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3.1.1.77: acyloxyacyl hydrolase

This is an abbreviated version!
For detailed information about acyloxyacyl hydrolase, go to the full flat file.

Word Map on EC 3.1.1.77

Reaction

3-(acyloxy)acyl group of bacterial toxin
+
H2O
=
3-hydroxyacyl group of bacterial toxin
+
a fatty acid

Synonyms

neutrophil acyloxyacyl hydrolase, AOAH, acyloxyacyl hydrolase

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.1 Carboxylic-ester hydrolases
                3.1.1.77 acyloxyacyl hydrolase

Engineering

Engineering on EC 3.1.1.77 - acyloxyacyl hydrolase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
AOAH-deficient (Aoah-/-) mice, recovery from the tolerant state induced by Gram-negative bacteria is greatly delayed in mice that lack acyloxyacyl hydrolase (AOAH). Wild-type mice regain normal responsiveness within 14 days after they receive an intraperitoneal injection of LPS or Gram-negative bacteria, AOAH-deficient mice have greatly reduced proinflammatory responses to a second LPS injection for at least 3 weeks