3.1.1.31: 6-phosphogluconolactonase
This is an abbreviated version!
For detailed information about 6-phosphogluconolactonase, go to the full flat file.
Reaction
Synonyms
6-PGL, 6-phospho-D-glucose-delta-lactone hydrolase, 6-phosphoglucono-gamma-lactonase, 6-phosphogluconolactonase, 6-phosphogluconolactonase 3, 6-phosphonogluconolactonase, 6PGL, 6PGL-G6PDH, G6PD-6PGL, GL50803_8682, Glc6PD-6PGL, glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, glucose-6-phosphate dehydrognease-6-phosphogluconolactonase, GluPho, lactonase, phosphoglucono-, OG1RF_11582, PF14_0511, Pf6PGL, PGL, PGL1, PGL2, PGL3, PGL4, PGL5, PglA, phosphogluconolactonase, Xoo2316, YbhE protein
ECTree
3.1.1.31 6-phosphogluconolactonaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 3.1.1.31 - 6-phosphogluconolactonase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(S)-5-oxo-2-tetrahydrofurancarboxylic acid + H2O
L-alpha-hydroxyglutaric acid
-
-
-
-
?
6-phospho-D-glucono-1,4-lactone + H2O
6-phospho-D-gluconate
the gamma-lactone is more stable than the natural delta-lactone substrate. It contains a five-membered heterocyclic ring, whereas the delta-lactone contains a six-membered heterocyclic ring
-
-
?
6-phospho-D-glucono-1,4-lactone + H2O
6-phospho-D-gluconate
-
the gamma-lactone is more stable than the natural delta-lactone substrate. It contains a five-membered heterocyclic ring, whereas the delta-lactone contains a six-membered heterocyclic ring
-
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
6-phospho-D-gluconate
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
-
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
6-phosphogluconolactone
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
-
-
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
6-phospho-D-gluconate
-
ir
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
-
-
ir
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
6-phospho-D-gluconate
-
ir
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
-
-
ir
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
6-phosphogluconolactone
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
6-phosphogluconolactone
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
enzyme hydrolyzes both, the delta- and - gamma forms of 6-phosphogluconolactone
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
6-phospho-D-gluconate
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
second step in pentose phosphate pathway
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
-
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
-
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
second step in pentose phosphate pathway
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
second step in pentose phosphate pathway
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
6-phospho-D-gluconate
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
6-phospho-D-gluconate
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
6-phospho-D-gluconate
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
-
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
-
-
ir
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
6-phosphogluconolactone
-
ir
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
6-phospho-D-gluconate
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
6-phosphogluconolactone
-
ir
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
H165 is the catalytic residue, while R77 and R200 bind to the phosphate group. Ring opening of the lactone involves proton transfer from HE2 of H165 to O1 or O5 of the lactone, via a water molecule
-
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
6-phosphoglucono-delta-lactone is unstable and hydrolyzes spontaneously to the open-chain 6-phosphogluconate
-
?
6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
-
6-phosphoglucono-delta-lactone is unstable and hydrolyzes spontaneously to the open-chain 6-phosphogluconate
-
?
additional information
?
-
-
independence of glycolytic and pentose cycle intermediates in ad libitum fed rats
-
-
?
additional information
?
-
-
induction of 6-phosphogluconolactonase, phosphogluconate dehydrogenase and gluconokinase, enzymes of the oxidative pentose phosphate pathway by glucono-delta-lactone
-
-
?
additional information
?
-
-
induction of 6-phosphogluconolactonase, phosphogluconate dehydrogenase and gluconokinase, enzymes of the oxidative pentose phosphate pathway by glucono-delta-lactone
-
-
?
additional information
?
-
-
the enzyme is involved in the second step of the pentose phosphate pathway
-
-
?
