3.1.1.77: acyloxyacyl hydrolase
This is an abbreviated version!
For detailed information about acyloxyacyl hydrolase, go to the full flat file.
Word Map on EC 3.1.1.77
Reaction
Synonyms
acyloxyacyl hydrolase, AOAH, neutrophil acyloxyacyl hydrolase
ECTree
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Natural Substrates Products
Natural Substrates Products on EC 3.1.1.77 - acyloxyacyl hydrolase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
3-(acyloxy)acyl group of bacterial toxin + H2O
3-hydroxyacyl group of bacterial toxin + a fatty acid
host AOAH selectively removes the secondary fatty acyl chains from bacterial lipopolysaccharides, that are required for lipopolysaccharide recognition by its mammalian signaling receptor, MD-2-TLR4. Possibility that AOAH, by inactivating bacterial lipopolysaccharide within the liver and spleen, is an important endogenous control mechanism. Recombinant AOAH restores hepatic LPS deacylation and prevented LPS-induced hepatomegaly in Aoah-/- mice
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?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
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detoxification of LPS
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?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
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detoxification of LPS
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?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
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detoxification of LPS
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?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
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detoxification of LPS
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?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
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detoxification of LPS
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?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
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detoxification of LPS
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?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
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detoxification of LPS
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?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
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detoxification of LPS
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?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
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detoxification of LPS
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?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
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detoxification of LPS
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?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
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detoxification of LPS
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?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
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detoxification of LPS
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?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
deacylation greatly reduces the ability of lipopolysaccharide to stimulate cells via CD14-MD-2-Toll-like receptor 4. Cortical tubule cells may produce and secrete the enzyme to limit inflammatory responses to gram-negative bacteria throughout the urinary tract
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?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
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the major mammalian enzyme that deacylates the lipopolysaccharides contained in phygocytosed bacteria. The enzymatic deacylation of lipopolysaccharides is an intrinsic, regulated mechanism by which dendritic cells may modulate host response to this potent bacterial agonist
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?
3-(acyloxy)acyl group of bacterial toxin
3-hydroxyacyl group of bacterial toxin + a fatty acid
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detoxification of LPS
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?
additional information
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a decrease in neutrophil AOAH activity results in the appearance of lipopolysaccharide in the blood. Low blood neutrophil deacylation activity could be considered as a risk factor for severe clinical coliform mastitis
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?
additional information
?
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a decrease in neutrophil AOAH activity results in the appearance of lipopolysaccharide in the blood. Low blood neutrophil deacylation activity could be considered as a risk factor for severe clinical coliform mastitis
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?
additional information
?
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endotoxin-binding proteins modulate the susceptibility of bacterial endotoxin to deacylation by acyloxyacyl hydrolase
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?
additional information
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polymorphisms in markers within the acyloxyacyl hydroxylase gene are associated with the risk of asthma and associated quantitative traits (IgE and cytokine levels) among asthmatic subjects and their families in Barbados
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?
additional information
?
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the enzyme inactivates lipopolysaccharides deacylating secondary fatty acyl chains on the lipid A moiety of lipopolysaccharide
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?
