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3.1.1.77: acyloxyacyl hydrolase

This is an abbreviated version!
For detailed information about acyloxyacyl hydrolase, go to the full flat file.

Word Map on EC 3.1.1.77

Reaction

3-(acyloxy)acyl group of bacterial toxin
+
H2O
=
3-hydroxyacyl group of bacterial toxin
+
a fatty acid

Synonyms

acyloxyacyl hydrolase, AOAH, neutrophil acyloxyacyl hydrolase

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.1 Carboxylic-ester hydrolases
                3.1.1.77 acyloxyacyl hydrolase

Reaction

Reaction on EC 3.1.1.77 - acyloxyacyl hydrolase

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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3-(acyloxy)acyl group of bacterial toxin + H2O = 3-hydroxyacyl group of bacterial toxin + a fatty acid
show the reaction diagram
The substrate is lipid A on the reducing end of the toxic lipopolysaccharide, LPS of Salmonella typhimurium and related organisms. It consists of diglucosamine, beta-D-GlcN-(1- 6)-D-GlcN, attached by glycosylation on O-6 of its non-reducing residue, phosphorylated on O-4 of this residue and on O-1 of ist potentially reducing residue. Both residues carry 3-(acyloxy)acyl groups on N-2 and O-3. The enzyme from human leucocytes detoxifies the lipid by hydrolysing the secondary acyl groups from O-3 of the 3-hydroxyacyl groups on the disaccharide, LPS. It also possesses a wide range of phospholipase and acyltransferase activities, e.g. EC 3.1.1.4, phospholipase A2, EC 3.1.1.5, lysophospholipase, EC 3.1.1.32, phospholipase A1 and EC 3.1.1.52, phosphatidylinositol deacylase, hydrolysing diacylglycerol and phosphatidyl compounds, but not triacylglycerols. It has a preference for saturated C12-C16 acyl groups
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