18.104.22.168: acyloxyacyl hydrolase
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neutrophil acyloxyacyl hydrolase, AOAH, acyloxyacyl hydrolase
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Engineering on EC 22.214.171.124 - acyloxyacyl hydrolase
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AOAH-deficient (Aoah-/-) mice, recovery from the tolerant state induced by Gram-negative bacteria is greatly delayed in mice that lack acyloxyacyl hydrolase (AOAH). Wild-type mice regain normal responsiveness within 14 days after they receive an intraperitoneal injection of LPS or Gram-negative bacteria, AOAH-deficient mice have greatly reduced proinflammatory responses to a second LPS injection for at least 3 weeks