3.1.1.43: alpha-amino-acid esterase

This is an abbreviated version!
For detailed information about alpha-amino-acid esterase, go to the full flat file.

Word Map on EC 3.1.1.43

3.1.1.43

prodrugs

synthesis

acetobacter

turbidans

xanthomonas

ampicillin

valganciclovir

cephalexin

promoiety

beta-lactam

carrier-mediated

cocaine

citri

alpha/beta-hydrolase

acylases

drug development

Reaction

an alpha-amino acid ester

+

H2O

=

an alpha-amino acid

+

an alcohol

Synonyms

AEH, alpha-amino acid ester esterase, alpha-amino acid ester hydrolase, biphenyl hydrolase-like protein, BPH, esterase, alpha-amino acid, VACVase, valacyclovirase

ECTree

3.1 Acting on ester bonds

3.1.1 Carboxylic-ester hydrolases

3.1.1.43 alpha-amino-acid esterase

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Results	in table
1	Activating Compound
20	AA Sequence
24	Application
1	CAS Registry Number
12	Cloned(Commentary)
4	Crystallization (Commentary)
3	Disease/ Diagnostics
57	General Information
1	General Stability
15	Inhibitors
35	kcat/KM [mM/s]
76	KM Value [mM]
1	Localization
3	Metals/Ions
23	Molecular Weight [Da]
12	Natural Substrates/ Products (Substrates)
22	Organic Solvent Stability
63	Organism
36	PDB ID
27	pH Optimum
2	pH Range
2	pH Stability
9	pI Value
1	Posttranslational Modification
24	Protein Variants
12	Purification (Commentary)
2	Reaction
4	Reaction Type
59	Reference
10	Source Tissue
19	Specific Activity [micromol/min/mg]
266	Substrates and Products (Substrate)
34	Subunits
89	Synonyms
1	Systematic Name
23	Temperature Optimum [°C]
2	Temperature Range [°C]
3	Temperature Stability [°C]
54	Turnover Number [1/s]

KCat KM Value

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KCat KM Value on EC 3.1.1.43 - alpha-amino-acid esterase

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1580

4-carbamimidamidobenzyl L-isoleucinate

-

pH 7.4, 37°C

1660

4-carbamimidamidobenzyl L-phenylalaninate

-

pH 7.4, 37°C

3370

4-carbamimidamidobenzyl L-valinate

-

pH 7.4, 37°C

24

4-hydroxy-D-phenylglycine methyl ester

Acetobacter pasteurianus

-

pH 6.0, 30°C, recombinant enzyme

3.9

amoxicillin

Acetobacter pasteurianus

-

pH 6.0, 30°C, recombinant enzyme

30 - 162

ampicillin

show

1021

cefadroxil

Acetobacter pasteurianus

-

pH 6.0, 30°C, recombinant enzyme

6

cefaloglycin

Acetobacter pasteurianus

-

pH 6.0, 30°C, recombinant enzyme

95 - 1100

cephalexin

show

0.0018 - 0.0096

D-4-hydroxyphenylglycine methyl ester

show

3.3

D-phenylglycine amide

Acetobacter pasteurianus

-

above, pH 6.2, 27-30°C

148 - 1300

D-phenylglycine methyl ester

show

3980

phenylalanine benzyl ester

-

pH 7.4, 37°C, recombinant enzyme

14

phenylalanine ethyl ester

-

pH 7.4, 37°C, recombinant enzyme

44

phenylalanine methyl ester

-

pH 7.4, 37°C, recombinant enzyme

1660

phenylalanine [3-(hydroxymethyl)phenyl]guanidine

-

pH 7.4, 37°C, recombinant enzyme

213 - 850

valacyclovir

show

53

valganciclovir

-

pH 7.4, 37°C, recombinant enzyme

9490

valine 4-nitrobenzyl ester

-

pH 7.4, 37°C, recombinant enzyme

992

valine benzyl ester

-

pH 7.4, 37°C, recombinant enzyme

0.0013

valine [3-(aminomethyl)phenyl]guanidine

-

pH 7.4, 37°C, recombinant enzyme

3370

valine [3-(hydroxymethyl)phenyl]guanidine

-

pH 7.4, 37°C, recombinant enzyme

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Release 2023.1 (January 2023)