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3.1.1.77: acyloxyacyl hydrolase

This is an abbreviated version!
For detailed information about acyloxyacyl hydrolase, go to the full flat file.

Word Map on EC 3.1.1.77

Reaction

3-(acyloxy)acyl group of bacterial toxin
+
H2O
=
3-hydroxyacyl group of bacterial toxin
+
a fatty acid

Synonyms

acyloxyacyl hydrolase, AOAH, neutrophil acyloxyacyl hydrolase

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.1 Carboxylic-ester hydrolases
                3.1.1.77 acyloxyacyl hydrolase

Natural Substrates Products

Natural Substrates Products on EC 3.1.1.77 - acyloxyacyl hydrolase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
show the reaction diagram
3-(acyloxy)acyl group of bacterial toxin + H2O
3-hydroxyacyl group of bacterial toxin + a fatty acid
show the reaction diagram
host AOAH selectively removes the secondary fatty acyl chains from bacterial lipopolysaccharides, that are required for lipopolysaccharide recognition by its mammalian signaling receptor, MD-2-TLR4. Possibility that AOAH, by inactivating bacterial lipopolysaccharide within the liver and spleen, is an important endogenous control mechanism. Recombinant AOAH restores hepatic LPS deacylation and prevented LPS-induced hepatomegaly in Aoah-/- mice
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?
additional information
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