1.8.5.B1: peptide-methionine (S)-S-oxide reductase (quinone)

This is an abbreviated version!
For detailed information about peptide-methionine (S)-S-oxide reductase (quinone), go to the full flat file.

Reaction

Synonyms

MsrP, MsrQ, protein-methionine-sulfoxide reductase, YedY, YedZ

ECTree

     1 Oxidoreductases

         1.8 Acting on a sulfur group of donors

             1.8.5 With a quinone or similar compound as acceptor

                1.8.5.B1 peptide-methionine (S)-S-oxide reductase (quinone)

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Results	in table
1	Cloned(Commentary)
2	Cofactor
1	Crystallization (Commentary)
1	Expression
1	General Information
5	kcat/KM [mM/s]
8	KM Value [mM]
2	Localization
1	Metals/Ions
3	Organism
3	Protein Variants
1	Reaction
3	Reference
14	Substrates and Products (Substrate)
2	Subunits
5	Synonyms
1	Systematic Name
5	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 1.8.5.B1 - peptide-methionine (S)-S-oxide reductase (quinone)

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

dimethyl sulfoxide + reduced benzyl viologen

dimethyl sulfide + oxidized benzyl viologen + H2O

Escherichia coli

P76342; P76343

-

742828

-

-

?

L-methionine (R)-S-oxide + reduced benzyl viologen

L-methionine + oxidized benzyl viologen + H2O

Escherichia coli

P76342; P76343

-

743348

-

-

?

L-methionine (S)-S-oxide + reduced benzyl viologen

L-methionine + oxidized benzyl viologen + H2O

Escherichia coli

P76342; P76343

-

743348

-

-

?

L-methionine S-oxide in chaperone SurA + reduced benzyl viologen

L-methionine in chaperone SurA + oxidized benzyl viologen + H2O

Escherichia coli

P76342; P76343

-

743348

-

-

?

L-methionine S-oxide in lipoprotein Pal + reduced benzyl viologen

L-methionine in lipoprotein Pal + oxidized benzyl viologen + H2O

Escherichia coli

P76342; P76343

-

743348

-

-

?

L-methionine sulfoxide + reduced benzyl viologen

L-methionine + oxidized benzyl viologen + H2O

Escherichia coli

P76342; P76343

-

742828

-

-

?

N-acetyl-L-methionine (S)-sulfoxide + reduced benzyl viologen

N-acetyl-L-methionine + oxidized benzyl viologen + H2O

Escherichia coli

P76342; P76343

-

743348

-

-

?

oxidized calmodulin + reduced benzyl viologen

reduced calmodulin + oxidized benzyl viologen + H2O

Escherichia coli

P76342; P76343

-

743348

-

-

?

tetrahydrothiophene oxide + reduced benzyl viologen

tetrahydrothiophene + oxidized benzyl viologen + H2O

Escherichia coli

P76342; P76343

-

742828

-

-

?

trimethylamine N-oxide + reduced benzyl viologen

trimethylamine + oxidized benzyl viologen + H2O

Escherichia coli

P76342; P76343

-

742828

-

-

?

[protein]-L-methionine + a quinone + H2O

[protein]-L-methionine (R)-S-oxide + a quinol

Escherichia coli

P76342; P76343

-

742907

-

-

r

[protein]-L-methionine + a quinone + H2O

[protein]-L-methionine (S)-S-oxide + a quinol

Escherichia coli

P76342; P76343

-

742907

-

-

r

additional information

?

-

2 entries

additional information

?

-

Escherichia coli

P76342; P76343

MsrPQ is able to reduce both R- and S-diastereoisomers of methionine sulfoxide

743348

-

-

?

additional information

?

-

Escherichia coli

P76342; P76343

subunit MsrQ is reduced due to the free reduced FMN generated by the flavin reductase Fre activity

742907

-

-

?