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HdrABC is an enzyme complex that is found in most methanogens and catalyses the reduction of the CoB-CoM heterodisulfide back to CoB and CoM. HdrA contains a FAD cofactor that acts as the entry point for electrons, which are transferred via HdrC to the HdrB catalytic subunit. One form of the enzyme from Methanosarcina acetivorans (HdrA2B2C2) can also catalyse EC 220.127.116.11, coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase. cf. EC 18.104.22.168, H2:CoB-CoM heterodisulfide,ferredoxin reductase, EC 22.214.171.124, formate:CoB-CoM heterodisulfide,ferredoxin reductase, and EC 126.96.36.199, dihydromethanophenazine:CoB-CoM heterodisulfide reductase.