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3.1.1.77: acyloxyacyl hydrolase

This is an abbreviated version!
For detailed information about acyloxyacyl hydrolase, go to the full flat file.

Word Map on EC 3.1.1.77

Reaction

3-(acyloxy)acyl group of bacterial toxin
+
H2O
=
3-hydroxyacyl group of bacterial toxin
 +
a fatty acid

Synonyms

acyloxyacyl hydrolase, AOAH, neutrophil acyloxyacyl hydrolase

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.1 Carboxylic-ester hydrolases
                3.1.1.77 acyloxyacyl hydrolase

Disease

topprint

Disease on EC 3.1.1.77 - acyloxyacyl hydrolase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acute Lung Injury
Acyloxyacyl hydrolase promotes the resolution of lipopolysaccharide-induced acute lung injury.
acyloxyacyl hydrolase deficiency
Altered inactivation of commensal LPS due to acyloxyacyl hydrolase deficiency in colonic dendritic cells impairs mucosal Th17 immunity.
Asthma
LPS inactivation by a host lipase allows lung epithelial cell sensitization for allergic asthma.
Bacterial Infections
Lipopolysaccharide deacylation by an endogenous lipase controls innate antibody responses to Gram-negative bacteria.
Gram-Negative Bacterial Infections
Lipopolysaccharide deacylation by an endogenous lipase controls innate antibody responses to Gram-negative bacteria.
Gram-Positive Bacterial Infections
Deacylation of endotoxin during natural cases of bovine mastitis.
Hepatomegaly
Prolonged hepatomegaly in mice that cannot inactivate bacterial endotoxin.
Infections
Biochemical transformation of bacterial lipopolysaccharides by acyloxyacyl hydrolase reduces host injury and promotes recovery.
Deacylation of lipopolysaccharide in whole Escherichia coli during destruction by cellular and extracellular components of a rabbit peritoneal inflammatory exudate.
Mastitis
Bovine blood neutrophil acyloxyacyl hydrolase (AOAH) activity during endotoxin and coliform mastitis.
Deacylation of endotoxin during natural cases of bovine mastitis.
Reduction of acyloxyacyl hydrolase activity in circulating neutrophils from cows after parturition.
Placenta, Retained
Acyloxyacyl hydrolase activity of neutrophil leukocytes in normal early postpartum dairy cows and in cows with retained placenta.