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3.1.1.23: acylglycerol lipase

This is an abbreviated version!
For detailed information about acylglycerol lipase, go to the full flat file.

Word Map on EC 3.1.1.23

Reaction

CnHmCO-C3O3H7
+
H2O
=
CnHmCO2H
 +
glycerol

Synonyms

AtMAGL, AtMAGL1, AtMAGL10, AtMAGL11, AtMAGL14, AtMAGL15, AtMAGL16, AtMAGL2, AtMAGL3, AtMAGL4, AtMAGL5, AtMAGL6, AtMAGL7, AtMAGL8, AtMAGL9, fatty acyl monoester lipase, glycerol-monoester acylhydrolase, HMGL, LH57_01015, lipase, lipase G, LipB, lipozyme IM, MAG hydrolase, MAG lipase, MAGL, MAGL-cy, MAGL-m, MAGL16, MAGL6, MAGL8, MGH, MGL, MGL Rv0183, MGL-like activity, MGLL, MGLP, monoacylglycerol hydrolase, monoacylglycerol lipase, monoglycerid lipase, monoglyceridase, monoglyceride hydrolase, monoglyceride lipase, monoglyceride lipase-like activity, monoglyceridyllipase, MSMEG_0220, mtbMGL, patatin-like protein 1, patatin-like protein 16, patatin-like protein 2, patatin-like protein 3, patatin-like protein 4, patatin-like protein 5, patatin-like protein 6, patatin-like protein 7, patatin-like protein 8, patatin-like protein 9, PLP1, PLP16, PLP2, PLP3, PLP4, PLP5, PLP6, PLP7, PLP8, PLP9, Rv0183, Rv0183 protein, Yju3p

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.1 Carboxylic-ester hydrolases
                3.1.1.23 acylglycerol lipase

IC50 Value

IC50 Value on EC 3.1.1.23 - acylglycerol lipase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.1
(3R)-1-(3,4-dimethylphenyl)-5-oxo-N-[(4-oxo-3,4-dihydrophthalazin-1-yl)methyl]pyrrolidine-3-carboxamide
Homo sapiens
IC50 around 0.1 mM, pH and temperature not specified in the publication
0.000039
(3R)-N-(3,5-dimethylphenyl)-1-[2-(5-fluoro-1H-indol-3-yl)ethyl]-5-oxopyrrolidine-3-carboxamide
Homo sapiens
pH and temperature not specified in the publication
0.1
(3S)-N-(1,3-benzodioxol-4-ylmethyl)-1-[4-[(2-chlorobenzyl)oxy]phenyl]-5-oxopyrrolidine-3-carboxamide
Homo sapiens
IC50 around 0.1 mM, pH and temperature not specified in the publication
0.0117
(4-(4-chlorobenzoyl)piperidin-1-yl)(4-methoxyphenyl)-methanone
Homo sapiens
pH 7.2, temperature not specified in the publication
0.02
(5E)-5-(3-methylbutylidene)-2-thioxo-1,3-thiazolidin-4-one
Rattus norvegicus
-
recombinant purified enzyme, for 10 min at 37°C, in 50 mM Tris-HCl, pH 8.0, 0.5 mg/ml bovine serum albumin, fatty acid-free
0.00851
1-(hexa-5-enoyl)-(3S)-3-[1(R)-(4-phenylbutanoyloxy)-ethyl]-azetidin-2-one
Homo sapiens
-
at 37°C for 10 min, in 10 mM Tris-HCl buffer, 1 mM EDTA, 0.1% (w/v) bovine serum albumin, pH 8.0
0.0146
1-(hexa-5-enoyl)-(3S)-3-[1(R)-(biphenylacetyloxy)-ethyl]-azetidin-2-one
Homo sapiens
-
at 37°C for 10 min, in 10 mM Tris-HCl buffer, 1 mM EDTA, 0.1% (w/v) bovine serum albumin, pH 8.0
0.133
1-(pent-4-enoyl)-(3R,4R)-3-[1(R)-(pent-4-enoyloxy)-ethyl]-4-(acetoxy)-azetidin-2-one
Homo sapiens
-
at 37°C for 10 min, in 10 mM Tris-HCl buffer, 1 mM EDTA, 0.1% (w/v) bovine serum albumin, pH 8.0
0.00406
1-(pent-4-enoyl)-(3S)-3-[1(R)-(4-phenylbutanoyloxy)-ethyl]-azetidin-2-one
Homo sapiens
-
at 37°C for 10 min, in 10 mM Tris-HCl buffer, 1 mM EDTA, 0.1% (w/v) bovine serum albumin, pH 8.0
0.00184
1-(pent-4-enoyl)-(3S)-3-[1(R)-(biphenylacetyloxy)-ethyl]-azetidin-2-one
Homo sapiens
-
at 37°C for 10 min, in 10 mM Tris-HCl buffer, 1 mM EDTA, 0.1% (w/v) bovine serum albumin, pH 8.0
0.00472
1-(pent-4-enoyl)-(3S)-3-[1(R)-(hexa-5-enoyloxy)-ethyl]-azetidin-2-one
Homo sapiens
-
at 37°C for 10 min, in 10 mM Tris-HCl buffer, 1 mM EDTA, 0.1% (w/v) bovine serum albumin, pH 8.0
0.0233
1-(pent-4-enoyl)-(3S)-3-[1(R)-(pent-4-enoyloxy)-ethyl]-azetidin-2-one
Homo sapiens
-
at 37°C for 10 min, in 10 mM Tris-HCl buffer, 1 mM EDTA, 0.1% (w/v) bovine serum albumin, pH 8.0
0.0095 - 0.017
1-arachidonoylglycerol
0.0000008
1-methylethyl dodecylphosphonofluoridoate
Mus musculus
-
-
0.032
1-myristin
Rattus norvegicus
-
IC50 value for the membraneous and the cytosolic enzyme is 0.032 mM, complete inhibition is possible
0.2
12-deacetylsplendidin C
Homo sapiens
above, pH 7.2, temperature not specified in the publication
0.026
2,3-dihydroxypropyl (11Z)-icos-11-enoate
Rattus norvegicus
-
i.e. O-4066, IC50 value for the membraneous enzyme is 0.026 mM, for the cytosolic enzyme 0.019 mM, complete inhibition of the membraneous enzyme is possible, maximal inhibition of the cytosolic enzyme of 79%
0.016
2,3-dihydroxypropyl (11Z,14Z)-icosa-11,14-dienoate
Rattus norvegicus
-
i.e. O-3907, IC50 value for the membraneous enzyme is 0.016 mM, for the cytosolic enzyme 0.0051 mM, complete inhibition is possible
0.071
2,3-dihydroxypropyl (4Z,7Z,10Z,13Z)-17-ethylcycloheptadeca-4,7,10,13-tetraene-1-carboxylate
Rattus norvegicus
-
i.e. O-1428, IC50 value for the membraneous enzyme is 0.071 mM, for the cytosolic enzyme 0.015 mM, complete inhibition is possible
0.056
2,3-dihydroxypropyl (5Z)-icos-5-enoate
Rattus norvegicus
-
i.e. 3908, IC50 value for the membraneous enzyme is 0.056 mM, for the cytosolic enzyme 0.021 mM, complete inhibition of the membraneous enzyme is possible, maximal inhibition of the cytosolic enzyme of 65%
0.0083
2,3-dihydroxypropyl (5Z,8Z,11Z)-2-ethylcycloheptadeca-5,8,11-triene-1-carboxylate
Rattus norvegicus
-
i.e. O-3973, IC50 value for the membraneous enzyme is 0.0083 mM, for the cytosolic enzyme 0.0042 mM, complete inhibition is possible
0.017
2,3-dihydroxypropyl (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoate
Rattus norvegicus
-
i.e. O-3832, IC50 value for the membraneous enzyme is 0.017 mM, for the cytosolic enzyme 0.0082 mM, complete inhibition is possible
0.0051
2,3-dihydroxypropyl (6Z,9Z,12Z,15Z)-cyclohenicosa-6,9,12,15-tetraene-1-carboxylate
Rattus norvegicus
-
IC50 value for the membraneous enzyme is 0.0051 mM, for the cytosolic enzyme 0.0058 mM, complete inhibition is possible
0.011
2,3-dihydroxypropyl (7Z,10Z,13Z,16Z)-docosa-7,10,13,16-tetraenoate
Rattus norvegicus
-
IC50 value for the membraneous enzyme is 0.011 mM, for the cytosolic enzyme 0.0045 mM, complete inhibition is possible
0.073
2,3-dihydroxypropyl (8Z,11Z,14Z)-icosa-8,11,14-trienoate
Rattus norvegicus
-
i.e. 3846, IC50 value for the membraneous enzyme is 0.073 mM, for the cytosolic enzyme 0.0075 mM, complete inhibition is possible
0.1139
2-(4-hydroxyphenyl)ethyl alpha-L-rhamnopyranosyl-(1->3)-[alpha-L-rhamnopyranosyl-(1->6)]-2-O-acetyl-4-O-(4-coumaroyl)-beta-D-glucopyranoside
Homo sapiens
pH 7.4, temperature not specified in the publication
0.088
2-(4-hydroxyphenyl)ethyl alpha-L-rhamnopyranosyl-(1->3)-[alpha-L-rhamnopyranosyl-(1->6)]-2-O-acetyl-4-O-beta-D-glucopyranoside
Homo sapiens
pH 7.4, temperature not specified in the publication
0.1174
2-(4-hydroxyphenyl)ethyl alpha-L-rhamnopyranosyl-(1->3)-[alpha-L-rhamnopyranosyl-(1->6)]-beta-D-glucopyranoside
Homo sapiens
pH 7.4, temperature not specified in the publication
0.00000031
2-(nonylsulfanyl)-4H-1,3,2-benzodioxaphosphinine 2-oxide
Mus musculus
-
-
0.013
2-arachidonoylglycerol
Rattus norvegicus
-
inhibits the hydrolysis of cytosolic 2-oleoylglycerol, IC50 value is 0.013 mM, the affinity for the enzyme is highest with an arachidonyl side chain and decreases to fatty acids of shorter chain length
0.2
2-dehydroxysalvileucanthsin A
Homo sapiens
above, pH 7.2, temperature not specified in the publication
1
2-mercaptoethanol
Mortierella alliacea
-
in 50 mM phosphate buffer (pH 7.4), at 30°C
0.000239
2-methyl-4-isothiazolin-3-one
Rattus norvegicus
-
recombinant purified enzyme, for 10 min at 37°C, in 50 mM Tris-HCl, pH 8.0, 0.5 mg/ml bovine serum albumin, fatty acid-free
0.000151 - 0.000722
2-octyl-4-isothiazolin-3-one
0.000059
2-octyl-benzo[d]isothiazol-3-one
Rattus norvegicus
-
recombinant purified enzyme, for 10 min at 37°C, in 50 mM Tris-HCl, pH 8.0, 0.5 mg/ml bovine serum albumin, fatty acid-free
0.000043
2-oleoyl-4-isothiazolin-3-one
Rattus norvegicus
-
recombinant purified enzyme, for 10 min at 37°C, in 50 mM Tris-HCl, pH 8.0, 0.5 mg/ml bovine serum albumin, fatty acid-free
0.028
3-methoxy-N-phenyl-1,2,4-thiadiazol-5-amine
Rattus norvegicus
-
recombinant purified enzyme, for 10 min at 37°C, in 50 mM Tris-HCl, pH 8.0, 0.5 mg/ml bovine serum albumin, fatty acid-free
0.1
3-[(4S)-1-[2-(5-fluoro-1H-indol-3-yl)ethyl]-2,5-dioxoimidazolidin-4-yl]-N-[(1R,2R)-2-methylcyclohexyl]propanamide
Homo sapiens
IC50 above 0.1 mM, pH and temperature not specified in the publication
0.072
4-chlormercurybenzoate
Rattus norvegicus
IC50 value is 0.072 mM
0.00000007
4-cyanophenyl ethyl dodecylphosphonate
Mus musculus
-
-
0.00021 - 0.0037
4-nitrophenyl 4-[bis(1,3-benzodioxol-5-yl)hydroxymethyl]piperidine-1-carboxylate
0.00000028
4-nitrophenyl dodecyl(1-methylethyl)phosphinate
Mus musculus
-
-
0.0002
6-methyl-2-[(4-methylphenyl)amino]-4H-3,1-benzoxazin-4-one
Rattus norvegicus
-
MAGL expressed in HeLa cells
0.01 - 0.071
alpha-methyl-1-arachidonoyl glycerol
0.011
alpha-methyl-1-arachidonoylglycerol
Rattus norvegicus
-
IC50 value is 0.011 mM
0.0031
AM404
Homo sapiens
-
pH and temperature not specified in the publication
0.0000009 - 0.0000017
AM6701
0.0001 - 0.0028
AM6702
0.078
arachidonic acid
Rattus norvegicus
-
IC50 value is 0.078 mM
0.073
arachidonoyl serinol
Rattus norvegicus
-
IC50 value is 0.073 mM
0.00184
arachidonoyltrifluoromethylketone
Homo sapiens
-
-
0.012
benzol
Mus musculus
-
IC50 is 0.012 mM
0.000424
benzyl [4-(5-methoxy-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-2-methylphenyl]carbamate
Homo sapiens
pH and temperature not specified in the publication
0.0004 - 0.0005
CAY10499
0.0016
celastrol
Rattus norvegicus
-
purified MGL, at pH 7.5, 37°C
0.000034
chlorpyrifos oxon
0.0049
CP55,940
Homo sapiens
-
pH and temperature not specified in the publication
0.0000008
decyl benzodioxaphosphorin oxide
Mus musculus
-
IC50 is 0.80 nM
0.014
diazoxon
Mus musculus
-
IC50 is 0.014 mM
0.013
dichlorvos
Mus musculus
-
IC50 is 0.013 mM
0.00001
diethyl 3,5,6-trichloropyridin-2-yl phosphate
Mus musculus
-
-
0.0023
diethyl 4-nitrophenyl phosphate
Mus musculus
-
-
0.015
dihydrocelastrol
Rattus norvegicus
-
purified MGL, at pH 7.5, 37°C
0.015
dihydrocelastryl diacetate
Rattus norvegicus
-
purified MGL, at pH 7.5, 37°C
0.045
diisopropyl fluorophosphate
Mus musculus
-
i.e. DFP, n-C8H17P(O)(OCH3)F, IC50 is 0.045 mM
0.0008
Disulfiram
Homo sapiens
-
-
0.0002
dodecane-1-sulfonyl fluoride
Mus musculus
-
-
0.00000083
dodecyl benzodioxaphosphorin oxide
Mus musculus
-
IC50 is 0.83 nM
0.0002
dodecyl sulfonyl fluoride
Mus musculus
-
IC50 is 200 nM
1
EDTA
Mortierella alliacea
-
in 50 mM phosphate buffer (pH 7.4), at 30°C
0.00000014
ethyl 3,5,6-trichloropyridin-2-yl dodecylphosphonate
Mus musculus
-
-
0.000003
ethyl octylphosphonofluoridate
0.000315 - 0.000882
euphol
0.000045
heptyl benzodioxaphosphorin oxide
Mus musculus
-
IC50 is 45 nM
0.042
HgCl2
Rattus norvegicus
IC50 value is 0.042 mM
0.00000076
isopropyl dodecylfluorophosphate
Mus musculus
-
i.e. IDFP, n-C12H25P(O)(OCH3)F, IC50 is 0.76 nM
0.00000076
isopropyl dodecylfluorophosphonate
Rattus norvegicus
-
cytosolic MAGL
0.0468
jewenol A
Homo sapiens
pH 7.2, temperature not specified in the publication
0.0002177
JZL184
Homo sapiens
pH 7.4, 22°C
0.07
Maleimide
Rattus norvegicus
IC50 value is 0.070 mM
0.000076
methyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraen-1-ylphosphonofluoridate
Homo sapiens
-
-
0.0000054 - 0.00016
methyl arachidonyl fluorophosphonate
0.000002
methyl icosylphosphonofluoridoate
Mus musculus
-
-
0.000003
methyl octylphosphonofluoridate
0.068
N-(1-pyrenyl)-maleimide
Rattus norvegicus
IC50 value is 0.068 mM
0.021
N-(4-hydroxy-2-methylphenyl)arachidonylamide
Rattus norvegicus
-
i.e. VDM11, an anandamide uptake inhibitor, substrate of fatty acid amide hydrolase, EC 3.5.1.4, IC50 is 0.021 mM
0.02
N-(4-hydroxyphenyl)arachidonylamide
Rattus norvegicus
-
i.e. AM404, an anandamide uptake inhibitor, substrate of fatty acid amide hydrolase, EC 3.5.1.4, IC50 is 0.020 mM
0.00078
N-arachidonoyl dopamine
Homo sapiens
-
pH and temperature not specified in the publication
0.00014
N-arachidonoylmaleimide
Rattus norvegicus
IC50 value is 0.00014 mM
0.000155
N-arachidonyl maleimide
Homo sapiens
-
in 50 mM HEPES buffer, pH 8, 1 mM EDTA, and 10% dimethyl sulfoxide at 25°C for 60 min
0.0000091 - 6.64
N-arachidonylmaleimide
0.005 - 0.02
N-benzoylthiocarbamic cyclohexylethyl ester
0.051
N-cyclohexylmaleimide
Rattus norvegicus
IC50 value is 0.051 mM
0.0027 - 0.028
N-ethylmaleimide
0.413
N-hydroxymaleimide
Rattus norvegicus
IC50 value is 0.413 mM
0.00015
N-n-heptyl benzodioxaphosphorin oxide
Mus musculus
-
IC50 is 150 nM
0.044
N-Phenylmaleimide
Rattus norvegicus
IC50 value is 0.044 mM
0.053
N-propylmaleimide
Rattus norvegicus
IC50 value is 0.053 mM
0.1
N-[3-(4-fluorophenyl)-6-oxopyrazolo[5,1-c]pyrido[4,3-e][1,2,4]triazin-7(6H)-yl]-2-(naphthalen-2-yloxy)acetamide
Homo sapiens
IC50 above 0.1 mM, pH and temperature not specified in the publication
0.00001
N-[4-(1,3-benzothiazol-2-yl)phenyl]-2-(1H-benzotriazol-1-yl)acetamide
Homo sapiens
pH and temperature not specified in the publication
0.053
NEM
Rattus norvegicus
IC50 value is 0.053 mM
0.036
noladin ether
Rattus norvegicus
-
IC50 value is 0.036 mM
0.00015
O-n-octyl benzodioxaphosphorin oxide
Mus musculus
-
IC50 is 150 nM
0.00014
octane-1-sulfonyl fluoride
Mus musculus
-
-
0.00014
octyl sulfonyl fluoride
Mus musculus
-
IC50 is 140 nM
0.0023
paraoxon
Mus musculus
-
IC50 is 0.0023 mM
0.0023 - 0.0033
phenylmethylsulfonyl fluoride
0.000093 - 0.000398
pristimerin
0.004
pristimerol
Rattus norvegicus
-
purified MGL, at pH 7.5, 37°C
0.2
pseudorosmaricin
Homo sapiens
above, pH 7.2, temperature not specified in the publication
0.0000029
S-heptyl benzodioxaphosphorin oxide
Mus musculus
-
IC50 is 2.9 nM
0.31
S-nonyl benzodioxaphosphorin oxide
Mus musculus
-
IC50 is 0.31 nM
0.00000031
S-nonylbenzodioxaphosphorin oxide
Rattus norvegicus
-
cytosolic MAGL
0.0000031
S-pentyl benzodioxaphosphorin oxide
Mus musculus
-
IC50 is 3.1 nM
0.031
SPB 01403
Rattus norvegicus
-
-
0.000051
stearyl benzodioxaphosphorin oxide
Mus musculus
-
IC50 is 51 nM
0.00046
tetrahydrolipstatin
Homo sapiens
-
-
0.00041 - 0.0011
troglitazone
0.0031 - 0.0091
URB602
0.028 - 0.075
[1,1'-biphenyl]-3-yl-carbamic acid, cyclohexyl ester
0.00048 - 0.0011
[4-(5-methoxy-2-oxo-1,3,4-oxadiazol-3-yl)-2-methylphenyl]carbamic acid benzyl ester
0.0000002
[4-[bis(1,3-benzodioxol-5-yl)methyl]-1-piperidinyl](1H-1,2,4-triazol-1-yl)methanone
Homo sapiens
at pH 7.4 and 37°C
additional information
additional information
Homo sapiens
-
-
-