Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.1.1.8: cholinesterase

This is an abbreviated version!
For detailed information about cholinesterase, go to the full flat file.

Word Map on EC 3.1.1.8

Reaction

an acylcholine
+
H2O
=
choline
 +
a carboxylate

Synonyms

acyl choline acylhydrolase, acylcholine acyl-hydrolase, Acylcholine acylhydrolase, atypical cholinesterase, BChE, benzoylcholinesterase, BoBChE, BTCh, BTChI-ChE, BtChoEase, BuChE, butyrocholinesterase, butyryl-ChE, butyrylChE, butyrylcholine esterase, butyrylcholine-hydrolyzing enzyme, butyrylcholinesterase, butyrylcholinesterase K, calcium-activated butyrylcholinesterase, ChE, ChE-II, CholE, choline esterase, choline esterase II (unspecific), cholinesterase, dBChE, DjChE, Djche1, Djche2, EQ-BCHE, eqBChE, EqBuChE, esterase, butyrylcholine, esterase, choline, hBChE, HuBChE, mBuChE I, mBuChE II, monomeric butyrylcholinesterase I, monomeric butyrylcholinesterase II, More, non specific cholinesterase, non-specific cholinesterase, PChE, planarian cholinesterase, plasma cholinesterase, plasma esterase, plasmatic cholinesterase, PoBChE, propionylcholinesterase, pseudo choline esterase, pseudo cholinesterase, pseudocholinesterase, PTChI-ChE, rBChE, serum cholinesterase

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.1 Carboxylic-ester hydrolases
                3.1.1.8 cholinesterase

KM Value

KM Value on EC 3.1.1.8 - cholinesterase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
107
(+)-cocaine
-
pH 7.4, 25°C
0.0031 - 0.065
(-)-cocaine
0.023
(R)-3-benzoyloxy-1-benzylquinuclidinium bromide
-
24°C
0.127
(R)-3-benzoyloxy-1-methylquinuclidinium iodide
-
24°C
0.065
(S)-3-benzoyloxy-1-methylquinuclidinium iodide
-
24°C
0.12 - 1.9
2-Nitrophenyl butyrate
8.6
6-monoacetylmorphine
recombinant enzyme, pH 7.4, 37°C
0.29
acetoacetylcholine
-
-
0.25
acetyl-beta-methylthiocholine
-
in 0.1 M phosphate buffer, pH 7.5, at 30°C
0.027 - 0.148
Acetylcholine
0.08 - 0.14
acetylcholine iodide
0.019 - 4.8
acetylthiocholine
0.057 - 1.476
acetylthiocholine iodide
0.00301
BChE-FP
-
pH 7.0, 30°C
0.003 - 0.047
Benzoylcholine
0.00295 - 0.0592
benzoylthiocholine
1.22
beta-hydroxybutyrylcholine
-
-
0.021
butyryl thiocholine
-
pH 7, 22°C, native and intermediate state of the enzyme
0.0256
butyryl thiocholine iodide
-
pH 7, mutant with only 5 N-glycosylation sites
0.29 - 7.1
Butyrylcholine
0.000106 - 6
butyrylthiocholine
0.03 - 3.9
butyrylthiocholine iodide
0.042 - 0.434
cocaine
0.76
crotonylcholine
-
-
1.3 - 1.5
ethylbutyrate
0.12
heroin
recombinant enzyme, pH 7.4, 37°C
0.00008 - 0.002
N-methyl-(7-dimethylcarbamoxy)quinolinium iodide
0.066 - 0.162
N-methylindoxyl acetate
0.14
o-nitrophenylbutyrate
-
usual and atypical enzyme
0.01 - 0.02
phenylpropionate
0.02 - 0.04
phenylthioacetate
0.03
phenylthiobutyrate
-
ChE I and ChE II
0.017 - 5.4
propionylthiocholine
0.183
propionylthiocholine iodide
-
pH 7.4, 25°C
0.003 - 11
succinylthiocholine
0.05 - 0.5
valerylthiocholine
additional information
additional information
-