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3.1.1.8: cholinesterase

This is an abbreviated version!
For detailed information about cholinesterase, go to the full flat file.

Word Map on EC 3.1.1.8

Reaction

an acylcholine
+
H2O
=
choline
 +
a carboxylate

Synonyms

acyl choline acylhydrolase, acylcholine acyl-hydrolase, Acylcholine acylhydrolase, atypical cholinesterase, BChE, benzoylcholinesterase, BoBChE, BTCh, BTChI-ChE, BtChoEase, BuChE, butyrocholinesterase, butyryl-ChE, butyrylChE, butyrylcholine esterase, butyrylcholine-hydrolyzing enzyme, butyrylcholinesterase, butyrylcholinesterase K, calcium-activated butyrylcholinesterase, ChE, ChE-II, CholE, choline esterase, choline esterase II (unspecific), cholinesterase, dBChE, DjChE, Djche1, Djche2, EQ-BCHE, eqBChE, EqBuChE, esterase, butyrylcholine, esterase, choline, hBChE, HuBChE, mBuChE I, mBuChE II, monomeric butyrylcholinesterase I, monomeric butyrylcholinesterase II, More, non specific cholinesterase, non-specific cholinesterase, PChE, planarian cholinesterase, plasma cholinesterase, plasma esterase, plasmatic cholinesterase, PoBChE, propionylcholinesterase, pseudo choline esterase, pseudo cholinesterase, pseudocholinesterase, PTChI-ChE, rBChE, serum cholinesterase

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.1 Carboxylic-ester hydrolases
                3.1.1.8 cholinesterase

KI Value

KI Value on EC 3.1.1.8 - cholinesterase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0085
(+)-cocaine
-
pH 7.4, 25°C
0.009
(-)-cocaine
-
pH 7.4, 37°C
0.0286 - 0.0756
(-)-huperzine A
0.01102
(6R,7S)-6-(acetyloxy)-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl (2Z)-2-methylbut-2-enoate
pH 8.0, 22°C
0.01106
(6R,7S)-6-hydroxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl (2E)-2-methylbut-2-enoate
pH 8.0, 22°C
0.01751
(6R,7S)-6-hydroxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl 3-methylbut-2-enoate
pH 8.0, 22°C
0.00544
(6R,7S)-6-methoxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl 3-methylbut-2-enoate
pH 8.0, 22°C
0.02606
(6R,7S)-7-hydroxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-yl 4-methylpent-3-enoate
pH 8.0, 22°C
0.0008 - 0.12
(R,S)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride
0.0033
(S)-3-benzoyloxy-1-benzylquinuclidinium bromide
-
24°C
0.00023
1,2-dimethyl-beta-carbolin-2-ium iodide
-
pH and temperature not specified in the publication
0.00177
1,3-bis[5(diethyl-o-nitrobenzylammonium)pentyl]-6-methyluracil dibromide
pH and temperature not specified in the publication
0.0019 - 0.0093
1,5-bis(4-allyldimethylammoniumphenyl)pentan-3-one dibromide
0.00633
10-(2,2-dimethylpropanoyl)-10H-phenothiazine
-
pH 8.0, 23°C
0.00643
10-(2-ethylbutanoyl)-10H-phenothiazine
-
pH 8.0, 23°C
0.00359
10-(3,3-dimethylbutanoyl)-10H-phenothiazine
-
pH 8.0, 23°C
0.00646
10-(3-methylbutanoyl)-10H-phenothiazine
-
pH 8.0, 23°C
0.0109
10-(chloroacetyl)-10H-phenothiazine
-
pH 8.0, 23°C
0.0048
10-(cyclobutylcarbonyl)-10H-phenothiazine
-
pH 8.0, 23°C
0.00086
10-(cycloheptylcarbonyl)-10H-phenothiazine
-
pH 8.0, 23°C
0.00168
10-(cyclohexylacetyl)-10H-phenothiazine
-
pH 8.0, 23°C
0.00126
10-(cyclohexylcarbonyl)-10H-phenothiazine
-
pH 8.0, 23°C
0.00222
10-(cyclopentylacetyl)-10H-phenothiazine
-
pH 8.0, 23°C
0.00421
10-(cyclopentylcarbonyl)-10H-phenothiazine
-
pH 8.0, 23°C
0.0231
10-(cyclopropylcarbonyl)-10H-phenothiazine
-
pH 8.0, 23°C
0.0296
10-(methoxyacetyl)-10H-phenothiazine
-
pH 8.0, 23°C
0.0358
10-acetyl-10H-phenothiazine
-
pH 8.0, 23°C
0.0162
10-butyryl-10H-phenothiazine
-
pH 8.0, 23°C
0.00831
10-heptanoyl-10H-phenothiazine
-
pH 8.0, 23°C
0.00637
10-hexanoyl-10H-phenothiazine
-
pH 8.0, 23°C
0.0132
10-isobutyryl-10H-phenothiazine
-
pH 8.0, 23°C
0.0102
10-pentanoyl-10H-phenothiazine
-
pH 8.0, 23°C
0.0256
10-propionyl-10H-phenothiazine
-
pH 8.0, 23°C
0.34
2-((Z)-(hydroxyimino)methyl)-1-methylpyridinium chloride
-
pH 7.0, 25°C
0.0032
2-(1-piperidinyl)ethyl phenothiazine carbamate
-
23°C
0.00065
2-(1-pyrrolidinyl)ethyl phenothiazine carbamate
-
23°C
0.0024
2-(4-morpholino)ethyl phenothiazine carbamate
-
23°C
0.0006
2-(diethylamino)ethyl 10H-phenothiazine-10-carboxylate
-
23°C
0.0025
2-(dimethylamino)ethyl 10H-phenothiazine-10-carboxylate
-
23°C
0.0017
2-(trifluoromethyl)phenyl butylcarbamate
-
pH 7.0, 25°C, selectivity for EC 3.1.1.8 over EC 3.1.1.7 is 0.11
0.013
2-chlorophenyl butylcarbamate
-
pH 7.0, 25°C, selectivity for EC 3.1.1.8 over EC 3.1.1.7 is 0.6
0.000637
2-ethyl-1-methyl-beta-carbolin-2-ium iodide
-
pH and temperature not specified in the publication
0.0042
2-ethylphenyl butylcarbamate
-
pH 7.0, 25°C, selectivity for EC 3.1.1.8 over EC 3.1.1.7 is 0.4
0.017
2-methoxyphenyl butylcarbamate
-
pH 7.0, 25°C, selectivity for EC 3.1.1.8 over EC 3.1.1.7 is 2.5
0.011
2-methylphenyl butylcarbamate
-
pH 7.0, 25°C, selectivity for EC 3.1.1.8 over EC 3.1.1.7 is 1.1
0.0007
2-nitrophenyl butylcarbamate
-
pH 7.0, 25°C, selectivity for EC 3.1.1.8 over EC 3.1.1.7 is 0.04
0.022
2-tert-butoxyphenyl butylcarbamate
-
pH 7.0, 25°C, selectivity for EC 3.1.1.8 over EC 3.1.1.7 is 4
0.00074
3-(diethylamino)propyl 10H-phenothiazine-10-carboxylate
-
23°C
0.027
4-(aminocarbonyl)-1-(((2-((Z)-(hydroxyimino)methyl)pyridinium-1-yl)methoxy)methyl)pyridinium dichloride
-
pH 7.0, 25°C
0.273
4-carbamoyl-1-(3-(3-chloro-4-[(hydroxyimino)methyl]-pyridinium-1-yl)propyl)pyridinium
pH 7.4, 25°C
0.14
4-carbamoyl-1-(4-(3,5-dichloro-4-[(hydroxyimino)methyl]-pyridinium-1-yl)butyl)pyridinium
pH 7.4, 25°C
0.195
4-carbamoyl-1-(4-(3,5-dichloro-4-[(hydroxyimino)methyl]-pyridinium-1-yl)propyl)pyridinium
pH 7.4, 25°C
0.265
4-carbamoyl-1-(4-(3-chloro-4-[(hydroxyimino)methyl]-pyridinium-1-yl)butyl)pyridinium
pH 7.4, 25°C
0.187
4-carbamoyl-1-[(2E)-4-(3,5-dichloro-4-[(hydroxyimino)methyl]-pyridinium-1-yl)but-2-en-1-yl]pyridinium
pH 7.4, 25°C
0.294
4-carbamoyl-1-[(2E)-4-(3-chloro-4-[(hydroxyimino)methyl]-pyridinium-1-yl)but-2-en-1-yl]pyridinium
pH 7.4, 25°C
0.00064
7(R,S)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride
-
pH 8, 25°C
0.13502
7-O-galloyl-D-sedoheptulose
pH and temperature not specified in the publication
0.00226
abamectin
-
pH 7.5, 37°C
10
ambenonium
-
-
0.00011
amlodipine
-
-
0.00011
amlodipine besylate
-
-
0.0374
apigenin
-
0.215
asoxime
pH 7.4, 25°C
0.0032 - 0.007
Benzoylcholine
0.002
benzyl di-n-butyl phosphate
pH 7.5, 25°C
0.011
biphenyl-2-yl butylcarbamate
-
pH 7.0, 25°C, selectivity for EC 3.1.1.8 over EC 3.1.1.7 is 1.0
0.05
butyrylthiocholine
-
-
0.0003
Chlordiazepoxide
-
-
0.0003
chlordiazepoxide HCl
-
-
0.0322
chlorpromazine
-
pH 8.0, 23°C
11 - 15.89
choline
0.0032
cyclopentyl phenothiazine carbamate
-
23°C
38
cymserine
-
pH 7.0, 25°C
0.0008 - 0.0875
decamethonium
0.00192
decursidin
pH 8.0, 22°C
0.072
di-n-butyl 2-methylbenzyl phosphate
pH 7.5, 25°C
0.05
di-n-butyl 2-methylphenyl phosphate
pH 7.5, 25°C
0.0019
di-n-butyl 2-naphthyl phosphate
pH 7.5, 25°C
0.053
di-n-butyl 2-phenylethyl phosphate
pH 7.5, 25°C
0.011
di-n-butyl 3,4,5-trimethylphenyl phosphate
pH 7.5, 25°C
0.009
di-n-butyl 3,4-dimethylphenyl phosphate
pH 7.5, 25°C
0.001
di-n-butyl 3,5-dimethylphenyl phosphate
pH 7.5, 25°C
0.024
di-n-butyl 3-methylbenzyl phosphate
pH 7.5, 25°C
0.016
di-n-butyl 3-methylphenyl phosphate
pH 7.5, 25°C
0.014
di-n-butyl 4-methylbenzyl phosphate
pH 7.5, 25°C
0.008
di-n-butyl 4-methylphenyl phosphate
pH 7.5, 25°C
0.022
di-n-butyl naphthalen-1-yl phosphate
pH 7.5, 25°C
0.000043
diazepam
-
-
0.0185 - 0.0504
edrophonium
0.00000088 - 0.00000174
eserine
0.00005 - 0.0022
ethopropazine
0.0234
ethyl carbamate
-
23°C
0.0000071 - 0.000023
ethyl carbamoyl
0.09
fisetin
-
0.0069
galangin
-
0.09
Harmane
-
pH and temperature not specified in the publication
0.0019
hydralazine
-
-
0.0019
hydralazine HCl
-
-
0.000306
iprobenfos
-
pH 7.6, mean value of different animal muscle samples, overview
0.0181
iso-propyl carbamate
-
23°C
0.127
K074
-
-
0.338
K075
-
-
0.059
K114
-
-
0.043
kaempferol
-
0.06935
loganin
pH and temperature not specified in the publication
0.0011
lovastatin
-
-
0.166
luteolin
-
0.00028 - 0.00046
malachite green
0.00044
meldola blue
-
pH 8.0, 25°C
0.0102
methyl carbamate
-
23°C
0.00012 - 0.00041
methyl green
0.00111
methylene blue
-
pH 8.0, 25°C
0.001 - 0.0019
metoclopramide
-
competitive inhibition
0.09506
morroniside
pH and temperature not specified in the publication
0.071
myricetin
-
0.0134
n-butyl carbamate
-
23°C
0.0369
N-methylphenothiazine
-
pH 8.0, 23°C
0.0006
neostigmine
-
-
0.0012
nifedipine
-
-
0.00018
nile blue
-
pH 8.0, 25°C
0.00166
nile red
-
pH 8.0, 25°C
0.000028 - 0.123
paraoxon
0.0019 - 0.0045
pararosaniline
0.0000152 - 0.0000356
phenethyl cymserine
0.0318
phenothiazine
-
pH 8.0, 23°C
0.000655 - 0.0013
phenserine
0.009
phenyl butylcarbamate
-
pH 7.0, 25°C, selectivity for EC 3.1.1.8 over EC 3.1.1.7 is 0.8
0.39
pralidoxime
pH 7.4, 25°C
0.0004 - 0.0117
propidium
0.26
propyl phenothiazine carbamate
-
23°C
0.00046 - 0.000616
pyridostigmine bromide
0.068
quercetin
-
0.15
R-DEPP
pH 8.0, 25°C
0.5
rutin
-
0.007
S-DEPP
pH 8.0, 25°C
0.00075
simvastatin
-
-
0.0012 - 0.005
Succinylcholine
0.00000043 - 0.00001069
tacrine
0.0043
tert-butyl 10H-phenothiazine-10-carboxylate
-
23°C
0.00005 - 0.00006
tetra(monoisopropyl)diphosphortetramide
2 - 400
tetraethylammonium
4 - 600
Tetramethylammonium
0.0008
thioflavin T
pH and temperature not specified in the publication
0.000073 - 0.000139
tolserine
0.00009
tolserine N-dimethyl ammonium bromide
-
22°C
additional information
additional information
-