3.1.11.5: exodeoxyribonuclease V
This is an abbreviated version!
For detailed information about exodeoxyribonuclease V, go to the full flat file.
Word Map on EC 3.1.11.5
Reaction
Exonucleolytic cleavage (in the presence of ATP) in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides =
Synonyms
AddAB enzyme, E. coli ATP-dependent DNase, E. coli exonuclease V, Escherichia coli exonuclease V, Escherichia coli RecBCD, Exodeoxyribonuclease V 125 kDa polypeptide, Exodeoxyribonuclease V 135 KDA polypeptide, Exodeoxyribonuclease V 67 kDa polypeptide, exonuclease V, ExoV, gene recBC DNase, gene RecBC endoenzyme, nuclease, exodeoxyribo V, PAB2263, RecB, RecB helicase-nuclease, REcB30 protein, recBC deoxyribonuclease, recBC DNase, recBC nuclease, RecBCD, RecBCD DNase, recBCD enzyme, RecBCD exonuclease, RecBCD-type helicase-nuclease, RecD, UPF0286 protein PYRAB01260
ECTree
3.1.11.5 exodeoxyribonuclease VAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 3.1.11.5 - exodeoxyribonuclease V
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
double-stranded DNA
single stranged DNA
-
unwinding of double-stranded DNA
substrate for the DNA strand-exchange protein, RecA
?
double-stranded DNA
single-stranded DNA
-
ATP-dependent, unwinding of DNA molecule
-
?
douple-stranded DNA
?
-
the enzyme is required for the major pathway of double-strand DNA break repair and genetic exchange, the enzyme has potent nuclease and helicase activity
-
?
ATP + H2O
ADP + phosphate
-
-
-
-
?
double-stranded DNA
single-stranded DNA fragments
-
the enzyme plays a an important role in the initiation of DNA recombination and recombinant-dependent DNA replication
-
?
double-stranded DNA
single-stranded DNA fragments
-
the enzyme plays a an important role in the initiation of DNA recombination and recombinant-dependent DNA replication
-
?
double-stranded DNA + H2O
single-stranded DNA fragments
-
responsible for several steps in genetic recombination process
-
-
?
double-stranded DNA + H2O
single-stranded DNA fragments
-
ATP-dependent exonuclease
133994, 133995, 133996, 133997, 133998, 133999, 134000, 134001, 134002, 134003, 134004, 134012, 134013, 134023, 134025, 134026, 134027, 134028, 134029, 134030, 134031
-
-
?
double-stranded DNA + H2O
single-stranded DNA fragments
-
ATP-dependent helicase
-
-
?
double-stranded DNA + H2O
single-stranded DNA fragments
-
-
-
-
?
double-stranded DNA + H2O
single-stranded DNA fragments
-
-
-
-
?
double-stranded DNA + H2O
single-stranded DNA fragments
-
-
-
-
?
single stranded DNA + H2O
5'-phosphomonoester oligonucleotides
-
-
-
-
?
single stranded DNA + H2O
5'-phosphomonoester oligonucleotides
-
-
-
-
?
single stranded DNA + H2O
5'-phosphomonoester oligonucleotides
-
-
-
-
?
single stranded DNA + H2O
5'-phosphomonoester oligonucleotides
-
ATP-dependent exonuclease
-
-
?
single stranded DNA + H2O
5'-phosphomonoester oligonucleotides
-
ATP-dependent endonuclease
-
-
?
single stranded DNA + H2O
5'-phosphomonoester oligonucleotides
-
ATP-stimulated endonuclease
-
-
?
single stranded DNA + H2O
5'-phosphomonoester oligonucleotides
-
-
-
-
?
single stranded DNA + H2O
5'-phosphomonoester oligonucleotides
-
-
-
-
?
single stranded DNA + H2O
5'-phosphomonoester oligonucleotides
-
-
-
-
?
single stranded DNA + H2O
5'-phosphomonoester oligonucleotides
-
-
-
-
?
single stranded DNA + H2O
5'-phosphomonoester oligonucleotides
-
-
-
-
?
additional information
?
-
the RecA protein loading is an essential function of the enzyme
-
?
additional information
?
-
-
first: The enzyme is a potent double-stranded DNA exonuclease that destroys linear DNA produced by restriction of foreign DNA. second: The enzyme promotes repair of double-stranded DNA breaks and genetic recombination in the vicinity of chi recombination hotspots.
-
?
additional information
?
-
-
the activities of enzyme responsible for the initiation of recombinantional and repair processes are required for UV-induced restriction alleviation
-
?
additional information
?
-
-
The enzyme is involved in the radiation-induced process know as prophage inactivation. The helicase activity of enzyme is responsible for the progressive loss of prophage recombinogenicity. This loss is most probably a consequence of the unsuccessful enzyme-dependent recombinational repair of double-stranded breaks in the cell chromosome, during which some structures unsuitable for further recombination reactions may be produced.
-
?
additional information
?
-
-
RecD protein expression level is decreased at lower cultivation temperature, which greatly improves the productivity of cell-free protein synthesis from linear DNA templates
-
-
?
additional information
?
-
RecBCD degradation of DNA is inhibited by either cisplatin-damaged or UV-damaged DNA sequences
-
-
?
