3.1.1.23: acylglycerol lipase
This is an abbreviated version!
For detailed information about acylglycerol lipase, go to the full flat file.
Word Map on EC 3.1.1.23
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3.1.1.23
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endocannabinoids
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cannabinoids
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2-arachidonoylglycerol
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amide
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anandamide
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agonist
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diacylglycerol
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pain
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arachidonic
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synaptic
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phospholipase
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2-arachidonoyl
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lipolytic
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adipose
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lipases
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prostaglandin
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triacylglycerols
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anxiety
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activity-based
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presynaptic
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rimonabant
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nociceptive
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analgesia
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antinociceptive
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cannabis
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cannabimimetic
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neuropathic
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n-arachidonoylethanolamine
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hormone-sensitive
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tetrahydrolipstatin
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4-nitrophenyl
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n-acylethanolamine
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fluorophosphonate
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diagnostics
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hyperalgesia
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allodynia
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endocannabinoid-mediated
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drug development
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nape-pld
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depolarization-induced
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medicine
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chlorpyrifos
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synthesis
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psychoactive
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delta9-tetrahydrocannabinol
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catalepsy
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pharmacology
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lysophospholipase
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2-monoacylglycerols
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marijuana
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oleoylethanolamide
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post-heparin
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anxiety-like
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palmitoylethanolamide
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anxiolytic
- 3.1.1.23
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endocannabinoids
- cannabinoids
- 2-arachidonoylglycerol
- amide
- anandamide
- agonist
- diacylglycerol
- pain
-
arachidonic
- synaptic
- phospholipase
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2-arachidonoyl
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lipolytic
- adipose
- lipases
- prostaglandin
- triacylglycerols
-
anxiety
-
activity-based
-
presynaptic
-
rimonabant
-
nociceptive
-
analgesia
-
antinociceptive
- cannabis
-
cannabimimetic
-
neuropathic
- n-arachidonoylethanolamine
-
hormone-sensitive
- tetrahydrolipstatin
- 4-nitrophenyl
- n-acylethanolamine
- fluorophosphonate
- diagnostics
- hyperalgesia
- allodynia
-
endocannabinoid-mediated
- drug development
- nape-pld
-
depolarization-induced
- medicine
- chlorpyrifos
- synthesis
-
psychoactive
- delta9-tetrahydrocannabinol
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catalepsy
- pharmacology
- lysophospholipase
- 2-monoacylglycerols
- marijuana
- oleoylethanolamide
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post-heparin
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anxiety-like
- palmitoylethanolamide
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anxiolytic
Reaction
Synonyms
AtMAGL, AtMAGL1, AtMAGL10, AtMAGL11, AtMAGL14, AtMAGL15, AtMAGL16, AtMAGL2, AtMAGL3, AtMAGL4, AtMAGL5, AtMAGL6, AtMAGL7, AtMAGL8, AtMAGL9, fatty acyl monoester lipase, glycerol-monoester acylhydrolase, HMGL, LH57_01015, lipase, lipase G, LipB, lipozyme IM, MAG hydrolase, MAG lipase, MAGL, MAGL-cy, MAGL-m, MAGL16, MAGL6, MAGL8, MGH, MGL, MGL Rv0183, MGL-like activity, MGLL, MGLP, monoacylglycerol hydrolase, monoacylglycerol lipase, monoglycerid lipase, monoglyceridase, monoglyceride hydrolase, monoglyceride lipase, monoglyceride lipase-like activity, monoglyceridyllipase, MSMEG_0220, mtbMGL, patatin-like protein 1, patatin-like protein 16, patatin-like protein 2, patatin-like protein 3, patatin-like protein 4, patatin-like protein 5, patatin-like protein 6, patatin-like protein 7, patatin-like protein 8, patatin-like protein 9, PLP1, PLP16, PLP2, PLP3, PLP4, PLP5, PLP6, PLP7, PLP8, PLP9, Rv0183, Rv0183 protein, Yju3p
ECTree
3.1.1.23 acylglycerol lipaseAdvanced search results
results (
results (KM Value
KM Value on EC 3.1.1.23 - acylglycerol lipase
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KM VALUE [mM] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.0098
7-hydroxycoumarinyl arachidonate
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at pH 8 and 25°C, in 10% dimethyl sulfoxide
1.25
arachidonoyl-1-thio-glycerol
in 10 mM Tris-HCl (pH 7.2), temperature not specified in the publication
0.0088
arachidonoyl-7-hydroxy-6-methoxy-4-methylcoumarin ester
recombinant enzyme, in TME buffer, at 37°C
0.25
lysophosphatidylcholine
pH 8.0, 30°C, AtMAGL4
0.01
2-(15-deoxy-DELTA12,14-prostaglandin J2)-glycerol
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mutant enzyme C242A, at pH 7.4 and 37°C
0.0122
2-(15-deoxy-DELTA12,14-prostaglandin J2)-glycerol
at pH 7.4 and 37°C
0.013
2-(15-deoxy-DELTA12,14-prostaglandin J2)-glycerol
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mutant enzyme C201A, at pH 7.4 and 37°C
0.015
2-(15-deoxy-DELTA12,14-prostaglandin J2)-glycerol
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wild type enzyme, at pH 7.4 and 37°C
0.016
2-(15-deoxy-DELTA12,14-prostaglandin J2)-glycerol
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mutant enzyme C208A, at pH 7.4 and 37°C
0.044
2-arachidonoylglycerol
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pH and temperature not specified in the publication
0.000014
2-oleoylglycerol
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in the presence of 0.0005 mM pristimerin, at pH 7.5, 37°C
0.000024
2-oleoylglycerol
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in the presence of 0.0003 mM pristimerin, at pH 7.5, 37°C
0.000027
2-oleoylglycerol
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in the presence of 0.0001 mM pristimerin, at pH 7.5, 37°C
0.000028
2-oleoylglycerol
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in the presence of vehicle (0.1% DMSO), at pH 7.5, 37°C
0.084
4-Methylumbelliferyl butyrate
mutant enzyme L167Q/L171Q, in 20 mM PIPES, pH 7.0, and 150 mM NaCl at 37°C
0.084
4-Methylumbelliferyl butyrate
mutant enzyme L167Q/L174Q, in 20 mM PIPES, pH 7.0, and 150 mM NaCl at 37°C
0.089
4-Methylumbelliferyl butyrate
mutant enzyme L171Q/L174Q, in 20 mM PIPES, pH 7.0, and 150 mM NaCl at 37°C
0.09
4-Methylumbelliferyl butyrate
mutant enzyme L169S/L176S/K160A, in 20 mM PIPES, pH 7.0, and 150 mM NaCl at 37°C
0.105
4-Methylumbelliferyl butyrate
mutant enzyme L171Q, in 20 mM PIPES, pH 7.0, and 150 mM NaCl at 37°C
0.11
4-Methylumbelliferyl butyrate
mutant enzyme L169S/L176S/K226A, in 20 mM PIPES, pH 7.0, and 150 mM NaCl at 37°C
0.123
4-Methylumbelliferyl butyrate
mutant enzyme L169S/L176S/K36A/K226A, in 20 mM PIPES, pH 7.0, and 150 mM NaCl at 37°C
0.124
4-Methylumbelliferyl butyrate
mutant enzyme L169S/L176S/K36A, in 20 mM PIPES, pH 7.0, and 150 mM NaCl at 37°C
0.136
4-Methylumbelliferyl butyrate
mutant enzyme L169S/L176S, in 20 mM PIPES, pH 7.0, and 150 mM NaCl at 37°C
0.137
4-Methylumbelliferyl butyrate
mutant enzyme L169S/L176S/K165A, in 20 mM PIPES, pH 7.0, and 150 mM NaCl at 37°C
0.162
4-Methylumbelliferyl butyrate
wild type enzyme, in 20 mM PIPES, pH 7.0, and 150 mM NaCl at 37°C
0.22
lysophosphatidylethanolamine
pH 8.0, 30°C, AtMAGL4
0.24
lysophosphatidylethanolamine
pH 8.0, 30°C, AtMAGL4
0.28
lysophosphatidylethanolamine
pH 8.0, 30°C, AtMAGL1
0.15
monoacylglycerol
pH 8.0, 30°C, AtMAGL8
0.16
monoacylglycerol
pH 8.0, 30°C, AtMAGL15
0.16
monoacylglycerol
pH 8.0, 30°C, AtMAGL6
0.17
monoacylglycerol
pH 8.0, 30°C, AtMAGL1
0.17
monoacylglycerol
pH 8.0, 30°C, AtMAGL10
0.17
monoacylglycerol
pH 8.0, 30°C, AtMAGL9
0.2 - 0.25
monoacylglycerol
pH 8.0, 30°C, AtMAGL2
0.2 - 0.25
monoacylglycerol
pH 8.0, 30°C, AtMAGL4
0.2 - 0.25
monoacylglycerol
pH 8.0, 30°C, AtMAGL7
0.3
monoacylglycerol
pH 8.0, 30°C, AtMAGL14
0.3
monoacylglycerol
pH 8.0, 30°C, AtMAGL16
additional information
additional information
Michaelis-Menten kinetics
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