCTTC)-3' + H2O
?
-
azetidine-T modified antisense oligonucleotide 11 degradation goes faster with respect to the antisense oligonucleotides 2-5
-
-
?
5'-(dCTTCA-(2'-N-4'-C-ethylene-bridged)T-TTTTTCTTC)-3' + H2O
?
-
2'-N,4'-C-ethylene-bridged nucleic acid thymidine modified antisense oligonucleotide 5 still remains undegraded to certain extent
-
-
?
5'-(dCTTCA-(2'-O-(2-methoxy)ethyl)T-TTTTTCTTC)-3' + H2O
?
-
for 2'-O-methyl-T modified antisense oligonucleotide 7 degradation goes faster with respect to the antisense oligonucleotides 2-5
-
-
?
5'-(dCTTCA-(2'-O-methyl)T-TTTTTCTTC)-3' + H2O
?
-
for 2'-O-methyl-T modified antisense oligonucleotide 6 degradation goes faster with respect to the antisense oligonucleotides 2-5
-
-
?
5'-(dCTTCATT-(2'-azetidine)T-TTTCTTC)-3' + H2O
?
-
azetidine-T modified antisense oligonucleotide 10 degradation goes faster with respect to the antisense oligonucleotides 2-5
-
-
?
5'-(dCTTCATT-(2'-N-4'-C-ethylene-bridged)T-TTTCTTC)-3' + H2O
?
-
2'-N,4'-C-ethylene-bridged nucleic acid thymidine modified antisense oligonucleotide 4 still remains undegraded to certain extent
-
-
?
5'-(dCTTCATTTT-(2'-azetidine)T-TCTTC)-3' + H2O
?
-
azetidine-T modified antisense oligonucleotide 8 degradation goes faster with respect to the antisense oligonucleotides 2-5
-
-
?
5'-(dCTTCATTTT-(2'-N-4'-C-ethylene-bridged)T-TCTTC)-3' + H2O
?
-
2'-N,4'-C-ethylene-bridged nucleic acid thymidine modified antisense oligonucleotide 3 still remains undegraded to certain extent
-
-
?
5'-(dCTTCATTTTTTC-(2'-azetidine)T-TC)-3' + H2O
?
-
azetidine-T modified antisense oligonucleotide 8 still remains undegraded to certain extent
-
-
?
5'-(dCTTCATTTTTTC-(2'-N-4'-C-ethylene-bridged)T-TC)-3' + H2O
?
-
2'-N,4'-C-ethylene-bridged nucleic acid thymidine modified antisense oligonucleotide 2 still remains undegraded to certain extent
-
-
?
5'-(dCTTCATTTTTTCTTC)-3' + H2O
?
-
unmodified antisense oligonucleotide 1 is completely degraded after 30 min
-
-
?
adenosine 5'-monophosphate-O-ethyl ester + H2O
adenosine 5'-monophosphate + ethanol
-
-
-
ir
adenosine 5'-O-phosphorothioate-O-p-nitrophenyl ester + H2O
adenosine-5'-O-phosphorothioate + p-nitrophenol
adenosine 5'-triphosphate + 2,2-dichloroethanol
adenosine 5'-monophosphate-O-2,2-dichloroethyl ester + H2O + diphosphate
-
-
-
ir
adenosine 5'-triphosphate + 2-chloroethanol
adenosine 5'-monophosphate-O-2-chloroethyl ester + H2O + diphosphate
-
-
-
ir
adenosine 5'-triphosphate + ethylene glycol
adenosine 5'-monophosphate-O-ethylene glycolyl ester + H2O + diphosphate
-
-
-
ir
adenosine 5'-triphosphate + glycerol
adenosine 5'-monophosphate-O-glyceryl ester + H2O + diphosphate
-
-
-
ir
adenosine 5'-triphosphate + glycerol-2-phosphate
adenosine 5'-monophosphate-O-glyceryl-2-phosphate ester + H2O + diphosphate
-
-
-
ir
adenosine 5'-triphosphate + glycerol-3-phosphate
adenosine 5'-monophosphate-O-glyceryl-3-phosphate ester + H2O + diphosphate
-
-
-
ir
adenosine 5'-triphosphate + methanol
adenosine 5'-monophosphate-O-methyl ester + H2O + diphosphate
-
-
-
ir
adenosine 5'-triphosphate + propanol
adenosine 5'-monophosphate-O-propyl ester + H2O + diphosphate
-
-
-
ir
dinucleotide monophosphates + H2O
nucleoside + nucleoside 5'-monophosphate
-
with 2'-5', 3'-5', or 5'-5' linkages
-
?
dinucleotides with 3'-phosphoryl terminus + H2O
nucleosides + 3',5'-diphosphonucleotides
-
-
-
?
oligonucleotides with 3'-phosphoryl terminus + H2O
nucleosides + 3',5'-diphosphonucleotides
-
-
-
?
p-nitrophenyl thymidine 5'-phosphate + H2O
5'-TMP + p-nitrophenol
-
-
-
-
?
4-nitrophenyl thymidine-5'-phosphate + H2O
4-nitrophenol + thymidine-5'-phosphate
-
-
-
-
?
4-nitrophenyl thymidine-5'-phosphate + H2O
4-nitrophenol + thymidine-5'-phosphate
best substrate
-
-
?
adenosine 5'-O-phosphorothioate-O-p-nitrophenyl ester + H2O
adenosine-5'-O-phosphorothioate + p-nitrophenol
-
-
-
?
adenosine 5'-O-phosphorothioate-O-p-nitrophenyl ester + H2O
adenosine-5'-O-phosphorothioate + p-nitrophenol
Crotalus terrificus terrificus
-
-
-
-
?
p-nitrophenylthymidine-5'-phosphate + H2O
5'-TMP + p-nitrophenol
-
requirement of 3'-hydroxyl group
-
?
p-nitrophenylthymidine-5'-phosphate + H2O
5'-TMP + p-nitrophenol
-
requirement of 3'-hydroxyl group
-
?
p-nitrophenylthymidine-5'-phosphate + H2O
5'-TMP + p-nitrophenol
-
requirement of 3'-hydroxyl group
-
?
p-nitrophenylthymidine-5'-phosphate + H2O
5'-TMP + p-nitrophenol
-
-
-
?
p-nitrophenylthymidine-5'-phosphate + H2O
5'-TMP + p-nitrophenol
-
requirement of 3'-hydroxyl group
-
?
p-nitrophenylthymidine-5'-phosphate + H2O
5'-TMP + p-nitrophenol
-
requirement of 3'-hydroxyl group
-
?
p-nitrophenylthymidine-5'-phosphate + H2O
5'-TMP + p-nitrophenol
-
requirement of 3'-hydroxyl group
-
?
p-nitrophenylthymidine-5'-phosphate + H2O
5'-TMP + p-nitrophenol
-
requirement of 3'-hydroxyl group
-
?
p-nitrophenylthymidine-5'-phosphate + H2O
5'-TMP + p-nitrophenol
-
requirement of 3'-hydroxyl group
-
?
p-nitrophenylthymidine-5'-phosphate + H2O
5'-TMP + p-nitrophenol
-
requirement of 3'-hydroxyl group
-
?
polynucleotide + H2O
5'-nucleotides
-
no hydrolysis of nuceotides in syn configuration
-
?
additional information
?
-
-
3' strand-break termini can be digested by SVPD. Strand-break termini can be recognized directly and digested by SVPD without calf intestine alkaline phosphatase pretreatment, whereas other termini cannot be digested by SVPD without calf intestine alkaline phosphatase pretreatment
-
-
?
additional information
?
-
-
digests 70-kDa protein of the clinical Helicobacter pylori isolate OMH4 and 55-kDa and 45-kDa proteins of human gastric carcinoma, releases only AMP
-
-
?
additional information
?
-
-
oligodeoxynucleotides containing 1,8-naphthyridine C-nucleoside and imidazo[5',4':4,5]pyrido[2,3-d]pyrimidine nucleoside at the terminal positions are 6-40times more resistant than natural DNA to SVPD digestion despite possessing a natural phosphodiester linkage
-
-
?
additional information
?
-
-
the enzyme has the unique ability as an exonuclease to sequentially cleave one nucleotide from single-stranded DNA, MALDI-TOF mass spectrometric analysis of reaction products
-
-
?
additional information
?
-
-
alcohol competes with water in esterification, so that adenosine 5'monophosphate can also be a product
-
-
?
additional information
?
-
-
alcohol competes with water in esterification, so that adenosine 5'monophosphate can also be a product
-
-
?
additional information
?
-
the enzyme hydrolyses ADP but not ATP and 5'-AMP, the enzyme inhibits aggregation of platelets induced by ADP or collagen
-
-
?
additional information
?
-
-
the enzyme hydrolyses ADP but not ATP and 5'-AMP, the enzyme inhibits aggregation of platelets induced by ADP or collagen
-
-
?
additional information
?
-
-
the enzyme also exhibits DNase activity
-
-
?
additional information
?
-
-
the purified enzyme TS-PDE exhibits exonuclease activity with a broad phosphodiesterase substrate range with the descending order of specificity: nicotinamide guanine dinucleotide, ATP, nicotinamide adenine dinucleotide, ADP
-
-
?
additional information
?
-
-
the enzyme sequentially removes mononucleotide units from the polynucleotide chain starting from the free 3' hydroxyl end, and can attack DNA, RNA, or any nucleotide chain
-
-
?
