2.1.1.132: precorrin-6B C5,15-methyltransferase (decarboxylating)

This is an abbreviated version!
For detailed information about precorrin-6B C5,15-methyltransferase (decarboxylating), go to the full flat file.

Reaction

2 S-adenosyl-L-methionine +

= 2 S-adenosyl-L-homocysteine +

Synonyms

CobL, GenBank L12005-derived protein, Genbank L12006-derived protein, GenBank U67594-derived protein GI 1500413, Gene cbiE precorrin 6y methylase, Gene cbiT precorrin methylase, Methyltransferase precorrin 6y (Salmonella typhimurium strain LT2 gene cbiE), methyltransferase, precorrin 6y, Methyltransferase, precorrin 6y (Methanococcus jannaschii), Methyltransferase, precorrin 6y (Salmonella typhimurium strain LT2 gene cbiT), Precorrhin-6y methyltransferase, Precorrin-6 methyltransferase, Precorrin-6Y methylase, precorrin-6y methyltransferase, precorrin-8w decarboxylase, Protein (Salmonella typhimurium clone pJO gene cbiE reduced), Protein (Salmonella typhimurium clone pJO26 gene cbiT reduced)

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.132 precorrin-6B C5,15-methyltransferase (decarboxylating)

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1964	AA Sequence
7	CAS Registry Number
3	Cloned(Commentary)
1	Crystallization (Commentary)
1	KM Value [mM]
6	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
10	Organism
4	Pathway
10	PDB ID
2	Purification (Commentary)
5	Reaction
1	Reaction Type
9	Reference
1	Specific Activity [micromol/min/mg]
16	Substrates and Products (Substrate)
7	Subunits
17	Synonyms
1	Systematic Name

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Systematic Name on EC 2.1.1.132 - precorrin-6B C5,15-methyltransferase (decarboxylating)

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S-adenosyl-L-methionine:1-precorrin-6B C5,15-methyltransferase (C-12-decarboxylating)

The enzyme participates in the aerobic (late cobalt insertion) adenosylcobalamin biosynthesis pathway. The enzyme from the bacterium Pseudomonas denitrificans is a fusion protein with two active sites; one catalyses the methylation at C-15 followed by decarboxylation of the C-12 acetate side chain, while the other catalyses the methylation at C-5. The corresponding activities in the anaerobic adenosylcobalamin biosynthesis pathway are catalysed by EC 2.1.1.196, cobalt-precorrin-6B (C15)-methyltransferase [decarboxylating], and EC 2.1.1.289, cobalt-precorrin-7 (C5)-methyltransferase, respectively.