3.1.1.43: alpha-amino-acid esterase

This is an abbreviated version!
For detailed information about alpha-amino-acid esterase, go to the full flat file.

Reaction

Synonyms

AEH, alpha-amino acid ester esterase, alpha-amino acid ester hydrolase, biphenyl hydrolase-like protein, BPH, esterase, alpha-amino acid, VACVase, valacyclovirase

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.1 Carboxylic-ester hydrolases

                3.1.1.43 alpha-amino-acid esterase

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Results	in table
1	Activating Compound
20	AA Sequence
24	Application
1	CAS Registry Number
12	Cloned(Commentary)
4	Crystallization (Commentary)
3	Disease/ Diagnostics
57	General Information
1	General Stability
15	Inhibitors
35	kcat/KM [mM/s]
76	KM Value [mM]
1	Localization
3	Metals/Ions
23	Molecular Weight [Da]
12	Natural Substrates/ Products (Substrates)
22	Organic Solvent Stability
63	Organism
36	PDB ID
27	pH Optimum
2	pH Range
2	pH Stability
9	pI Value
1	Posttranslational Modification
24	Protein Variants
12	Purification (Commentary)
2	Reaction
4	Reaction Type
59	Reference
10	Source Tissue
19	Specific Activity [micromol/min/mg]
266	Substrates and Products (Substrate)
34	Subunits
89	Synonyms
1	Systematic Name
23	Temperature Optimum [°C]
2	Temperature Range [°C]
3	Temperature Stability [°C]
54	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 3.1.1.43 - alpha-amino-acid esterase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

an alpha-aminoacid ester + H2O

an alpha-amino acid + an alcohol

6 entries

valacyclovir + H2O

?

Rattus norvegicus

-

stereospecific reaction

729021

-

-

?

valacyclovir + H2O

L-valine + acyclovir

Homo sapiens

-

-

693224

-

-

?

valganciclovir + H2O

L-valine + ganciclovir

Homo sapiens

-

-

693224

-

-

?

additional information

?

-

3 entries

an alpha-aminoacid ester + H2O

an alpha-amino acid + an alcohol

Acetobacter pasteurianus

-

-

649217

-

649217

r

an alpha-aminoacid ester + H2O

an alpha-amino acid + an alcohol

Acetobacter pasteurianus

-

-

652282

-

652282

r

an alpha-aminoacid ester + H2O

an alpha-amino acid + an alcohol

Acetobacter pasteurianus

-

-

652946

-

652946

r

an alpha-aminoacid ester + H2O

an alpha-amino acid + an alcohol

Acetobacter pasteurianus

Q8VRK8

-

649372

-

649372

r

an alpha-aminoacid ester + H2O

an alpha-amino acid + an alcohol

Bacillus mycoides

-

-

651785

-

651785

r

an alpha-aminoacid ester + H2O

an alpha-amino acid + an alcohol

Xanthomonas citri

-

-

652406

-

652406

r

additional information

?

-

Acidovorax avenae

-

alpha-amino acid ester hydrolase catalyzes the synthesis of beta-lactam antibiotics, e.g. cefadroxil, cefprozil and cefatrizine, containing an alpha-amino group with decreased activity toward antibiotics with a para-hydroxyl group

729461

-

-

?

additional information

?

-

Pseudomonas danceae

-

the enzyme synthesizes artificial cephalosporins by acylating the 7-amino group of cephalosporin nuclei with different alpha-amino acid esters

729021

-

-

?

additional information

?

-

Rattus norvegicus

-

substrate specificity of the enzyme, which hydrolyzes valacyclovir and some other aciclovir esters with an alpha-amino group in the acyl radical

729021

-

-

?