3.1.1.10: tropinesterase
This is an abbreviated version!
For detailed information about tropinesterase, go to the full flat file.
Word Map on EC 3.1.1.10
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3.1.1.10
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scopolamine
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tropane
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prealbumin
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guinea-pigs
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muscarinic
- 3.1.1.10
- scopolamine
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tropane
-
prealbumin
- guinea-pigs
-
muscarinic
Reaction
Synonyms
AtrE, atropinase, Atropine acylhydrolase, atropine esterase, atropinesterase, esterase, tropine
ECTree
3.1.1.10 tropinesteraseAdvanced search results
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Substrates Products on EC 3.1.1.10 - tropinesterase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
butanilicain + H2O
?
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i.e. 2-butylamino-N-(2-chloro-6-methylphenyl)acetamide
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-
?
N(1,1-dimethyl-2-ureidoethyl)-2-hydroxy-3-(o-fluorobenzoyloxy)propylamine + H2O
?
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i.e. flestolol
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-
?
additional information
?
-
-
significant relationship between alkaloid accumulation in the leaves and atropine esterase activity in the roots of the regenerated plantlets
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-
?
additional information
?
-
-
the enzyme does not hydrolyze (R)-hyoscyamine
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-
?
additional information
?
-
-
the size of the nonpolar binding pocket in the active center region of this esterase allows a deeper penetration of the aromatic portions of the labels than is possible for the specificity pocket of alpha-chymotrypsin or subtilisin
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-
?
additional information
?
-
-
the active center region in AtrE resembles that of serine proteases with regard to the so-called charge-relay system, the oxyanion hole and the nonpolar binding crevice, suggesting that esterolysis by the enzyme proceeds according to a mechanism similar to that of proteolysis by alpha-chymotrypsin or subtilisin A
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-
?
additional information
?
-
-
the active center region in AtrE resembles that of serine proteases with regard to the so-called charge-relay system, the oxyanion hole and the nonpolar binding crevice, suggesting that esterolysis by the enzyme proceeds according to a mechanism similar to that of proteolysis by alpha-chymotrypsin or subtilisin A
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-
?
additional information
?
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the inducible enzyme is synthesized during growth on atropine and to a lesser extent during growth on 3-hydroxy-2-phenylpropionic acid, i.e. tropic acid and tropine
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-
?
additional information
?
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the inducible enzyme is synthesized during growth on atropine and to a lesser extent during growth on 3-hydroxy-2-phenylpropionic acid, i.e. tropic acid and tropine
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-
?
