ferredoxin:CoB-CoM heterodisulfide reductase

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For detailed information about ferredoxin:CoB-CoM heterodisulfide reductase, go to the full flat file.


2 oxidized ferredoxin [iron-sulfur] cluster +

= 2 reduced ferredoxin [iron-sulfur] cluster +
+ 2 H+


heterodisulfide reductase, HdrB, Coenzyme B-Coenzyme M heterodisulfide reductase, CoB-S-S-CoM reductase, HdrABC, hdrA1B1C1, hdrA2B2C2, HdrB2, HdrB2C2


     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.7 With an iron-sulfur protein as acceptor
       ferredoxin:CoB-CoM heterodisulfide reductase

Systematic Name

Systematic Name on EC - ferredoxin:CoB-CoM heterodisulfide reductase

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IUBMB Comments
CoB,CoM:ferredoxin oxidoreductase
HdrABC is an enzyme complex that is found in most methanogens and catalyses the reduction of the CoB-CoM heterodisulfide back to CoB and CoM. HdrA contains a FAD cofactor that acts as the entry point for electrons, which are transferred via HdrC to the HdrB catalytic subunit. One form of the enzyme from Methanosarcina acetivorans (HdrA2B2C2) can also catalyse EC, coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase. cf. EC, H2:CoB-CoM heterodisulfide,ferredoxin reductase, EC, formate:CoB-CoM heterodisulfide,ferredoxin reductase, and EC, dihydromethanophenazine:CoB-CoM heterodisulfide reductase.