3.1.1.63: 11-cis-retinyl-palmitate hydrolase

This is an abbreviated version!
For detailed information about 11-cis-retinyl-palmitate hydrolase, go to the full flat file.

Reaction

ECTree

3 Hydrolases

3.1 Acting on ester bonds

3.1.1 Carboxylic-ester hydrolases

3.1.1.63 11-cis-retinyl-palmitate hydrolase

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Results	in table
1	Activating Compound
1	CAS Registry Number
5	Inhibitors
1	Ki Value [mM]
4	KM Value [mM]
3	Localization
1	Natural Substrates/ Products (Substrates)
6	Organism
1	Pathway
2	pH Optimum
1	pH Range
1	Reaction
1	Reaction Type
6	Reference
8	Source Tissue
1	Storage Stability
10	Substrates and Products (Substrate)
1	Systematic Name
1	Temperature Stability [°C]

Inhibitors

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Inhibitors on EC 3.1.1.63 - 11-cis-retinyl-palmitate hydrolase

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all-trans-retinyl bromoacetate

Bos taurus

0.05 mM 50% inhibition

170640

all-trans-retinyl palmitate

Homo sapiens

weak inhibition

170637

NEM

Bos taurus

inhibits all-trans retinyl-palmitate hydrolase and 11-cis-retinyl-palmitate hydrolase activity of the liver enzyme, inhibits all-trans-retinyl-palmitate hydrolase activity of the pigment epithelium, 1-cis-retinyl-palmitate hydrolase activity of the pigment epithelium is unaffected

170660

triolein

Bos taurus

170660

additional information

Bos taurus

the distinctive apparent inhibition constants for NEM-induced inhibition of 11-cis retinyl-palmitate hydrolase and the all-trans-retinyl-palmitate hydrolase activity suggest a fundamental difference in the amino acid composition at the active site of the enzyme(s)

170660