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1-naphthyl acetate + H2O
1-naphthol + acetate
1-naphthyl butyrate + H2O
1-naphthol + butyrate
-
-
-
-
?
1-phenylvinyl acetate + H2O
1-phenylethylenol + acetate
-
-
-
?
2,2,2-trifluoroethyl acetate + H2O
2,2,2-trifluoroethanol + acetate
-
-
-
?
2,2-difluoroethyl acetate + H2O
2,2-difluoroethanol + acetate
-
-
-
?
2,3-difluorophenyl acetate + H2O
2,3-difluorophenol + acetate
-
-
-
?
2,4-difluorophenyl acetate + H2O
2,4-difluorophenol + acetate
-
-
-
?
2,6-difluorophenyl acetate + H2O
2,6-difluorophenol + acetate
-
-
-
?
2-carboxythiophenyl acetate + H2O
2-carboxythiophenol + acetate
-
-
-
?
2-fluoroethyl acetate + H2O
2-fluoroethanol + acetate
-
-
-
?
2-fluorophenyl acetate + H2O
2-fluorophenol + acetate
-
-
-
?
2-methoxythiophenyl acetate + H2O
2-methoxythiophenol + acetate
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
2-naphthyl butanoate + H2O
2-naphthol + butanoate
-
-
-
?
2-naphthyl butyrate + H2O
2-naphthol + butyrate
-
-
-
-
?
2-nitrophenyl acetate + H2O
2-nitrophenol + acetate
3,4-dimethyl phenyl acetate + H2O
3,4-dimethylphenol + acetate
-
-
-
?
3-acetoxypyridine + H2O
?
-
-
?
3-cyanophenyl acetate + H2O
3-cyanophenol + acetate
-
-
-
?
3-fluorophenyl acetate + H2O
3-fluorophenol + acetate
-
-
-
?
3-naphthyl acetate + H2O
3-naphthol + acetate
-
-
-
?
3-naphthyl butanoate + H2O
3-naphthol + butanoate
-
-
-
?
3-nitrophenyl acetate + H2O
3-nitrophenol + acetate
-
-
-
?
4-(chloromethyl)phenyl acetate + H2O
4-chloromethyl phenol + acetate
-
-
-
?
4-acetoxyacetophenone + H2O
4-hydroxyacetophenone + acetate
-
-
-
?
4-acetoxybenzaldehyde + H2O
4-hydroxybenzaldehyde + acetate
-
-
-
?
4-acetoxybenzaldehyde + H2O
?
4-carboxyphenyl acetate + H2O
4-carboxyphenol + acetate
-
-
-
?
4-chlorophenyl acetate + H2O
4-chlorophenol + acetate
-
-
-
?
4-cyanophenyl acetate + H2O
4-cyanophenol + acetate
-
-
-
?
4-diethyl phosphate methyl benzoate + H2O
?
-
-
-
?
4-methoxy phenyl acetate + H2O
4-methoxy phenol + acetate
-
-
-
?
4-methylphenyl acetate + H2O
4-methylphenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
4-nitrophenyl butanoate + H2O
4-nitrophenol + butanoate
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
4-nitrophenyl caprate + H2O
4-nitrophenol + caprate
-
-
-
?
4-nitrophenyl caproate + H2O
4-nitrophenol + caproate
4-nitrophenyl caprylate + H2O
4-nitrophenol + caprylate
4-nitrophenyl decanoate + H2O
4-nitrophenol + decanoate
4-nitrophenyl diethylphosphate + H2O
diethylphosphate + 4-nitrophenol
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
4-nitrophenyl laurate + H2O
4-nitrophenol + laurate
4-nitrophenyl myristate + H2O
4-nitrophenol + myristate
about 10% of the activity with 4-nitrophenyl acetate
-
-
?
4-nitrophenyl octanoate + H2O
4-nitrophenol + octanoate
-
-
?
4-nitrophenyl palmitate + H2O
4-nitrophenol + palmitate
4-nitrophenyl pentanoate + H2O
4-nitrophenol + pentanoate
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
4-nitrophenyl valerate + H2O
4-nitrophenol + valerate
-
-
?
7-aminocephalosporanic acid + H2O
?
-
-
-
-
?
9-(2,4-dimethylphenoxycarbonyl)-10-methylacridinium triflate + H2O
2,4-dimethylphenol + 10-methylacridinium trifluoromethanesulfonate
-
-
-
-
?
9-(4-chlorophenoxycarbonyl)-10-methylacridinium triflate + H2O
4-chlorophenol + 10-methylacridinium trifluoromethanesulfonate
-
-
-
-
?
9-(4-chlorophenyloxycarbonyl)-10-methylacridinium triflate + H2O
9-carboxy-10-methylacridinium triflate + 4-chlorophenol
-
-
-
-
?
9-(4-methylphenoxycarbonyl)-10-methylacridinium triflate + H2O
4-methylphenol + 10-methylacridinium trifluoromethanesulfonate
-
-
-
-
?
9-(4-tert-butylphenoxycarbonyl)-10-methylacridinium triflate + H2O
4-tert-butylphenol + 10-methylacridinium trifluoromethanesulfonate
-
-
-
-
?
9-(phenyloxycarbonyl)-10-methylacridinium triflate + H2O
phenol + 10-methylacridinium trifluoromethanesulfonate
-
-
-
-
?
acetylcholine chloride + H2O
?
-
-
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
benzyl acetate + H2O
benzyl alcohol + acetate
-
-
-
?
beta-naphthyl acetate + H2O
beta-naphthol + acetate
-
-
-
-
?
bromoxynil octanoate + H2O
?
butyl acetate + H2O
butanol + acetate
-
-
-
?
butyrylcholine iodide + H2O
?
-
-
-
-
?
cephalosporin C + H2O
?
-
-
-
-
?
ethyl acetate + H2O
ethanol + acetate
-
-
-
?
ethyl hexanoate + H2O
ethanol + hexanoate
-
-
?
isopropyl acetate + H2O
isobutanol + acetate
-
-
-
?
ketoprofen ethyl ester + H2O
?
-
-
-
-
?
methyl 4-(acetyloxy)benzoate + H2O
methyl 4-hydroxybenzoate + acetate
-
-
-
?
mipafox + H2O
?
-
-
-
-
?
naphthalen-2-yl acetate + H2O
2-naphthol + acetate
-
-
-
?
p-nitrophenyl butyrate + H2O
p-nitrophenol + butanoate
-
-
-
-
?
p-nitrophenyl propionate + H2O
p-nitrophenol + propanoate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
phenyl valerate + H2O
phenol + valerate
-
-
-
-
?
phenylacetate + H2O
phenol + acetate
phenylthioacetate + H2O
thiophenol + acetate
propioncholine iodide + H2O
?
-
-
-
-
?
propyl acetate + H2O
propanol + acetate
-
-
-
?
S-(4-carboxyphenyl)-thioacetate + H2O
4-carboxythiophenol + acetate
-
-
-
?
S-methyl thiobutanoate + H2O
methanol + thiobutanoate
thiophenyl acetate + H2O
?
thiophenyl acetate + H2O
thiophenol + acetate
tributyrin + H2O
dibutyrin + butyrate
-
-
-
?
[(3-[(3-hydroxypropoxy)carbonyl]-5-[[3-([4-[(3-hydroxypropoxy)carbonyl]benzoyl]oxy)propoxy]carbonyl]phenyl)-lambda4-sulfanetriyl]tris(oxidanide) + H2O
terephthalic acid + 5-sulfoisophthalic acid + 1,3-propanediol
-
-
-
?
additional information
?
-
1-naphthyl acetate + H2O
1-naphthol + acetate
-
-
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
-
-
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
-
-
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
-
-
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
-
-
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
-
0.1% of the activity with phenyl acetate, A-type enzyme. 0.25% of the activity with phenyl acetate, B-type enzyme
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
-
0.1% of the activity with phenyl acetate
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
-
-
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
-
-
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
15.4% activity compared to 4-nitrophenyl acetate
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
5.5% of the activity with phenyl acetate, A-type enzyme. 7% of the activity with phenyl acetate, B-type enzyme
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
13.5% of the activity with phenyl acetate
-
-
?
2-naphthyl acetate + H2O
2-naphthol + acetate
-
-
-
-
?
2-nitrophenyl acetate + H2O
2-nitrophenol + acetate
-
-
-
-
?
2-nitrophenyl acetate + H2O
2-nitrophenol + acetate
-
2.1% of the activity with phenyl acetate, A-type enzyme. 2% of the activity with phenyl acetate, B-type enzyme
-
-
?
2-nitrophenyl acetate + H2O
2-nitrophenol + acetate
-
29% of the activity with phenyl acetate
-
-
?
4-acetoxybenzaldehyde + H2O
?
-
-
-
?
4-acetoxybenzaldehyde + H2O
?
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
inversely proportional relationship between the maximum specific growth rates of rhizobia strains and the activity of the entire alpha-esterase and beta-esterase pattern
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
inversely proportional relationship between the maximum specific growth rates of rhizobia strains and the activity of the entire alpha-esterase and beta-esterase pattern
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?, ir
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
2.5% of the activity with phenyl acetate, A-type enzyme. 3.5% of the activity with phenyl acetate, B-type enzyme
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
activity is 2.6fold higher than that with PON1 (P27169 (UniProt))
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
activity is about 40% of the activity with PON3 (Q15166 (UniProt))
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
activity is about 5% of that with PON1 (P27169 (UniProt))
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
inversely proportional relationship between the maximum specific growth rates of rhizobia strains and the activity of the entire alpha-esterase and beta-esterase pattern
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
31% of the activity with phenyl acetate
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
inversely proportional relationship between the maximum specific growth rates of rhizobia strains and the activity of the entire alpha-esterase and beta-esterase pattern
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
inversely proportional relationship between the maximum specific growth rates of rhizobia strains and the activity of the entire alpha-esterase and beta-esterase pattern
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
inversely proportional relationship between the maximum specific growth rates of rhizobia strains and the activity of the entire alpha-esterase and beta-esterase pattern
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
shows maximum activity (100%) against p-nitrophenyl acetate
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
highest catalytic efficiency (100% activity)
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
-
-
?
4-nitrophenyl butanoate + H2O
4-nitrophenol + butanoate
-
-
-
?
4-nitrophenyl butanoate + H2O
4-nitrophenol + butanoate
-
-
-
?
4-nitrophenyl butanoate + H2O
4-nitrophenol + butanoate
about 15% of the activity with 4-nitrophenyl acetate
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
highest specific activity
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
best substrate
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
best substrate
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
activity is similar to that with PON1 (P27169 (UniProt))
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
-
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
19.7% activity compared to 4-nitrophenyl acetate
-
-
?
4-nitrophenyl caproate + H2O
4-nitrophenol + caproate
-
-
?
4-nitrophenyl caproate + H2O
4-nitrophenol + caproate
-
-
-
?
4-nitrophenyl caproate + H2O
4-nitrophenol + caproate
-
-
-
?
4-nitrophenyl caproate + H2O
4-nitrophenol + caproate
4.1% activity compared to 4-nitrophenyl acetate
-
-
?
4-nitrophenyl caprylate + H2O
4-nitrophenol + caprylate
-
10% activity compared to 4-nitrophenyl butyrate
-
-
?
4-nitrophenyl caprylate + H2O
4-nitrophenol + caprylate
-
-
-
-
?
4-nitrophenyl caprylate + H2O
4-nitrophenol + caprylate
about 10% of the activity with 4-nitrophenyl acetate
-
-
?
4-nitrophenyl caprylate + H2O
4-nitrophenol + caprylate
-
-
?
4-nitrophenyl caprylate + H2O
4-nitrophenol + caprylate
-
-
-
?
4-nitrophenyl decanoate + H2O
4-nitrophenol + decanoate
-
-
?
4-nitrophenyl decanoate + H2O
4-nitrophenol + decanoate
-
low activity
-
-
?
4-nitrophenyl diethylphosphate + H2O
diethylphosphate + 4-nitrophenol
-
-
-
?
4-nitrophenyl diethylphosphate + H2O
diethylphosphate + 4-nitrophenol
-
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
-
-
-
-
?
4-nitrophenyl hexanoate + H2O
4-nitrophenol + hexanoate
-
-
?
4-nitrophenyl laurate + H2O
4-nitrophenol + laurate
-
-
-
-
?
4-nitrophenyl laurate + H2O
4-nitrophenol + laurate
about 10% of the activity with 4-nitrophenyl acetate
-
-
?
4-nitrophenyl laurate + H2O
4-nitrophenol + laurate
-
-
-
?
4-nitrophenyl palmitate + H2O
4-nitrophenol + palmitate
about 5% of the activity with 4-nitrophenyl acetate
-
-
?
4-nitrophenyl palmitate + H2O
4-nitrophenol + palmitate
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
-
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
activity is 1.5fold higher than that with PON1 (P27169 (UniProt))
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
activity is 8.7fold higher than that with PON1 (P27169 (UniProt))
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
activity is about 10% of the activity with PON3 (Q15166 (UniProt))
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
activity is about 65% of the activity with PON3 (Q15166 (UniProt))
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
activity is about 7% of that with PON1 (P27169 (UniProt))
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
-
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
-
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
-
-
?
binapacryl + H2O
?
-
-
-
?
binapacryl + H2O
?
-
-
-
?
binapacryl + H2O
?
-
-
-
?
bromoxynil octanoate + H2O
?
-
-
-
?
bromoxynil octanoate + H2O
?
-
-
-
?
bromoxynil octanoate + H2O
?
-
-
-
?
diclofop methyl + H2O
?
-
-
-
?
diclofop methyl + H2O
?
-
-
-
?
diclofop methyl + H2O
?
-
-
-
?
phenyl acetate + H2O
?
-
-
-
-
?
phenyl acetate + H2O
?
-
-
-
-
?
phenyl acetate + H2O
?
-
-
-
-
?
phenyl acetate + H2O
?
-
-
-
-
?
phenyl acetate + H2O
?
-
-
-
-
?
phenyl acetate + H2O
?
-
-
-
-
?
phenyl acetate + H2O
?
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
ir
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
652704, 665028, 692695, 693321, 702421, 703470, 707155, 707214, 708095, 709261, 709755, 714112, 714759, 714893, 714895, 715735, 715738, 729339, 749628, 749762, 749840, 750340, 750345, 750428, 750482, 750483, 750484, 750511, 750758, 752150, 752173 -
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
activity is less than 1% of that with PON1 (P27169 (UniProt))
-
-
?
phenyl acetate + H2O
phenol + acetate
activity is more than 100fold higher than with PON2 (Q15165 (UniProt)) and PON3 (Q15166 (UniProt))
-
-
?
phenyl acetate + H2O
phenol + acetate
arylesterase activity is independent of the polymorphic form of PON1
-
-
?
phenyl acetate + H2O
phenol + acetate
arylesterase activity of PON1
-
-
?
phenyl acetate + H2O
phenol + acetate
enzyme protein also shows activities of EC 3.1.8.1 and EC 3.1.1.25
-
-
?
phenyl acetate + H2O
phenol + acetate
-
human serum paraoxonase/arylesterase is an esterase with broad substrate specificity. It occurs in two genetically determined allozymic forms, designated types A and B. These allozymes are the products of two allelic genes located at the paraoxonase locus on chromosome 7, which is closely linked to the gene for cystic fibrosis. Paraoxonase activity of the B type isozyme is considerably higher and stimulated more by 1 M NaCl than A-type paraoxonase. The ratio of paraoxonase activity to arylesterase activity of the B-isozyme is about 8, and that of the A isozyme about 1
-
-
?
phenyl acetate + H2O
phenol + acetate
lowest activity with phenyl acetate
-
-
?
phenyl acetate + H2O
phenol + acetate
-
PON1 activity determined towards the synthetic compounds paraoxon and phenyl acetate reflects no association with markers of oxidative stress
-
-
?
phenyl acetate + H2O
phenol + acetate
PON1 activity determined towards the synthetic compounds paraoxon and phenyl acetate reflects no association with markers of oxidative stress
-
-
?
phenyl acetate + H2O
phenol + acetate
shows highest hydrolytic rate towards phenyl acetate
-
-
?
phenyl acetate + H2O
phenol + acetate
-
the enzyme exists in two genetically determined allozymic forms, and these A and B allozymes possess both paraoxonase and arylesterase activities. B-type esterase has relatively higher paraoxonase activity and is stimulated to a greater degree by 1 M NaCl than the A allozyme
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
?
phenyl acetate + H2O
phenol + acetate
best substrate
-
?
phenyl acetate + H2O
phenol + acetate
best substrate
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
?
phenyl acetate + H2O
phenol + acetate
-
-
-
-
?
phenyl acetate + H2O
phenol + acetate
166% activity compared to 4-nitrophenyl acetate
-
-
?
phenylacetate + H2O
phenol + acetate
-
-
-
-
?
phenylacetate + H2O
phenol + acetate
-
-
-
?
phenylacetate + H2O
phenol + acetate
-
-
-
-
?
phenylacetate + H2O
phenol + acetate
-
-
-
?
phenylacetate + H2O
phenol + acetate
-
-
-
-
?
phenylthioacetate + H2O
thiophenol + acetate
-
-
?
phenylthioacetate + H2O
thiophenol + acetate
-
-
?
phenylthioacetate + H2O
thiophenol + acetate
-
-
?
S-methyl thiobutanoate + H2O
methanol + thiobutanoate
-
-
-
-
?
S-methyl thiobutanoate + H2O
methanol + thiobutanoate
-
-
-
?
thiophenyl acetate + H2O
?
-
27% of the activity with phenyl acetate, A-type enzyme. 34% of the activity with phenyl acetate, B-type enzyme
-
-
?
thiophenyl acetate + H2O
?
-
30.5% of the activity with phenyl acetate
-
-
?
thiophenyl acetate + H2O
thiophenol + acetate
-
-
-
-
?
thiophenyl acetate + H2O
thiophenol + acetate
-
-
-
?
additional information
?
-
-
no activity with 4-nitrophenyl laurate and 4-nitrophenyl palmitate
-
-
?
additional information
?
-
-
the enzyme is a carboxylesterase and has highest activity with 4-nitrophenyl butyrate, activity decreases with acylglycerols containing longer carbon chains
-
-
?
additional information
?
-
substrate specificity of this arylesterase is higher toward short chain pnitrophenyl esters (C2 to C4) and also toward aromatic esters, such as phenyl acetate. enzyme is a serine esterase, the catalytic triad is composed of residues Ser163, Asp263, and His293 in the active site
-
-
?
additional information
?
-
substrate specificity of this arylesterase is higher toward short chain pnitrophenyl esters (C2 to C4) and also toward aromatic esters, such as phenyl acetate. enzyme is a serine esterase, the catalytic triad is composed of residues Ser163, Asp263, and His293 in the active site
-
-
?
additional information
?
-
-
the enzyme is one of the HDL-associated antioxidant proteins, overview
-
-
?
additional information
?
-
-
paraoxonase-1 is an enzyme with three activities which are inversely related to cardiovascular diseases, paraoxonase and arylesterase activities are involved in coronary artery disease, overview
-
-
?
additional information
?
-
-
polymorphisms allele frequency in relation to exposure of individuals to organophosphates, overview
-
-
?
additional information
?
-
polymorphisms allele frequency in relation to exposure of individuals to organophosphates, overview
-
-
?
additional information
?
-
PON1 hydrolyses esters, including organophosphates and lactones, and exhibits anti-atherogenic properties, the enzyme is associated to high-density-lipoprotein, bound together with the human phosphate binding protein
-
-
?
additional information
?
-
-
PON1 hydrolyses esters, including organophosphates and lactones, and exhibits anti-atherogenic properties, the enzyme is associated to high-density-lipoprotein, bound together with the human phosphate binding protein
-
-
?
additional information
?
-
-
the enzyme is important in the mechanism of organophosphorous toxicity
-
-
?
additional information
?
-
the enzyme is important in the mechanism of organophosphorous toxicity
-
-
?
additional information
?
-
PON1 hydrolyzes organophosphates, such as paraoxon, aromatic esters, for instance, phenyl acetate, and also lipid peroxidation products, and reduces the accumulation of them, PON1 prevents the acceleration of atherosclerosis, exhibits antioxidant ability, and assumes an antiatherogenic property. Negative correlation between the activity of PON1 and the level of lipid hydroperoxides in the rheumatoid arthritis patient group, overview
-
-
?
additional information
?
-
-
PON1 hydrolyzes organophosphates, such as paraoxon, aromatic esters, for instance, phenyl acetate, and also lipid peroxidation products, and reduces the accumulation of them, PON1 prevents the acceleration of atherosclerosis, exhibits antioxidant ability, and assumes an antiatherogenic property. Negative correlation between the activity of PON1 and the level of lipid hydroperoxides in the rheumatoid arthritis patient group, overview
-
-
?
additional information
?
-
PON1 is not able to prevent macrophage oxidative stress, however, is able to retard macrophage-induced low-density lipoprotein oxidation
-
-
?
additional information
?
-
-
PON1 is not able to prevent macrophage oxidative stress, however, is able to retard macrophage-induced low-density lipoprotein oxidation
-
-
?
additional information
?
-
PON1 plays a key role in the protection of low density lipoproteins and high density lipoproteins from oxidation by hydrolyzing activated phospholipids and lipid peroxide products
-
-
?
additional information
?
-
-
PON1 plays a key role in the protection of low density lipoproteins and high density lipoproteins from oxidation by hydrolyzing activated phospholipids and lipid peroxide products
-
-
?
additional information
?
-
the active site of the enzyme is characterized by two distinct binding regions, the hydrophobic binding site for arylesters/lactones and the paraoxon binding site for phosphotriesters
-
-
?
additional information
?
-
-
the active site of the enzyme is characterized by two distinct binding regions, the hydrophobic binding site for arylesters/lactones and the paraoxon binding site for phosphotriesters
-
-
?
additional information
?
-
the enzyme is located on high-density lipoprotein and prevents low-density-lipoprotein and high-density-lipoprotein oxidation both in vivo and in vitro through hydrolysis of lipid peroxides, the risk of ischemic stroke is related to the genotype of PON1 192RQ polymorphisms, overview
-
-
?
additional information
?
-
-
the enzyme is located on high-density lipoprotein and prevents low-density-lipoprotein and high-density-lipoprotein oxidation both in vivo and in vitro through hydrolysis of lipid peroxides, the risk of ischemic stroke is related to the genotype of PON1 192RQ polymorphisms, overview
-
-
?
additional information
?
-
does not hydrolyse demeton-S-methyl
-
-
?
additional information
?
-
-
does not hydrolyse demeton-S-methyl
-
-
?
additional information
?
-
exhibits diazoxonase, paraoxonase, and arylesterase activities
-
-
?
additional information
?
-
paraoxonase 1 enzyme with three activities, which are paraoxonase, arylesterase and diazoxonase
-
-
?
additional information
?
-
-
paraoxonase 1 enzyme with three activities, which are paraoxonase, arylesterase and diazoxonase
-
-
?
additional information
?
-
-
PON1 catalyses the hydrolysis of arylesters, toxic organophosphate compounds, carbamates and lactones, shows higher arylesterase than paraoxonase activity
-
-
?
additional information
?
-
PON1 contains paraoxonase and arylesterase activities
-
-
?
additional information
?
-
-
PON1 contains paraoxonase and arylesterase activities
-
-
?
additional information
?
-
PON1 hydrolyzes organophosphates, arylesters and lactones, whereas the lactones activity is assumed as the physio/pathological one
-
-
?
additional information
?
-
PON1 is an high density lipoprotein-associated enzyme with three activities: paraoxonase, arylesterase and dyazoxonase
-
-
?
additional information
?
-
-
PON1 is an high density lipoprotein-associated enzyme with three activities: paraoxonase, arylesterase and dyazoxonase
-
-
?
additional information
?
-
rhPON3 can effectively delay and inhibit oxidation of high density lipoprotein in vitro
-
-
?
additional information
?
-
-
rhPON3 can effectively delay and inhibit oxidation of high density lipoprotein in vitro
-
-
?
additional information
?
-
the enzyme can delay and inhibit low-density lipoprotein oxidation in a dose-dependent manner
-
-
?
additional information
?
-
the enzyme contains arylesterase, paraoxonase, and lactonase activities
-
-
?
additional information
?
-
-
the enzyme contains arylesterase, paraoxonase, and lactonase activities
-
-
?
additional information
?
-
the phenyl acetate esterase activity of paraoxonase-1 shows normal solvent kinetic isotope effects, while proton inventory analysis indicates that two protons contribute to the kinetic isotope effect. Moderate competitive inhibition with the phenyl methylphosphonate anion reveals that the rate-limiting transition state suboptimally resembles the tetrahedral intermediate. Despite the presence of the Ca2+-promoted oxyanion hole, the catalytic power can be mostly rationalized by concerted two-proton exchange reorganisation at the active site
-
-
?
additional information
?
-
-
the phenyl acetate esterase activity of paraoxonase-1 shows normal solvent kinetic isotope effects, while proton inventory analysis indicates that two protons contribute to the kinetic isotope effect. Moderate competitive inhibition with the phenyl methylphosphonate anion reveals that the rate-limiting transition state suboptimally resembles the tetrahedral intermediate. Despite the presence of the Ca2+-promoted oxyanion hole, the catalytic power can be mostly rationalized by concerted two-proton exchange reorganisation at the active site
-
-
?
additional information
?
-
-
the rate-limiting step is the nucleophilic attack of the carbonyl group of the substrate by a water molecule. The active site is preorganized with no induced fit, and the enzyme-bound calcium plays an important role in stabilizing both the substrate and the transition state
-
-
?
additional information
?
-
no activity with ethyl acetate, ethyl propionate, ethyl butanoate, ethyl pentanoate, propyl acetate, butyl acetate, hexanoyl acetate, and 4-nitrophenyl esters of chain length C10-C16
-
?
additional information
?
-
-
no activity with ethyl acetate, ethyl propionate, ethyl butanoate, ethyl pentanoate, propyl acetate, butyl acetate, hexanoyl acetate, and 4-nitrophenyl esters of chain length C10-C16
-
?
additional information
?
-
substrate specificity, no activity with 4-nitrophenyl caprate, 4-nitrophenyl laurate, 4-nitrophenyl phosphate, 4-nitrophenyl sulfate, 4-nitrophenyl beta-D-glucuronide, 4-nitrophenyl phenylphosphonate, stearoyl-CoA, palmitoyl-CoA, methylacetylsalicylate, ethyl acetate, propyl acetate, isopropyl acetate, butyl acetate, isobutyl acetate, isoamyl acetate, and caproyl acetate
-
?
additional information
?
-
substrate specificity, no activity with 4-nitrophenyl caprate, 4-nitrophenyl laurate, 4-nitrophenyl phosphate, 4-nitrophenyl sulfate, 4-nitrophenyl beta-D-glucuronide, 4-nitrophenyl phenylphosphonate, stearoyl-CoA, palmitoyl-CoA, methylacetylsalicylate, ethyl acetate, propyl acetate, isopropyl acetate, butyl acetate, isobutyl acetate, isoamyl acetate, and caproyl acetate
-
?
additional information
?
-
-
substrate specificity, no activity with 4-nitrophenyl caprate, 4-nitrophenyl laurate, 4-nitrophenyl phosphate, 4-nitrophenyl sulfate, 4-nitrophenyl beta-D-glucuronide, 4-nitrophenyl phenylphosphonate, stearoyl-CoA, palmitoyl-CoA, methylacetylsalicylate, ethyl acetate, propyl acetate, isopropyl acetate, butyl acetate, isobutyl acetate, isoamyl acetate, and caproyl acetate
-
?
additional information
?
-
-
does not use paraoxon as a substrate
-
-
?
additional information
?
-
PON1 is a lipo-lactonase which is associated with high density lipoprotein and possesses antioxidative properties
-
-
?
additional information
?
-
-
PON1 is a lipo-lactonase which is associated with high density lipoprotein and possesses antioxidative properties
-
-
?
additional information
?
-
molecular docking of substrates to wild-type and mutant enzymes using the crystal structure of PON1 (PDB ID 3SRG with resolution 2.19 A), overview. The enzyme is a paraoxonase (EC 3.1.8.1) that also shows arylesterase activity (EC 3.1.1.2) with phenyl acetate as substrate
-
-
?
additional information
?
-
-
the enzyme exhibits a substrate preference for short-chain fatty-acid esters such as C2 or C4 with an (R)-preference
-
-
?
additional information
?
-
-
can not hydrolyze organophosphates
-
-
?
additional information
?
-
no activity with 4-nitrophenyl decanoate
-
-
?
additional information
?
-
-
no activity with 4-nitrophenyl decanoate
-
-
?
additional information
?
-
no activity with 4-nitrophenyl decanoate
-
-
?
additional information
?
-
no activity with phenyl acetate, 4-nitrophenyl-decanoate or 3-phenyl acetate
-
-
?
additional information
?
-
-
no activity with phenyl acetate, 4-nitrophenyl-decanoate or 3-phenyl acetate
-
-
?
additional information
?
-
no activity with phenyl acetate, 4-nitrophenyl-decanoate or 3-phenyl acetate
-
-
?
additional information
?
-
-
no activity with 4-nitrophenyl caprylate and diclofop methyl
-
?
additional information
?
-
the enzyme has no activity towards 4-nitrophenyl esters with acyl chains longer than C8 like 4-nitrophenyl caprylate, 4-nitrophenyl caprate, 4-nitrophenyl palmitate, as well as 4-nitrophenyl phosphate and methyl parathion
-
-
?