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3.1.1.2: arylesterase

This is an abbreviated version!
For detailed information about arylesterase, go to the full flat file.

Word Map on EC 3.1.1.2

Reaction

a phenyl acetate
+
H2O
=
a phenol
 +
acetate

Synonyms

(R)-specific SGNH arylesterase, A-esterase, alpha-esterase, ARE, AREase, aromatic esterase, Aryl-ester hydrolase, aryldialkylphosphatase, arylesterase, DvvII, EST-1, EST-2, EST-3, ESt-A, Est0881, EstB, EstR5, G3C9 rePON1, gox0881, HDL-PON1, K-45, lp_1002, More, neuropathy target esterase-related esterase, NRE, NRECV, NTE-R1, NTE-related 1, NTE-related esterase, paraoxonase, paraoxonase 1, paraoxonase-1, paraoxonase/arylesterase, paraoxonase1, patatin-like phospholipase 7, phenyl acetate esterase, phenyl valerate esterase, PNPLA7, PON-aryl, PON1, PON1/Aryl, pyrethroid-resistance-associated esterase, Saci_2140, SacPox, serum paraoxonase/arylesterase 1, SGNH arylesterase, SGNH-arylesterase, SisLac, Sm23, Vmut2255, VmutPLL

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.1 Carboxylic-ester hydrolases
                3.1.1.2 arylesterase

Inhibitors

Inhibitors on EC 3.1.1.2 - arylesterase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-hydroxyquinoline
2-mercaptoethanol
2-propanol
55% residual activity in the presence of 90% (v/v) 2-propanol, after 60 min at 70°C
4-chloromercuribenzoate
6-palmityl-ascorbic acid
-
-
acetonitrile
43% residual activity in the presence of 90% (v/v) acetonitrile, after 60 min at 70°C
Ag+
9.7% residual activity at 5 mM
ascorbate
-
0.5 mM inhibits by ca. 19%. Ascorbate/Cu2+ (0.5 mM/0.001 mM) system shows ca. 91% inactivation
butylated hydroxytoluene
-
-
CdCl2
-
83% residual activity after 24 h in the presence of 0.02 mg/ml CdCl2
Cr3+
39.8% residual activity at 5 mM
D-penicillamine
-
40.5% residual activity after 24 h in the presence of 0.2 mg/ml D-penicillamine
diethyl dicarbonate
diethyldicarbonate
0.5 mM, complete loss of activity
diisopropyl fluorophosphate
diisopropylfluorophosphate
dimethyl sulfoxide
71% residual activity in the presence of 90% (v/v) dimethyl sulfoxide, after 60 min at 70°C
dimyristoylphosphatidic acid
0.4 mM, 81% inhibition of arylesterase activity, 64% inhibition of paraoxonase activity
dimyristoylphosphatidylserine
no significant inhibition of both paraoxonase and arylesterase activity up to 0.030 mM, remarkable inhibition of both activities at 0.1–0.4 mM, with a greater inhibition of arylesterase activity
dithiothreitol
19.4% residual activity at 5 mM
eserine
ethanol
Fe3+
13.7% residual activity at 5 mM
high density lipoprotein
-
incubation of serum or high density lipoprotein from healthy subjects with very low density lipoprotein significantly decreases serum paraoxonase 1 lactonase or arylesterase activities by up to 11% or 24%, and HDL-associated paraoxonase 1 lactonase or arylesterase activities by up to 32% or 46%, respectively
-
iodoacetic acid
slight inhibition
lanthanum(III) chloride
-
about 50% inhibition at 0.05 mM
methanol
48% residual activity in the presence of 90% (v/v) methanol, after 60 min at 70°C
methylglyoxal
-
decreases specific activity in a concentration-dependent manner
metrifonate
-
50% inhibition at 0.00048 mM, pralidoxime protects
N-ethylmaleimide
-
leads to 24fold reduced enzyme activity at 0.2 mM
nitrilotriacetic acid
-
organophosphorous compounds
inhibit the enzyme of all genotypes slightly after in vivo exposure
-
p-chloromercuribenzoate
p-hydroxymercuribenzoate
paraoxon
pepstatin A
phenyl acetate
Phenylglyoxal
phenylmethylsulfonyl fluoride
phosphatidylserine
-
-
piperonyl butoxide
-
50% inhibition at 0.6 mM. Enzyme inhibition in vivo reaches a maximum after 4 h and enzyme subsequently recovers over a 24 h period
pyridoxal 5'-phosphate
0.5 mM, 62% residual activity
sodium dodecylsulfate
1 mM, 32% of initial activity
sodium hypochlorite
-
at 1 mM causes approximately 15% decrease in activity, at 1 mM and in the presence of PBS buffer causes approximately 76% decrease in activity
tenoxicam
-
tenoxicam decreases the arylesterase activity of the enzyme during the use of 12 h, in 0.74 mM and 1.48 mM dose
Triton X-100
Tween 20
-
51% residual activity at 10% (v/v)
Tween 80
21% residual activity in the presence of 5% (v/v) Tween 80, after 60 min at 70°C
Valproic acid
arylesterase activity is decreased after 60 days of valproic acid treatment
very low density lipoprotein
-
inhibits recombinant paraoxonase 1 lactonase or arylesterase activities by up to 20% or 42%, respectively
-
additional information
-