3.1.1.8: cholinesterase
This is an abbreviated version!
For detailed information about cholinesterase, go to the full flat file.
Word Map on EC 3.1.1.8
-
3.1.1.8
-
ache
-
alzheimer
-
cholinergic
-
acetylcholine
-
organophosphate
-
nerve
-
dementia
-
pesticide
-
poison
-
donepezil
-
organophosphorus
-
insecticide
-
erythrocyte
-
physostigmine
-
deficit
-
atropine
-
neuromuscular
-
carbamate
-
rivastigmine
-
muscarinic
-
intoxication
-
neurotoxicity
-
amyloid
-
nicotinic
-
galantamine
-
tacrine
-
neuroprotective
-
oxime
-
placebo
-
innervation
-
carboxylesterase
-
chlorpyrifos
-
soman
-
memantine
-
caregiver
-
mini-mental
-
antipsychotic
-
esterases
-
parathion
-
placebo-controlled
-
myasthenia
-
anticholinergic
-
paraoxon
-
dfp
-
scopolamine
-
antidote
-
gravis
-
subscale
-
delirium
-
medicine
-
pharmacology
-
environmental protection
-
drug development
-
diagnostics
-
analysis
-
hallucinations
-
biotechnology
- 3.1.1.8
-
ache
- alzheimer
-
cholinergic
- acetylcholine
-
organophosphate
- nerve
- dementia
-
pesticide
-
poison
- donepezil
-
organophosphorus
-
insecticide
- erythrocyte
- physostigmine
- deficit
- atropine
- neuromuscular
- carbamate
- rivastigmine
-
muscarinic
-
intoxication
-
neurotoxicity
-
amyloid
-
nicotinic
- galantamine
- tacrine
-
neuroprotective
- oxime
-
placebo
-
innervation
- carboxylesterase
- chlorpyrifos
- soman
- memantine
-
caregiver
-
mini-mental
-
antipsychotic
- esterases
- parathion
-
placebo-controlled
- myasthenia
-
anticholinergic
- paraoxon
- dfp
- scopolamine
-
antidote
- gravis
-
subscale
- delirium
- medicine
- pharmacology
- environmental protection
- drug development
- diagnostics
- analysis
- hallucinations
- biotechnology
Reaction
Synonyms
acyl choline acylhydrolase, acylcholine acyl-hydrolase, Acylcholine acylhydrolase, atypical cholinesterase, BChE, benzoylcholinesterase, BoBChE, BTCh, BTChI-ChE, BtChoEase, BuChE, butyrocholinesterase, butyryl-ChE, butyrylChE, butyrylcholine esterase, butyrylcholine-hydrolyzing enzyme, butyrylcholinesterase, butyrylcholinesterase K, calcium-activated butyrylcholinesterase, ChE, ChE-II, CholE, choline esterase, choline esterase II (unspecific), cholinesterase, dBChE, DjChE, Djche1, Djche2, EQ-BCHE, eqBChE, EqBuChE, esterase, butyrylcholine, esterase, choline, hBChE, HuBChE, mBuChE I, mBuChE II, monomeric butyrylcholinesterase I, monomeric butyrylcholinesterase II, More, non specific cholinesterase, non-specific cholinesterase, PChE, planarian cholinesterase, plasma cholinesterase, plasma esterase, plasmatic cholinesterase, PoBChE, propionylcholinesterase, pseudo choline esterase, pseudo cholinesterase, pseudocholinesterase, PTChI-ChE, rBChE, serum cholinesterase
ECTree
3.1.1.8 cholinesteraseAdvanced search results
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results (Substrates Products
Substrates Products on EC 3.1.1.8 - cholinesterase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2,2,2-trifluoro-N-(2-nitrophenyl)acetamide + H2O
2-nitroaniline + trifluoroacetate
-
a neutral amide
-
-
?
2,6-dichloro-3'-methylindophenylacetate + H2O
2,6-dichloro-3'-methylindophenol + acetate
-
-
-
?
2,6-dichlorophenolindophenylacetate + H2O
2,6-dichlorophenolindophenol + acetate
-
good substrate
-
?
3',5'-dichloro-2'-methylindophenylacetate + H2O
3',5'-dichloro-2'-methylindophenol + acetate
-
weak substrate
-
?
3',5'-dichlorophenolindophenylacetate + H2O
3',5'-dichlorophenolindophenol + acetate
-
-
-
?
3-(acetamido) N,N,N-trimethylanilinium + H2O
3-amino-N,N,N-trimethylanilinium + acetate
-
a positively charged amide, hydrolysis by the wild-type enzyme and the mutant D70G shows a long transient phase preceeding the steady state, hysteretic burst induction phase, overview
-
-
?
7-ethyl-10-[4-(1-piperidine)-1-piperidino]carbonyloxycamtothecin + H2O
7-ethyl-10-hydroxycamptothecin + ?
anticancer drug irinotecan CPT-11
-
?
acetyl choline + H2O
acetate + choline
-
enzyme also acts on acetyl choline to a lesser extent
-
?
acetylthiocholine + H2O
?
-
detection with 5,5-dithiobis(2-nitrobenzoic acid)
-
-
?
adipyldicholine + H2O
adipic acid + choline
lower activity, monitoring the dicholine substrates, the monocholine intermediates, the dicarboxylic acid and choline products by mass spectrometry,
-
-
?
BChE-FP + H2O
?
-
structure-based design and application of a fluorogenic molecular probe, BChE-FP, specific to butyrylcholinesterase (BChE). This compound is rationally designed by mimicking the native substrate and optimized stepwise by manipulating the steric feature and the reactivity of the designed probe targeting the structural difference of the active pockets of BChE and acetylcholinesterase (AChE). The refined probe, BChE-FP, exhibits high specificity toward BChE compared to AChE, producing about 275fold greater fluorescence enhancement upon the catalysis by BChE, molecular docking simulation, overview. The proximity of Ser198 to the carbonyl group of BChE-FP is about 4.3 A in the BChE active site, whereas the proximity of Ser203 to the carbonyl group of BChE-FP is about 7.4 A in the AChE active site. The binding affinity of BChE-FP with BChE is B100fold greater than that of acetylthiocholine, while the catalytic constant for BChE-FP is 190fold lower than that of acetylthiocholine
-
-
?
ethyl ([2-[bis(propan-2-yl)amino]ethyl]-sulfanyl)(methyl)phosphinate + H2O
?
substrate for mutant enzyme G117H
-
-
?
formylthiocholine + H2O
thiocholine + formate
via formation of the tetrahedral intermediate, measurement of heavy atom kinetic isotope effects
-
-
?
isoamyl isovalerate + H2O
isopentanol + isopentanoate
-
poor substrate
-
-
?
isobutyl isovalerate + H2o
isobutanol + isopentanoate
-
poor substrate
-
-
?
isobutyl propionate + H2O
isobutanol + propanoate
-
poor substrate
-
-
?
n-amyl n-butyrate + H2O
n-pentanol + n-butanoate
-
good substrate
-
-
?
n-butyl n-butyrate + H2O
n-butanol + n-butanoate
-
poor substrate
-
-
?
N-methyl-(7-dimethylcarbamoxy)quinolinium iodide + H2O
?
-
atypical and usual enzyme
-
-
?
o-nitrophenylbutyrate + H2O
o-nitrophenol + butanoate
-
atypical and usual enzyme
-
-
?
propionyl choline + H2O
propionate + choline
-
preferred substrate
-
?
propionylthiocholine iodide + H2O
thiocholine + propionate
-
preferred substrate
-
-
?
S-butyrylthiocholine iodide + H2O
butyrate + thiocholine iodide
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
-
?
sebacyldicholine + H2O
sebacic acid + choline
high activity, monitoring the dicholine substrates, the monocholine intermediates, the dicarboxylic acid and choline products by mass spectrometry, sebacyldicholine is hydrolyzed at both choline ester sites, though hydrolysis of dicholine is faster than hydrolysis of monocholine, overview
-
-
?
(-)-cocaine + H2O
?
-
unique role of the oxyanion hole G116/G117/A199 in hydrolysis of cocaine, molecular dynamics simulation
-
-
?
acetyl-beta-methylcholine
beta-methylcholine + acetate
Pseudomonas aeruginosa Kitasato / ATCC 25102
-
-
-
-
?
acetyl-beta-methylcholine + H2O
acetate + beta-methylcholine
-
poor substrate
-
-
?
acetyl-beta-methylcholine + H2O
acetate + beta-methylcholine
-
acetyl-beta-methylcholine chloride
-
-
?
acetyl-beta-methylcholine + H2O
acetate + beta-methylcholine
-
poor substrate
-
-
?
acetyl-beta-methylthiocholine + H2O
beta-methylthiocholine + acetate
-
75% activity compared to acetylthiocholine
-
-
?
acetyl-beta-methylthiocholine + H2O
beta-methylthiocholine + acetate
-
60.7-81.4% activity compared to acetylthiocholine
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
-
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
detection using 5,5'-dithiobis(2-nitrobenzoic acid)
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
-
detection using 5,5'-dithiobis(2-nitrobenzoic acid)
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
-
detection using 5,5'-dithiobis(2-nitrobenzoic acid)
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
Pseudomonas aeruginosa Kitasato / ATCC 25102
-
-
-
-
?
acetylthiocholine + H2O
acetate + thiocholine
-
maximal activity at 0.15 mM, inhibition at higher concentrations
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
preferred substrate
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
some step (or steps) other than chemical formation of the tetrahedral intermediate are partially rate determining
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
100fold lower binding activity compared to butyrylthiocholine
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
preferred substrate, 100% activity
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
increasing activity with substrates in the following order: acetylthiocholine, propionylthiocholine, butyrylthiocholine
-
?
acetylthiocholine + H2O
thiocholine + acetate
-
enzyme BChE may hydrolyze in some extent the substrate acetylthiocholine, ASCh
-
-
?
benzoylcholine + H2O
choline + benzoate
-
rate-limiting step for hydrolysis is deacylation, k3
-
-
?
benzoylthiocholine + H2O
thiocholine + benzoate
-
rate-limiting step for hydrolysis is acylation, k2
-
-
?
butyrylthiocholine + H2O
?
-
detection by 5,5-dithiobis(2-nitrobenzoic acid)
-
-
?
butyrylthiocholine + H2O
butanoate + thiocholine
-
butyrylthiocholine iodide
-
-
?
butyrylthiocholine + H2O
butanoate + thiocholine
-
butyrylthiocholine iodide
-
-
?
butyrylthiocholine + H2O
butanoate + thiocholine
-
butyrylthiocholine iodide
-
-
?
butyrylthiocholine + H2O
butanoate + thiocholine
-
butyrylthiocholine iodide
-
-
?
butyrylthiocholine + H2O
butanoate + thiocholine
-
good substrate
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
-
detection using 5,5'-dithiobis(2-nitrobenzoic acid)
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
-
-
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
-
BuChE activity is decreased in Alzehimer's disease patients compared to healthy persons, overview
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
-
detection by 5,5-dithiobis(2-nitrobenzoic acid)
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
-
detection using 5,5'-dithiobis(2-nitrobenzoic acid)
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
detection using 5,5'-dithiobis(2-nitrobenzoic acid)
-
-
?
butyrylthiocholine + H2O
butyrate + thiocholine
-
detection using 5,5'-dithiobis(2-nitrobenzoic acid)
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
-
butyrylthiocholine iodide, low activity
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
-
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
-
-
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
-
BuChE catalyses the hydrolysis of numerous endogenous substances, including choline esters and the growth hormone secretagogue, octanoyl ghrelin and has an important role in Alzheimers disease
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
-
the enzyme might be involved in slowing of neurodegeneration in Alzheimers and Parkinsons diseases, overview
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
-
substrate as butyrylthiocholine iodide
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
-
best enzyme for the wild type enzyme
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
-
histochemic activity detection
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
substrate is butyrylthiocholine iodide, activity detection using 5,5'-dithio-bis(2-nitrobenzoic acid) colorimetric assay and measurement of the absorbance at 412 nm
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
-
preferred substrate
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
-
74% activity compared to acetylthiocholine
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
-
1.4-15.8% activity compared to acetylthiocholine
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
-
low activity
-
-
?
butyrylthiocholine + H2O
thiocholine + butyrate
-
increasing activity with substrates in the following order: acetylthiocholine, propionylthiocholine, butyrylthiocholine
-
?
butyrylthiocholine iodide + H2O
butyrate + thiocholine iodide
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
-
?
butyrylthiocholine iodide + H2O
butyrate + thiocholine iodide
-
detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB
-
-
?
butyrylthiocholine iodide + H2O
thiocholine iodide + butyrate
-
-
-
-
?
butyrylthiocholine iodide + H2O
thiocholine iodide + butyrate
-
-
-
?
butyrylthiocholine iodide + H2O
thiocholine iodide + butyrate
-
-
-
-
?
propionylcholine + H2O
propanoate + choline
Pseudomonas aeruginosa Kitasato / ATCC 25102
-
-
-
-
?
propionylthiocholine + H2O
?
-
detection by 5,5-dithiobis(2-nitrobenzoic acid)
-
-
?
propionylthiocholine + H2O
propanoate + thiocholine
-
propionylthiocholine iodide
-
-
?
propionylthiocholine + H2O
propanoate + thiocholine
-
propylthiocholine
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
-
propionylthiocholine iodide, preferred substrate
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
-
80% activity compared to acetylthiocholine
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
-
40.6-43.5% activity compared to acetylthiocholine
-
-
?
propionylthiocholine + H2O
thiocholine + propionate
-
best substrate
-
?
propionylthiocholine + H2O
thiocholine + propionate
-
increasing activity with substrates in the following order: acetylthiocholine, propionylthiocholine, butyrylthiocholine
-
?
succinyl dicholine dichloride + H2O
?
-
yolk cholinesterase 1 and 2 and blood plasma cholinesterase poor substrate
-
-
?
succinyl dicholine dichloride + H2O
?
-
liver cholinesterase 1 and 2 no substrate
-
-
?
additional information
?
-
-
tissue specificity of enzyme activities with different substrates, overview
-
-
?
additional information
?
-
-
tissue specificity of enzyme activities with different substrates, overview
-
-
?
additional information
?
-
-
tissue specificity of enzyme activities with different substrates, overview
-
-
?
additional information
?
-
-
the cholinesterase also shows activity with acetylthiocholine, and acetylcholine, cf. EC 3.1.1.7
-
-
?
additional information
?
-
BoBChE has 3fold higher activity with butyrylthiocholine than with acetylthiocholine
-
-
?
additional information
?
-
-
BoBChE has 3fold higher activity with butyrylthiocholine than with acetylthiocholine
-
-
?
additional information
?
-
-
the Dugesia japonica enzyme DjChE has intermediate features of acetylcholinesterase (AChE, EC 3.1.1.7) and butyrylcholinesterase (BChE). Two candidate genes, Djche1 and Djche2, are responsible for DjChE activity
-
-
?
additional information
?
-
-
rat plasma BuChE is increased when pretreated with horse BuChE
-
-
?
additional information
?
-
-
hydrolysis of diverse esters and thioesters with various structures of alkyl bridge between esteric atom and ammonium grouping with common formula R1-(O)-X-CHR2-CHR3-C, and of acylates and thioacylates of ammonium derivatives with common formula R1-(O)-X-R2, and of acetates and thioacetates with various structures of ammonium grouping with common formula CH3C(O)-X-CH2CH2-R, overview
-
-
?
additional information
?
-
the observed heavy atom kinetic isotope effects of butyrylcholinesterase-catalyzed hydrolysis of formylthiocholine support a mechanism for both acylation and deacylation where the steps up to and including the formation of the tetrahedral intermediate are at least partially rate determining. The first irreversible step is the product release in acylation
-
-
?
additional information
?
-
-
feline plasma contains multiple forms of the enzyme
-
-
?
additional information
?
-
-
atypical and usual enzymes differ only in the structure of their anionic site
-
-
?
additional information
?
-
-
limited alpha-chymotrypsin digestion of purified enzyme exhibits cholinesterase, acryl acylamidase, and peptidase activities
-
-
?
additional information
?
-
-
human atypical butyrylcholinesterase is a variant with an aspartic acid to glycine substitution at position 70
-
-
?
additional information
?
-
-
butyrylcholine is not a physiological substrate, enzyme may replace acetylcholine esterase in hydrolysing brain acetylcholine in patients with advanced stages of Alzheimer's disease
-
?
additional information
?
-
-
causes a concentration-dependent enhancement of the catalytic activity of trypsin, may assume a regulatory role by interacting with other proteins
-
?
additional information
?
-
the oxoanion hole of enzyme can lower the energy barrier for the acetylcholine hydrolysis significantly more than that for cocaine hydrolysis
-
-
?
additional information
?
-
-
the oxoanion hole of enzyme can lower the energy barrier for the acetylcholine hydrolysis significantly more than that for cocaine hydrolysis
-
-
?
additional information
?
-
-
calcium-activated butyrylcholinesterase as a major protective mechanism against suicide inhibition of acetylcholinesterase by organophosphates in this non-neuronal tissue
-
-
?
additional information
?
-
-
the enzyme is assessed as a marker for liver pathologies, patients with diminished BChE activity do not have increased BChE aryl acylamidase activity, but the overall aryl acylamidase activity is increased, overview
-
-
?
additional information
?
-
-
BChE also shows aryl acylamidase activity, i.e. AAA activity, the rate-determining step of which is the acylation, overview
-
-
?
additional information
?
-
-
structure-activity relationships and kinetic studies, overview, the enzyme also shows an aryl acylamidase activity, EC 3.5.1.13, whereby it catalyzes the hydrolysis of amides of certain aromatic amines, BuChE shows high activity with larger N-(2-nitrophenyl)alkylamides, the ester and anilide substrates compete for the some catalytic site, no significant hydrolysis of the anilide takes place until the preferred choline ester hydrolysis is completed, overview
-
-
?
additional information
?
-
-
BChE tetramers from human plasma are associated with proline-rich peptides derived froma cytoplasmic protein, lamellipodin or RAPH1. BChE does exert a toxic effect on cultured neurons
-
-
?
additional information
?
-
-
butyrylcholinesterase is important in human cocaine metabolism despite its limited ability to hydrolyze this drug, it is a major contributor to cocaine metabolism and detoxification
-
-
?
additional information
?
-
hBChE is primarily involved in neuronal transmission and is a potential bioscavenger of toxic organophosphates to protect acetylcholinesterase
-
-
?
additional information
?
-
-
hBChE is primarily involved in neuronal transmission and is a potential bioscavenger of toxic organophosphates to protect acetylcholinesterase
-
-
?
additional information
?
-
-
inhibition of BChE, along with the acetylcholinesterase, and restoration of acetylcholine is a therapeutic strategy in treatment of Alzheimer's disease and other forms of dementia
-
-
?
additional information
?
-
-
relationship between K variant of gene BCHE genotype and butyrylcholinesterase activity in autopsy brain tissue, BuChE activity in temporal cortex is 37% higher in K homozygotes than in wild-type homozygotes, overview
-
-
?
additional information
?
-
-
the butyrylcholinesterase detoxifies racemic soman, but to a lower rate and less enantioselective than acetylcholinesterase, EC 3.1.1.7, overview
-
-
?
additional information
?
-
-
the enzyme participates in neurogenesis and neurite growth in neurons and glia, and prolongates the ThT lag time and reduces the apparent rate of beta-amyloid-fibril formation compared to beta-amyloid alone
-
-
?
additional information
?
-
-
BuChE reacts stoichiometrically with organophosphosphorus esters, overview
-
-
?
additional information
?
-
butyrylcholinesterase hydrolyzes long chain dicholine esters more rapidly than short chain dicholine esters. The active site of butyrylcholinesterase contains the catalytic residue Ser198 and is deeply buried within the enzyme molecule and there is limited space for binding of large compounds, three-step binding model for hydrolysis of positively charged substrates by BuChE, overview
-
-
?
additional information
?
-
-
butyrylcholinesterase hydrolyzes long chain dicholine esters more rapidly than short chain dicholine esters. The active site of butyrylcholinesterase contains the catalytic residue Ser198 and is deeply buried within the enzyme molecule and there is limited space for binding of large compounds, three-step binding model for hydrolysis of positively charged substrates by BuChE, overview
-
-
?
additional information
?
-
-
in addition to the hydrolysis of acetylcholine and other esters, acetylcholinesterase and BChE hydrolyze arylacylamides, although at a much lower rate
-
-
?
additional information
?
-
-
the enzyme shows in addition to its esterase activity also aryl acylamidase activity, EC 3.5.1.13, hydrolyzing 2-nitroacetanilide and its trifluoro-derivative, the ratio of the two activities depends on the tissue source and oligomeric state of the enzyme, the aryl acylamidase activity is low for tetramers, but increased for monomeric enzyme, overview
-
-
?
additional information
?
-
butyrylthiocholine iodide substrate is incubated with the enzyme and the reaction is terminated by the addition of Ellman's reagent (5,5'-dithiobis(2-nitrobenzoic acid), DTNB), at which point the change in the absorbance at 412 nm is spectroscopically measured
-
-
?
additional information
?
-
substrate specificities compared to acetylcholinesterase (EC 3.1.1.7) and cocaine esterase (EC 3.1.1.84)
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additional information
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tissue specificity of enzyme activities with different substrates, overview
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additional information
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different forms of enzyme, solubilized by different extraction media, are hydrosoluble, detergent-soluble and HIS-soluble
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additional information
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the enzyme is involved in the morphogenetic processes of neuronal and non-neuronal tissues
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additional information
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butyrylcholinesterase to acetylcholinesterase ratio in mouse sera decreases from 6:1 in wild-type control to 3:1 in mdx-mice
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additional information
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embryonic butyrylcholinesterase is typically found in cells engaged in proliferation processes
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additional information
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in vitro effects of environmental contaminants on enzyme activities, overview
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additional information
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enzyme exhibits an amine sensitive aryl acylamidase, AAA, and a metallocarboxypeptidase activity
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additional information
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butyryl esters are hydrolyzed at a greater rate than propionyl, pentanoyl, valeryl- or acetyl esters
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additional information
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enzyme and phosphorylcholine phosphatase coordinately contribute to the breakdown of the corneal epithelial membrane upon infection
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additional information
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very bad substratets: butyrylcholine, succinylcholine
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additional information
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Pseudomonas aeruginosa Kitasato / ATCC 25102
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very bad substratets: butyrylcholine, succinylcholine
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?
additional information
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hydrolysis of benzoylcholine and its N-alkyl derivatives shows hysteretic pre-steady-state phase of induction. Hysteresis is complex and consists of lag phase superimposed on damped oscillations
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additional information
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BChE hydrolyzes a wider range of esters but preferentially S-butyrylthiocholine iodide (BSCh)
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additional information
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PoBChE hydrolyzes acetylthiocholine slightly faster than butyrylthiocholine
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additional information
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PoBChE hydrolyzes acetylthiocholine slightly faster than butyrylthiocholine
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additional information
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the cholinesterase also shows activity with acetylthiocholine, and acetylcholine, cf. EC 3.1.1.7
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additional information
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enzyme occurs in multiple molecular forms
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