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1.8.98.5: H2:CoB-CoM heterodisulfide,ferredoxin reductase

This is an abbreviated version!
For detailed information about H2:CoB-CoM heterodisulfide,ferredoxin reductase, go to the full flat file.

Wordmap for 1.8.98.5

Word Map on EC 1.8.98.5 Wordmap for 1.8.98.5

Reaction

2 reduced ferredoxin [iron-sulfur] cluster +

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CoB
+
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CoM
+ 2 H+ = 2 H2 + 2 oxidized ferredoxin [iron-sulfur] cluster +
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CoM-S-S-CoB

Synonyms

CoB-CoM heterodisulfide reductase, F420-non-reducing hydrogenase, H2-driven FBEB, H2: CoM-S-S-CoB oxidoreductase, H2: heterodisulfide oxidoreductase complex, HdrA, hdrA1B1C1, HdrABC, HdrABC-MvhAGD, HdrB, HdrC, HdrDE, HdrDE-VhoGAC, heterodisulfide reductase, heterodisulfide reductase complex, hydrogenase, More, Mvh, MvhA, MvhADG, MvhADG/HdrABC, MvhD, MvhG, VhoGAC, Vhu

ECTree

     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.98 With other, known, physiological acceptors
                EC 1.8.98.51.8.98.5 H2:CoB-CoM heterodisulfide,ferredoxin reductase

Systematic Name

Systematic Name on EC 1.8.98.5 - H2:CoB-CoM heterodisulfide,ferredoxin reductase

for references in articles please use BRENDA:EC1.8.98.5

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SYSTEMATIC NAME
IUBMB Comments
CoB,CoM,ferredoxin:H2 oxidoreductase
This enzyme complex is found in H2-oxidizing CO2-reducing methanogenic archaea such as Methanothermobacter thermautotrophicus. It consists of a cytoplasmic complex of HdrABC reductase and MvhAGD hydrogenase. Electron pairs donated by the hydrogenase are transferred via its delta subunit to the HdrA subunit of the reductase, where they are bifurcated, reducing both ferredoxin and CoB-CoM heterodisulfide. The reductase can also form a similar complex with formate dehydrogenase, see EC 1.8.98.6, formate:CoB-CoM heterodisulfide,ferredoxin reductase. cf. EC 1.8.7.3, ferredoxin:CoB-CoM heterodisulfide reductase, EC 1.8.98.4, coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase, and EC 1.8.98.1, dihydromethanophenazine:CoB-CoM heterodisulfide reductase.