3.1.1.43: alpha-amino-acid esterase

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For detailed information about alpha-amino-acid esterase, go to the full flat file.

Word Map on EC 3.1.1.43

3.1.1.43

prodrugs

synthesis

acetobacter

turbidans

xanthomonas

ampicillin

valganciclovir

cephalexin

promoiety

beta-lactam

carrier-mediated

cocaine

citri

alpha/beta-hydrolase

acylases

drug development

Reaction

Synonyms

AEH, alpha-amino acid ester esterase, alpha-amino acid ester hydrolase, biphenyl hydrolase-like protein, BPH, esterase, alpha-amino acid, VACVase, valacyclovirase

ECTree

3 Hydrolases

3.1 Acting on ester bonds

3.1.1 Carboxylic-ester hydrolases

3.1.1.43 alpha-amino-acid esterase

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Results	in table
1	Activating Compound
20	AA Sequence
24	Application
1	CAS Registry Number
12	Cloned(Commentary)
4	Crystallization (Commentary)
3	Disease/ Diagnostics
57	General Information
1	General Stability
15	Inhibitors
35	kcat/KM [mM/s]
76	KM Value [mM]
1	Localization
3	Metals/Ions
23	Molecular Weight [Da]
12	Natural Substrates/ Products (Substrates)
22	Organic Solvent Stability
63	Organism
36	PDB ID
27	pH Optimum
2	pH Range
2	pH Stability
9	pI Value
1	Posttranslational Modification
24	Protein Variants
12	Purification (Commentary)
2	Reaction
4	Reaction Type
59	Reference
10	Source Tissue
19	Specific Activity [micromol/min/mg]
266	Substrates and Products (Substrate)
34	Subunits
89	Synonyms
1	Systematic Name
23	Temperature Optimum [°C]
2	Temperature Range [°C]
3	Temperature Stability [°C]
54	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 3.1.1.43 - alpha-amino-acid esterase

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7-amino-3-deacetoxycephalosporanic acid

Xanthomonas citri

hydrolysis of D-alpha-phenylglycine methyl ester

80935

Ag+

Stenotrophomonas maltophilia

A0A2Z6IAJ2

1 mM, complete inhibition

749442

ampicillin

Acetobacter pasteurianus

hydrolysis, substrate inhibition

80936

Ca2+

Stenotrophomonas maltophilia

A0A2Z6IAJ2

1 mM, 25% inhibition

749442

Cu2+

Stenotrophomonas maltophilia

1 mM, 25% inhibition

CuSO4

ethyl D-alpha-aminophenylacetate

Acetobacter pasteurianus

hydrolysis, substrate inhibition

80936

Fe2+

Stenotrophomonas maltophilia

1 mM, 30% inhibition

FeSO4

HgCl2

Li+

Stenotrophomonas maltophilia

A0A2Z6IAJ2

1 mM, 30% inhibition

749442

methyl D-alpha-aminophenylacetate

Acetobacter pasteurianus

hydrolysis, substrate inhibition

80936

p-nitrophenyl-p'-guanidino benzoate

Acetobacter pasteurianus

reversible inactivation

652282

phenylmethanesulfonyl fluoride

2 entries