3.1.1.77: acyloxyacyl hydrolase

This is an abbreviated version!
For detailed information about acyloxyacyl hydrolase, go to the full flat file.

Word Map on EC 3.1.1.77

Reaction

3-(acyloxy)acyl group of bacterial toxin
+
H2O
=
3-hydroxyacyl group of bacterial toxin
+
a fatty acid

Synonyms

neutrophil acyloxyacyl hydrolase, AOAH, acyloxyacyl hydrolase

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.1 Carboxylic-ester hydrolases
                3.1.1.77 acyloxyacyl hydrolase

Reference

Reference on EC 3.1.1.77 - acyloxyacyl hydrolase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Erwin, A.L.; Munford, R.S.
Deacylation of structurally diverse lipopolysaccharides by human acyloxyacyl hydrolase
J. Biol. Chem.
265
16444-16449
1990
Homo sapiens
Manually annotated by BRENDA team
Hagen, F.S.; Grant, F.J.; Kuijper, J.L.; Slaughter, C.A.; Moomaw, C.R.; Orth, K.; O'Hara, P.J.; Munford, R.S.
Expression and characterization of recombinant human acyloxyacyl hydrolase, a leukocyte enzyme that deacylates bacterial lipopolysaccharides
Biochemistry
30
8415-8423
1991
Homo sapiens
Manually annotated by BRENDA team
Munford, R.S.; Hunter, J.P.
Acyloxyacyl hydrolase, a leukocyte enzyme that deacylates bacterial lipopolysaccharides, has phospholipase, lysophospholipase, diacylglycerollipase, and acyltransferase activities in vitro
J. Biol. Chem.
267
10116-10121
1992
Homo sapiens
Manually annotated by BRENDA team
Munford, R.S.; Hall, C.L.
Detoxification of bacterial lipopolysaccharides (endotoxins) by a human neutrophil enzyme
Science
234
203-205
1986
Homo sapiens
Manually annotated by BRENDA team
Munford, R.S.; Hall, C.L.
Purification of acyloxyacyl hydrolase, a leukocyte enzyme that removes secondary acyl chains from bacterial lipopolysaccharides
J. Biol. Chem.
264
15613-15619
1989
Homo sapiens
Manually annotated by BRENDA team
Mc Dermott, C.M.; Cullor, J.S.; Fenwick, B.W.
Intracellular and extracellular enzymatic deacylation of bacterial endotoxin during localized inflammation induced by Escherichia coli
Infect. Immun.
59
487-485
1991
Bos taurus, Homo sapiens
-
Manually annotated by BRENDA team
Munford, R.S.; Erwin, A.L.
Eukaryotic lipopolysaccharide deacylation enzyme
Methods Enzymol.
209
485-492
1992
Homo sapiens
Manually annotated by BRENDA team
Staab, J.F.; Ginkel, D.L.; Rosenberg, G.B.; Munford, R.S.
A saposin-like domain influences the intracellular localization, stability, and catalytic activity of human acyloxyacyl hydrolase
J. Biol. Chem.
269
23736-23742
1994
Homo sapiens
Manually annotated by BRENDA team
Cody, M.J.; Salkowski, C.A.; Henricson, B.E.; Detore, G.R.; Munford, R.S.; Vogel, S.N.
Effect of inflammatory and anti-inflammatory stimuli on acyloxyacyl hydrolase activity in murine macrophages
J. Endotoxin Res.
4
371-379
1997
Mus musculus
-
Manually annotated by BRENDA team
Staab, J.F.; Fosmire, S.; Zhang, M.; Varley, A.W.; Munford, R.S.
Distinctive structural features are shared by human, lapine, and murine acloxyacyl hydrolases
J. Endotoxin Res.
5
205-208
1999
Homo sapiens, Mus musculus, Oryctolagus cuniculus
-
Manually annotated by BRENDA team
feulner, J.A.; Lu, M.; Shelton, J.M.; Zhang, M.; Richardson, J.A.; Munford, R.S.
Identification of acyloxyacyl hydrolase, a lipopolysaccharide-detoxifying enzyme, in the murine urinary tract
Infect. Immun.
72
3171-3178
2004
Mus musculus (O35298), Mus musculus
Manually annotated by BRENDA team
Lu, M.; Zhang, M.; Kitchens, R.L.; Fosmire, S.; Takashima, A.; Munford, R.S.
Stimulus-dependent deacylation of bacterial lipopolysaccharide by dendritic cells
J. EXp. Med.
197
1745-1754
2003
Mus musculus
Manually annotated by BRENDA team
Barnes, K.C.; Grant, A.; Gao, P.; Baltadjieva, D.; Berg, T.; Chi, P.; Zhang, S.; Zambelli-Weiner, A.; Ehrlich, E.; Zardkoohi, O.; Brummet, M.E.; Stockton, M.; Watkins, T.; Gao, L.; Gittens, M.; Wills-Karp, M.; Cheadle, C.; Beck, L.A.; Beaty, T.H.; Becker, K.G.; garcia, J.G.N.; Mathias, R.A.
Polymorphisms in the novel gene acyloxyacyl hydroxylase (AOAH) are associated with asthma and associated phenotypes
J. Allergy Clin. Immunol.
118
70-77
2006
Homo sapiens (P28039)
Manually annotated by BRENDA team
Shao, B.; Lu, M.; Katz, S.C.; Varley, A.W.; Hardwick, J.; Rogers, T.E.; Ojogun, N.; Rockey, D.C.; Dematteo, R.P.; Munford, R.S.
A host lipase detoxifies bacterial lipopolysaccharides in the liver and spleen
J. Biol. Chem.
282
13726-13735
2007
Mus musculus (O35298)
Manually annotated by BRENDA team
Gioannini, T.L.; Teghanemt, A.; Zhang, D.; Prohinar, P.; Levis, E.N.; Munford, R.S.; Weiss, J.P.
Endotoxin-binding proteins modulate the susceptibility of bacterial endotoxin to deacylation by acyloxyacyl hydrolase
J. Biol. Chem.
282
7877-7884
2007
Homo sapiens
Manually annotated by BRENDA team
Mehrzad, J.; Dosogne, H.; De Spiegeleer, B.; Duchateau, L.; Burvenich, C.
Bovine blood neutrophil acyloxyacyl hydrolase (AOAH) activity during endotoxin and coliform mastitis
Vet. Res.
38
655-668
2007
Bos taurus (Q08DU1), Bos taurus
Manually annotated by BRENDA team
Lu, M.; Varley, A.W.; Ohta, S.; Hardwick, J.; Munford, R.S.
Host inactivation of bacterial lipopolysaccharide prevents prolonged tolerance following gram-negative bacterial infection
Cell host microbe
4
293-302
2008
Mus musculus (O35298)
Manually annotated by BRENDA team
Ojogun, N.; Kuang, T.Y.; Shao, B.; Greaves, D.R.; Munford, R.S.; Varley, A.W.
Overproduction of acyloxyacyl hydrolase by macrophages and dendritic cells prevents prolonged reactions to bacterial lipopolysaccharide in vivo
J. Infect. Dis.
200
1685-1693
2009
Mus musculus
Manually annotated by BRENDA team
Shao, B.; Kitchens, R.; Munford, R.; Rogers, T.; Rockey, D.; Varley, A.
Prolonged hepatomegaly in mice that cannot inactivate bacterial endotoxin
Hepatology
54
1051-1062
2011
Mus musculus
Manually annotated by BRENDA team
Klaffenbach, D.; Friedrich, D.; Strick, R.; Strissel, P.L.; Beckmann, M.W.; Rascher, W.; Gessner, A.; Doetsch, J.; Meissner, U.; Schnare, M.
Contribution of different placental cells to the expression and stimulation of antimicrobial proteins (AMPs)
Placenta
32
830-837
2011
Homo sapiens
Manually annotated by BRENDA team
Janelsins, B.M.; Lu, M.; Datta, S.K.
Altered inactivation of commensal LPS due to acyloxyacyl hydrolase deficiency in colonic dendritic cells impairs mucosal Th17 immunity
Proc. Natl. Acad. Sci. USA
111
373-378
2014
Mus musculus
Manually annotated by BRENDA team
Yang, W.; Yaggie, R.E.; Jiang, M.C.; Rudick, C.N.; Done, J.; Heckman, C.J.; Rosen, J.M.; Schaeffer, A.J.; Klumpp, D.J.
Acyloxyacyl hydrolase modulates pelvic pain severity
Am. J. Physiol. Regul. Integr. Comp. Physiol.
314
R353-R365
2018
Mus musculus (O35298), Mus musculus
Manually annotated by BRENDA team
Zou, B.; Jiang, W.; Han, H.; Li, J.; Mao, W.; Tang, Z.; Yang, Q.; Qian, G.; Qian, J.; Zeng, W.; Gu, J.; Chu, T.; Zhu, N.; Zhang, W.; Yan, D.; He, R.; Chu, Y.; Lu, M.
Acyloxyacyl hydrolase promotes the resolution of lipopolysaccharide-induced acute lung injury
PLoS Pathog.
13
e1006436
2017
Mus musculus (O35298), Mus musculus
Manually annotated by BRENDA team