3.1.1.8: cholinesterase

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For detailed information about cholinesterase, go to the full flat file.

Reaction

Synonyms

acyl choline acylhydrolase, acylcholine acyl-hydrolase, Acylcholine acylhydrolase, atypical cholinesterase, BChE, benzoylcholinesterase, BoBChE, BTCh, BTChI-ChE, BtChoEase, BuChE, butyrocholinesterase, butyryl-ChE, butyrylChE, butyrylcholine esterase, butyrylcholine-hydrolyzing enzyme, butyrylcholinesterase, butyrylcholinesterase K, calcium-activated butyrylcholinesterase, ChE, ChE-II, CholE, choline esterase, choline esterase II (unspecific), cholinesterase, dBChE, DjChE, Djche1, Djche2, EQ-BCHE, eqBChE, EqBuChE, esterase, butyrylcholine, esterase, choline, hBChE, HuBChE, mBuChE I, mBuChE II, monomeric butyrylcholinesterase I, monomeric butyrylcholinesterase II, More, non specific cholinesterase, non-specific cholinesterase, PChE, planarian cholinesterase, plasma cholinesterase, plasma esterase, plasmatic cholinesterase, PoBChE, propionylcholinesterase, pseudo choline esterase, pseudo cholinesterase, pseudocholinesterase, PTChI-ChE, rBChE, serum cholinesterase

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.1 Carboxylic-ester hydrolases

                3.1.1.8 cholinesterase

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Results	in table
26	Activating Compound
30	AA Sequence
17	Application
1	CAS Registry Number
28	Cloned(Commentary)
8	Crystallization (Commentary)
13920	Disease/ Diagnostics
4	Expression
25	General Information
4	General Stability
605	IC50 Value
1641	Inhibitors
18	kcat/KM [mM/s]
215	Ki Value [mM]
228	KM Value [mM]
50	Localization
4	Metals/Ions
33	Molecular Weight [Da]
135	Natural Substrates/ Products (Substrates)
309	Organism
102	PDB ID
95	pH Optimum
9	pH Range
4	pH Stability
10	Posttranslational Modification
87	Protein Variants
41	Purification (Commentary)
15	Reaction
1	Reaction Type
309	Reference
328	Source Tissue
80	Specific Activity [micromol/min/mg]
18	Storage Stability
555	Substrates and Products (Substrate)
37	Subunits
427	Synonyms
1	Systematic Name
80	Temperature Optimum [°C]
1	Temperature Range [°C]
19	Temperature Stability [°C]
103	Turnover Number [1/s]

pH Range

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pH Range on EC 3.1.1.8 - cholinesterase

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pH RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

5

Homo sapiens

-

enzyme retains activity at pH 5 and below under conditions of excess substrate activation

651156

5 - 7.5

Equus caballus

-

a decrease in pH from 7.5 to 5.0 is accompanied by a 20fold drop in the rate of enzymatic hydrolysis of acetylcholine and a 5fold decrease in the case of phenylacetate. In the case of indophenyl acetate and 2,6-dichlorophenolindophenyl acetate, only a 2.5fold decrease is detected

714817

5 - 8

Oryza sativa

-

the enzyme shows very low (but non-zero) activity at pH 5.0, with a gradual rise in activity to pH 8.0

750130

5.5 - 8.5

3 entries

6 - 10

Vigna radiata var. radiata

-

pH 6.0 and pH 10.0 25% of maximal activity

94434

6 - 8.5

Homo sapiens

-

increasing activity with increasing pH

651173

6.5 - 8.5

Pseudopleuronectes yokohamae

-

80% of maximal activity within this range

681741

5.5 - 8.5

Equus caballus

-

soluble and immobilized enzyme

94446

5.5 - 8.5

Homo sapiens

P06276

kcat with both cocaine stereoisomers is pH dependent in A328W/Y332A mutant, whereas that of wild-type enzyme is pH dependent only with the unnatural isomer, kcat increases with increasing pH

653283

5.5 - 8.5

Homo sapiens

-

no pH dependence of kcat for (-)-cocaine, kcat for (+)-cocaine increases up to pH 7 and decreases above pH 7, Km of both stereoisomers decreases up to pH 8

652220