3.1.1.31: 6-phosphogluconolactonase

This is an abbreviated version!
For detailed information about 6-phosphogluconolactonase, go to the full flat file.

Reaction

6-phospho-D-glucono-1,5-lactone
+
H2O
=
6-phospho-D-gluconate

Synonyms

lactonase, phosphoglucono-, phosphogluconolactonase, 6-phosphoglucono-gamma-lactonase, 6-phospho-D-glucose-delta-lactone hydrolase, 6-PGL, PGL, 6PGL, glucose-6-phosphate dehydrognease-6-phosphogluconolactonase, G6PD-6PGL, Glc6PD-6PGL, 6-phosphogluconolactonase, 6-phosphonogluconolactonase, 6PGL-G6PDH, Pf6PGL, YbhE protein, glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, Xoo2316, PGL1, PGL2, PGL3, PGL4, PGL5, GluPho, PglA, 6-phosphogluconolactonase 3, PF14_0511, OG1RF_11582, GL50803_8682

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.1 Carboxylic-ester hydrolases
                3.1.1.31 6-phosphogluconolactonase

General Information

General Information on EC 3.1.1.31 - 6-phosphogluconolactonase

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
malfunction
metabolism
additional information
-
analysis of effects of ligand binding on the internal dynamics of the enzyme by molecular dynamics simulations and nuclear magnetic resonance, alterations of conformational exchange, overview. Residues R77 and R200, located near the active site, interact directly with the phosphate group of 6-phospho-D-gluconate. Residue H165 is actively involved in catalysis