3.1.1.31: 6-phosphogluconolactonase

This is an abbreviated version!
For detailed information about 6-phosphogluconolactonase, go to the full flat file.

Reaction

6-phospho-D-glucono-1,5-lactone
+
H2O
=
6-phospho-D-gluconate

Synonyms

lactonase, phosphoglucono-, phosphogluconolactonase, 6-phosphoglucono-gamma-lactonase, 6-phospho-D-glucose-delta-lactone hydrolase, 6-PGL, PGL, 6PGL, glucose-6-phosphate dehydrognease-6-phosphogluconolactonase, G6PD-6PGL, Glc6PD-6PGL, 6-phosphogluconolactonase, 6-phosphonogluconolactonase, 6PGL-G6PDH, Pf6PGL, YbhE protein, glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, Xoo2316, PGL1, PGL2, PGL3, PGL4, PGL5, GluPho, PglA, 6-phosphogluconolactonase 3, PF14_0511, OG1RF_11582, GL50803_8682

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.1 Carboxylic-ester hydrolases
                3.1.1.31 6-phosphogluconolactonase

Reference

Reference on EC 3.1.1.31 - 6-phosphogluconolactonase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Cronin, C.N.; Nolan, D.P.; Voorheis, H.P.
The enzymes of the classical pentose phosphate pathway display differential activities in procyclic and bloodstream forms of Trypanosoma brucei
FEBS Lett.
244
26-30
1989
Trypanosoma brucei
Manually annotated by BRENDA team
Kawada, M.; Kawada, Y.; Takiguchi, H.; Shimazono, N.
Purification of 6-phosphogluconolactonase from rat liver and yeast; its separation from gluconolactonase
Biochim. Biophys. Acta
57
404-407
1962
Saccharomyces cerevisiae, Rattus norvegicus
Manually annotated by BRENDA team
Kupor, S.R.; Fraenkel, D.G.
6-Phosphogluconolactonase mutants of Escherichia coli and a maltose blue gene
J. Bacteriol.
100
1296-1301
1969
Escherichia coli, Escherichia coli K-10
Manually annotated by BRENDA team
Kupor, S.R.; Fraenkel, D.G.
Glucose metabolism in 6 phosphogluconolactonase mutants of Escherichia coli
J. Biol. Chem.
247
1904-1910
1972
Escherichia coli, Escherichia coli DF 2000, Escherichia coli K-10
Manually annotated by BRENDA team
Schofield, P.J.; Sols, A.
Rat liver 6-phosphogluconolactonase: a low Km enzyme
Biochem. Biophys. Res. Commun.
71
1313-1318
1976
Rattus norvegicus
Manually annotated by BRENDA team
Bauer, H.P.; Srihari, T.; Jochims, J.C.; Hofer, H.W.
6-Phosphogluconolactonase. Purification, properties and activities in various tissues
Eur. J. Biochem.
133
163-168
1983
Bos taurus, Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Scopes, R.K.
6-Phosphogluconolactonase from Zymomonas mobilis
FEBS Lett.
193
185-188
1985
Zymomonas mobilis, Zymomonas mobilis ATCC 31821
-
Manually annotated by BRENDA team
Casazza, J.P.; Veech, R.L.
The interdependence of glycolytic and pentose cycle intermediates in ad libitum fed rats
J. Biol. Chem.
261
690-698
1986
Rattus norvegicus
Manually annotated by BRENDA team
Beutler, E.; Kuhl, W.; Gelbart, T.
Blood cell phosphogluconolactonase: assay and properties
Br. J. Haematol.
62
577-586
1986
Homo sapiens
Manually annotated by BRENDA team
Hofer, H.W.; Bauer, H.P.
6-Phosphogluconolactonase
Cell Biochem. Funct.
5
97-99
1987
Bos taurus, Saccharomyces cerevisiae, Rattus norvegicus
Manually annotated by BRENDA team
Moir, R.D.; Stokes, G.B.
A spectrophotometric assay for 6-phosphogluconolactonase involving the use of immobilized enzymes to prepare the labile 6-phosphoglucono-delta-lactone substrate
Biochem. J.
256
69-73
1988
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Medina-Puerta, M.M.; Gallego-Iniesta, M.; Garrido-Pertierra, A.
Kinetic properties from bass liver 6-phosphogluconolactonase
Biochem. Int.
16
571-578
1988
Dicentrarchus labrax
Manually annotated by BRENDA team
Medina-Puerta, M.M.; Gallego-Iniesta, M.; Garrido-Pertierra, A.
Purification of 6-phosphogluconolactonase from bass (Dicentrarchus labrax L.) liver
Biochem. Int.
17
1011-1019
1988
Dicentrarchus labrax
Manually annotated by BRENDA team
Sinha, A.; Maitra, P.K.
Induction of specific enzymes of the oxidative pentose phosphate pathway by glucono-delta-lactone in Saccharomyces cerevisiae
J. Gen. Microbiol.
138
1865-1873
1992
Saccharomyces cerevisiae, Saccharomyces cerevisiae MC3
Manually annotated by BRENDA team
Rakitzis, E.T.; Papandreou, P.
Kinetic analysis of 6-phosphogluconolactone hydrolysis in hemolysates
Biochem. Mol. Biol. Int.
37
747-755
1995
Homo sapiens
Manually annotated by BRENDA team
Collard, F.; Collet, J.F.; Gerin, I.; Veiga-da-Cunha, M.; van Schaftingen, E.
Identification of the cDNA encoding human 6-phosphogluconolactonase, the enzyme catalyzing the second step of the pentose phosphate pathway(1)
FEBS Lett.
459
223-226
1999
Homo sapiens
Manually annotated by BRENDA team
Clarke, J.L.; Mason, P.J.
Murine hexose-6-phosphate dehydrogenase: a bifunctional enzyme with broad substrate specificity and 6-phosphogluconolactonase activity
Arch. Biochem. Biophys.
415
229-234
2003
Mus musculus
Manually annotated by BRENDA team
Clarke, J.L.; Scopes, D.A.; Sodeinde, O.; Mason, P.J.
Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase. A novel bifunctional enzyme in malaria parasites
Eur. J. Biochem.
268
2013-2019
2001
Homo sapiens, Plasmodium berghei
Manually annotated by BRENDA team
Hager, P.W.; Calfee, M.W.; Phibbs, P.V.
The Pseudomonas aeruginosa devB/SOL homolog, pgl, is a member of the hex regulon and encodes 6-phosphogluconolactonase
J. Bacteriol.
182
3934-3941
2000
Pseudomonas aeruginosa (Q9X2N2), Pseudomonas aeruginosa
Manually annotated by BRENDA team
Duffieux, F.; Van Roy, J.; Michels, P.A.; Opperdoes, F.R.
Molecular characterization of the first two enzymes of the pentose-phosphate pathway of Trypanosoma brucei. Glucose-6-phosphate dehydrogenase and 6-phosphogluconolactonase
J. Biol. Chem.
275
27559-27565
2000
Trypanosoma brucei (Q9GRG6), Trypanosoma brucei
Manually annotated by BRENDA team
Miclet, E.; Stoven, V.; Michels, P.A.M.; Opperdoes, F.R.; Lallemand, J.Y.; Duffieux, F.
NMR spectroscopic analysis of the first two steps of the pentose-phosphate pathway elucidates the role of 6-phosphogluconolactonase
J. Biol. Chem.
276
34840-34846
2001
Homo sapiens (O95336), Homo sapiens, Plasmodium falciparum (Q27741), Plasmodium falciparum, Trypanosoma brucei (Q9GRG6), Trypanosoma brucei
Manually annotated by BRENDA team
Clarke, J.L.; Sodeinde, O.; Mason, P.J.
A unique insertion in Plasmodium berghei glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase: evolutionary and functional studies
Mol. Biochem. Parasitol.
127
1-8
2003
Plasmodium berghei
Manually annotated by BRENDA team
Zimenkov, D.; Gulevich, A.; Skorokhodova, A.; Biriukova, I.; Kozlov, Y.; Mashko, S.
Escherichia coli ORF ybhE is pgl gene encoding 6-phosphogluconolactonase (EC 3.1.1.31) that has no homology with known 6PGLs from other organisms
FEMS Microbiol. Lett.
244
275-280
2005
Escherichia coli
Manually annotated by BRENDA team
Thomason, L.C.; Court, D.L.; Datta, A.R.; Khanna, R.; Rosner, J.L.
Identification of the Escherichia coli K-12 ybhE gene as pgl, encoding 6-phosphogluconolactonase
J. Bacteriol.
186
8248-8253
2004
Escherichia coli
Manually annotated by BRENDA team
Crooke, A.; Diez, A.; Mason, P.J.; Bautista, J.M.
Transient silencing of Plasmodium falciparum bifunctional glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase
FEBS J.
273
1537-1546
2006
Plasmodium falciparum
Manually annotated by BRENDA team
Delarue, M.; Duclert-Savatier, N.; Miclet, E.; Haouz, A.; Giganti, D.; Ouazzani, J.; Lopez, P.; Nilges, M.; Stoven, V.
Three dimensional structure and implications for the catalytic mechanism of 6-phosphogluconolactonase from Trypanosoma brucei
J. Mol. Biol.
366
868-881
2007
Trypanosoma brucei (Q385D6), Trypanosoma brucei
Manually annotated by BRENDA team
Hong, M.K.; Kim, J.K.; Kim, H.; Jung, J.; Ahn, Y.J.; Kim, J.G.; Lee, B.M.; Kang, L.W.
Expression, crystallization and preliminary X-ray crystallographic analysis of Xoo2316, a predicted 6-phosphogluconolactonase, from Xanthomonas oryzae pv. oryzae
Acta Crystallogr. Sect. F
64
1016-1018
2008
Xanthomonas oryzae
Manually annotated by BRENDA team
Tarighi, S.; Wei, Q.; Camara, M.; Williams, P.; Fletcher, M.P.; Kajander, T.; Cornelis, P.
The PA4204 gene encodes a periplasmic gluconolactonase (PpgL) which is important for fitness of Pseudomonas aeruginosa
Microbiology
154
2979-2990
2008
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Crimmins, G.T.; Schelle, M.W.; Herskovits, A.A.; Ni, P.P.; Kline, B.C.; Meyer-Morse, N.; Iavarone, A.T.; Portnoy, D.A.
Listeria monocytogenes 6-phosphogluconolactonase mutants induce increased activation of a host cytosolic surveillance pathway
Infect. Immun.
77
3014-3022
2009
Listeria monocytogenes
Manually annotated by BRENDA team
Duclert-Savatier, N.; Poggi, L.; Miclet, E.; Lopes, P.; Ouazzani, J.; Chevalier, N.; Nilges, M.; Delarue, M.; Stoven, V.
Insights into the enzymatic mechanism of 6-phosphogluconolactonase from Trypanosoma brucei using structural data and molecular dynamics simulation
J. Mol. Biol.
388
1009-1021
2009
Trypanosoma brucei
Manually annotated by BRENDA team
Xiong, Y.; DeFraia, C.; Williams, D.; Zhang, X.; Mou, Z.
Characterization of Arabidopsis 6-phosphogluconolactonase T-DNA insertion mutants reveals an essential role for the oxidative section of the plastidic pentose phosphate pathway in plant growth and development
Plant Cell Physiol.
50
1277-1291
2009
Arabidopsis thaliana (Q84WW2), Arabidopsis thaliana (Q8LEV7), Arabidopsis thaliana (Q8LG70), Arabidopsis thaliana (Q9FIN1), Arabidopsis thaliana (Q9LMX8)
Manually annotated by BRENDA team
Jortzik, E.; Mailu, B.M.; Preuss, J.; Fischer, M.; Bode, L.; Rahlfs, S.; Becker, K.
Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase: a unique bifunctional enzyme from Plasmodium falciparum
Biochem. J.
436
641-650
2011
Plasmodium falciparum, Homo sapiens (O95336), Homo sapiens
Manually annotated by BRENDA team
Hoelscher, C.; Meyer, T.; Von Schaewen, A.
Dual-targeting of Arabidopsis 6-phosphogluconolactonase 3 (PGL3) to chloroplasts and peroxisomes involves interaction with Trx m2 in the cytosol
Mol. Plant
7
252-255
2014
Arabidopsis thaliana
Manually annotated by BRENDA team
Calligari, P.A.; Salgado, G.F.; Pelupessy, P.; Lopes, P.; Ouazzani, J.; Bodenhausen, G.; Abergel, D.
Insights into internal dynamics of 6-phosphogluconolactonase from Trypanosoma brucei studied by nuclear magnetic resonance and molecular dynamics
Proteins
80
1196-1210
2012
Trypanosoma brucei
Manually annotated by BRENDA team
Allen, S.M.; Lim, E.E.; Jortzik, E.; Preuss, J.; Chua, H.H.; MacRae, J.I.; Rahlfs, S.; Haeussler, K.; Downton, M.T.; McConville, M.J.; Becker, K.; Ralph, S.A.
Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase is a potential drug target
FEBS J.
282
3808-3823
2015
Plasmodium falciparum (Q8IKU0), Plasmodium falciparum
Manually annotated by BRENDA team
Holt, J.; Kiedrowski, M.; Frank, K.; Du, J.; Guan, C.; Broderick, N.; Dunny, G.; Handelsman, J.
Enterococcus faecalis 6-phosphogluconolactonase is required for both commensal and pathogenic interactions with Manduca sexta
Infect. Immun.
83
396-404
2015
Enterococcus faecalis
Manually annotated by BRENDA team
Morales-Luna, L.; Serrano-Posada, H.; Gonzalez-Valdez, A.; Ortega-Cuellar, D.; Vanoye-Carlo, A.; Hernandez-Ochoa, B.; Sierra-Palacios, E.; Rufino-Gonzalez, Y.; Castillo-Rodriguez, R.A.; Perez de la Cruz, V.; Moreno-Vargas, L.; Prada-Gracia, D.; Marcial-Quino, J.; Gomez-Manzo, S.
Biochemical characterization and structural modeling of fused glucose-6-phosphate dehydrogenase-phosphogluconolactonase from Giardia lamblia
Int. J. Mol. Sci.
19
2518
2018
Giardia intestinalis (A8BWM5), Giardia intestinalis, Giardia intestinalis ATCC 50803 (A8BWM5)
Manually annotated by BRENDA team