2.3.1.147: glycerophospholipid arachidonoyl-transferase (CoA-independent)

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For detailed information about glycerophospholipid arachidonoyl-transferase (CoA-independent), go to the full flat file.

Word Map on EC 2.3.1.147

2.3.1.147

arachidonic

phospholipase

platelet-activating

paf

transacylation

coa-dependent

plasmalogens

1-acyl

ethanolamine-containing

alkylacylglycerophosphocholine

arachidonylated

arachidonoyl-coa

arachidonate-containing

alkylacyl-gpc

ether-containing

3harachidonate

aa-containing

ionophore-stimulated

3hlyso-paf

pharmacology

medicine

Reaction

1-organyl-2-arachidonoyl-sn-glycero-3-phosphocholine

1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine

1-organyl-2-arachidonoyl-sn-glycero-3-phosphoethanolamine

1-organyl-2-lyso-sn-glycero-3-phosphocholine

Synonyms

Acyltransferase, 1-alkylglycerophosphocholine, CoA-independent transacylase, CoA-IT, CoAIT, Coenzyme A-independent transacylase

ECTree

2 Transferases

2.3 Acyltransferases

2.3.1 Transferring groups other than aminoacyl groups

2.3.1.147 glycerophospholipid arachidonoyl-transferase (CoA-independent)

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Results	in table
2	Activating Compound
2	Application
1	CAS Registry Number
24	Disease/ Diagnostics
3	General Information
2	IC50 Value
21	Inhibitors
1	Ki Value [mM]
1	KM Value [mM]
3	Localization
11	Natural Substrates/ Products (Substrates)
16	Organism
3	pH Optimum
2	Reaction
1	Reaction Type
16	Reference
26	Source Tissue
27	Substrates and Products (Substrate)
12	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]

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Systematic Name on EC 2.3.1.147 - glycerophospholipid arachidonoyl-transferase (CoA-independent)

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1-organyl-2-arachidonoyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine arachidonoyltransferase (CoA-independent)

Catalyses the transfer of arachidonate and other polyenoic fatty acids from intact choline or ethanolamine-containing glycerophospholipids to the sn-2 position of a lyso-glycerophospholipid. The organyl group on sn-1 of the donor or acceptor molecule can be alkyl, acyl or alk-1-enyl. The term 'radyl' has sometimes been used to refer to such substituting groups. Differs from EC 2.3.1.148 glycerophospholipid acyltransferase (CoA-dependent) in not requiring CoA and in its specificity for poly-unsaturated acyl groups.