Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.1.1.2: arylesterase

This is an abbreviated version!
For detailed information about arylesterase, go to the full flat file.

Word Map on EC 3.1.1.2

Reaction

a phenyl acetate
+
H2O
=
a phenol
 +
acetate

Synonyms

(R)-specific SGNH arylesterase, A-esterase, alpha-esterase, ARE, AREase, aromatic esterase, Aryl-ester hydrolase, aryldialkylphosphatase, arylesterase, DvvII, EST-1, EST-2, EST-3, ESt-A, Est0881, EstB, EstR5, G3C9 rePON1, gox0881, HDL-PON1, K-45, lp_1002, More, neuropathy target esterase-related esterase, NRE, NRECV, NTE-R1, NTE-related 1, NTE-related esterase, paraoxonase, paraoxonase 1, paraoxonase-1, paraoxonase/arylesterase, paraoxonase1, patatin-like phospholipase 7, phenyl acetate esterase, phenyl valerate esterase, PNPLA7, PON-aryl, PON1, PON1/Aryl, pyrethroid-resistance-associated esterase, Saci_2140, SacPox, serum paraoxonase/arylesterase 1, SGNH arylesterase, SGNH-arylesterase, SisLac, Sm23, Vmut2255, VmutPLL

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.1 Carboxylic-ester hydrolases
                3.1.1.2 arylesterase

Activating Compound

Activating Compound on EC 3.1.1.2 - arylesterase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,2-dilauroyl-phosphatidylcholine
-
stimulation
1-palmitoyl-2-arachidonoylphosphatidylcholine
stimulates arylesterase activity
1-palmitoyl-2-linoleoylphosphatidylcholine
stimulates arylesterase activity
3-[(3-cholamidopropyl)-dimethylammonio]-1-propanesulfonate
the enzyme is activated by 87% by incubation with 1% (w/v) 3-[(3-cholamidopropyl)-dimethylammonio]-1-propanesulfonate, at 30°C
aspirin
induces enzyme expression in the liver and stimulates enzymatic activity in blood plasma
Ca2+
-
required
cardiolipin
-
stimulates
cyclophosphamide
22% increase in the activity of PON1 in the liver and 23% increase in PON1 activity in the serum is observed 24 h after treatment with a single dose of 150 mg/kg cyclophosphamide
cysteine
1 mM, 117% of initial activity
di-oleoyl phosphatidylcholine
2.6 mM di-oleoyl phosphatidylcholine stimulates arylesterase activity of PON1 3.5fold
didecanoylphosphatidylcholine
stimulation of arylesterase activity is greater than stimulation of paraoxonase activity
dilauroyl phosphatidylcholine
dilauroylphosphatidylcholine
stimulation of arylesterase activity is greater than stimulation of paraoxonase activity
dilinoleoylphosphatidylcholine
stimulates arylesterase activity
dimethyl sulfoxide
21% increase of activity at 50% (v/v) dimethyl sulfoxide, at 30°C
dimyristoyl phosphatidylcholine
dimyristoylphosphatidylcholine
stimulation of arylesterase activity is greater than stimulation of paraoxonase activity
dimyristoylphosphatidylglycerol
activates the arylesterase activity and inhibits paraoxonase activity
dioleoyl phosphatidylcholine
dipalmitoylphosphatidylcholine
stimulation of arylesterase activity is greater than stimulation of paraoxonase activity
ethanol
high-density lipoprotein
paraoxonase and arylesterase activities are stimulated by high-density lipoprotein by 2-5fold, almost independently of the apoliporotein content
-
lecithin
Lubrol
the enzyme is activated by 14% by incubation with 1% Lubrol, at 30°C
-
lysolecithin
lysophosphatidylinositol
0.01 mM, 10% stimulation of arylesterase activity
Mg2+
-
Mg2, Mn2+ and other divalent metal ions can not substitute for Ca2+ and lead to a loss od arylesterase activity
Mn2+
-
Mg2, Mn2+ and other divalent metal ions can not substitute for Ca2+ and lead to a loss od arylesterase activity
monooleoyl-lysophosphatidylserine
0.01 mM, 8% stimulation of arylesterase activity
Nonidet P-40
8.2% activation at 5% (v/v)
palmitoyl-lysophosphatidylglycerol
0.01 mM, 47% stimulation of arylesterase activity
paraoxon
115 increase of activita in the presence of 0.5 mM paraoxon, after 30 min at 30°C
phosphate
phosphatidylcholine
-
purified A or B-type esterases are stimulated
phosphatidylethanolamine
phosphatidylglycerol
phosphatidylinositol
enhances arylesterase activity, but slightly decreases paraoxonase activity
phosphatidylsenine
-
stimulates
-
pyridoxal 5'-phosphate
110% activity in the presence of 5 mM pyridoxal 5'-phosphate, after 30 min at 30°C
salicylic acid
induces enzyme expression in the liver and stimulates enzymatic activity in blood plasma
sphingomyelin
-
stimulates
Triton X-100
Tween 20
Tween 40
16.4% activation at 5% (v/v)
Tween 80
additional information
-