1.8.5.1: glutathione dehydrogenase (ascorbate)
This is an abbreviated version!
For detailed information about glutathione dehydrogenase (ascorbate), go to the full flat file.
Word Map on EC 1.8.5.1
-
1.8.5.1
-
metallothioneins
-
dismutase
-
monodehydroascorbate
-
catalase
-
sod
-
seedlings
-
cadmium
-
chlorophyl
-
ascorbate-glutathione
-
malondialdehyde
-
s-transferase
-
chloroplast
-
zn
-
copper
-
shoot
-
1.6.4.2
-
asa-gsh
-
drought
-
1.11.1.11
-
gssg
-
melanocortins
-
guaiacol
-
glyoxalase
-
omega
-
metal-binding
-
glutathione-s-transferase
-
thioltransferase
-
yam
-
l-galactose
-
cadmium-induced
-
dioscorea
-
l-ascorbic
-
foliar
-
gsh-dependent
-
methylglyoxal
-
alpha-msh
-
cd-induced
-
hydroponic
-
glutaredoxins
-
l-galactono-1,4-lactone
-
bothrops
-
xanthophyl
-
pradesh
-
medicine
-
agriculture
-
photoinhibition
-
fe-sod
-
phytochelatins
-
asper
-
beta-domains
- 1.8.5.1
- metallothioneins
- dismutase
- monodehydroascorbate
- catalase
- sod
- seedlings
- cadmium
-
chlorophyl
-
ascorbate-glutathione
- malondialdehyde
- s-transferase
- chloroplast
- zn
- copper
- shoot
-
1.6.4.2
-
asa-gsh
- drought
-
1.11.1.11
- gssg
-
melanocortins
- guaiacol
- glyoxalase
- omega
-
metal-binding
- glutathione-s-transferase
- thioltransferase
- yam
- l-galactose
-
cadmium-induced
- dioscorea
-
l-ascorbic
-
foliar
-
gsh-dependent
- methylglyoxal
- alpha-msh
-
cd-induced
-
hydroponic
- glutaredoxins
- l-galactono-1,4-lactone
- bothrops
-
xanthophyl
-
pradesh
- medicine
- agriculture
-
photoinhibition
- fe-sod
- phytochelatins
- asper
-
beta-domains
Reaction
2 glutathione
+
Synonyms
At1g19570, At1g75270, At5g16710, AtDHAR, AtDHAR1, AtDHAR2, AtDHAR3, CrDHAR1, DasA reductase, dehydroascorbate reductase, dehydroascorbate reductase 2, dehydroascorbic acid reductase, dehydroascorbic reductase, dehydrogenase, glutathione (ascorbate), DHA reductase, DHA-R, DHAR, DHAR1, DHAR2, DHAR3, DHAR3a, DHAR4, DHAR5, dioscorin, GDOR, glutathione dehydroascorbate reductase, glutathione-dependent dehydroascorate reductase, glutathione:dehydroascorbic acid oxidoreductase, GRX1, GRX2, GSH-DHAR, GSH:DHA-oxidoreductase, GSTO, GSTO1, GSTO1-1, GSTO2, GSTO2-2, LcDHAR, metallothionein-1, metallothionein-2, More, MT-I, MT-II, nlGSTO, OsDHAR, OsDHAR1, PbDHAR, PgDHAR1, PtrDHAR1, PtrDHAR2, PtrDHAR3A, PtrDHAR3B, SPD1
ECTree
1.8.5.1 glutathione dehydrogenase (ascorbate)Advanced search results
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results (Substrates Products
Substrates Products on EC 1.8.5.1 - glutathione dehydrogenase (ascorbate)
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-acetylcysteine + dehydroascorbate
N,N'-diacetyl-L-cystine + ascorbate
-
4% of the activity with GSH
-
-
?
2 glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
-
?
2 glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
-
?
2 glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
?
2 glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
?
2 glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
?
2 glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
?
2 glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
?
2 glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
?
2 glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
?
2 glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
?
2 glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
?
2 glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
?
2 glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
?
2 glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
?
2 glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
?
2 glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
?
2 glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
?
2 glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
-
?
2 glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
?
2 glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
?
2 glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
?
2 glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
?
2 glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
?
2 glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
?
2 glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
?
2 glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
?
2 glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
?
2 glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
?
glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
-
?
glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
-
?
glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
?
glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
-
?
glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
-
?
glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
?
glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
?
glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
-
?
glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
?
glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
?
glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
?
glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
?
glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
?
glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
-
?
glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
-
?
glutathione + dehydroascorbate
glutathione disulfide + ascorbate
-
-
-
-
?
glutathione + dehydroascorbate
GSSG + ascorbate
-
vitamin C-conserving mechanism
-
?
glutathione + dehydroascorbate
GSSG + ascorbate
-
the enzyme is critical for maintenance of an appropriate level of ascorbate in plant cells
-
-
?
glutathione + dehydroascorbate
GSSG + ascorbate
-
regenerates ascorbate after it is oxidized during normal aerobic metabolism
-
-
?
GSH + dehydroascorbate
GSSG + ascorbate
-
specific for glutathione as hydrogen donor
-
-
?
GSH + dehydroascorbate
GSSG + ascorbate
-
-
-
-
?
GSH + dehydroascorbate
GSSG + ascorbate
-
L-threo-diastereomer is reduced faster than the L-erythro-dehydroascorbate and D-erythro-dehydroascorbate
-
-
?
GSH + dehydroascorbate
GSSG + ascorbate
-
specific for glutathione as hydrogen donor
-
-
?
GSH + dehydroascorbate
GSSG + ascorbate
-
L-threo-dehydroascorbate is the best and D-threo-dehydroascorbate is the worst substrate of the four dehydroascorbate stereoisomers
-
-
?
additional information
?
-
-
while the reduction of dehydroascorbate (DHA) to ascorbate can occur chemically at significant rates, DHAR is able to accelerate the reaction, in both cases reduced glutathione (GSH) is used as the reductant
-
-
-
additional information
?
-
-
while the reduction of dehydroascorbate (DHA) to ascorbate can occur chemically at significant rates, DHAR is able to accelerate the reaction, in both cases reduced glutathione (GSH) is used as the reductant
-
-
-
additional information
?
-
the activity of DHARs is coupled to oxidation of glutathione, which is also required for spontaneous, nonenzymatic reduction of DHA to ascorbate
-
-
-
additional information
?
-
the activity of DHARs is coupled to oxidation of glutathione, which is also required for spontaneous, nonenzymatic reduction of DHA to ascorbate
-
-
-
additional information
?
-
the activity of DHARs is coupled to oxidation of glutathione, which is also required for spontaneous, nonenzymatic reduction of DHA to ascorbate
-
-
-
additional information
?
-
while the reduction of dehydroascorbate (DHA) to ascorbate can occur chemically at significant rates, DHAR is able to accelerate the reaction, in both cases reduced glutathione (GSH) is used as the reductant
-
-
-
additional information
?
-
while the reduction of dehydroascorbate (DHA) to ascorbate can occur chemically at significant rates, DHAR is able to accelerate the reaction, in both cases reduced glutathione (GSH) is used as the reductant
-
-
-
additional information
?
-
while the reduction of dehydroascorbate (DHA) to ascorbate can occur chemically at significant rates, DHAR is able to accelerate the reaction, in both cases reduced glutathione (GSH) is used as the reductant
-
-
-
additional information
?
-
while the reduction of dehydroascorbate (DHA) to ascorbate can occur chemically at significant rates, DHAR is able to accelerate the reaction, in both cases reduced glutathione (GSH) is used as the reductant
-
-
-
additional information
?
-
-
while the reduction of dehydroascorbate (DHA) to ascorbate can occur chemically at significant rates, DHAR is able to accelerate the reaction, in both cases reduced glutathione (GSH) is used as the reductant
-
-
-
additional information
?
-
-
while the reduction of dehydroascorbate (DHA) to ascorbate can occur chemically at significant rates, DHAR is able to accelerate the reaction, in both cases reduced glutathione (GSH) is used as the reductant
-
-
-
additional information
?
-
while the reduction of dehydroascorbate (DHA) to ascorbate can occur chemically at significant rates, DHAR is able to accelerate the reaction, in both cases reduced glutathione (GSH) is used as the reductant
-
-
-
additional information
?
-
GRX1is a typical CPYC-type GRX, which is reduced by GSH and exhibits disulfide reductase, dehydroascorbate reductase, and deglutathionylation activities
-
-
-
additional information
?
-
-
GRX1is a typical CPYC-type GRX, which is reduced by GSH and exhibits disulfide reductase, dehydroascorbate reductase, and deglutathionylation activities
-
-
-
additional information
?
-
-
while the reduction of dehydroascorbate (DHA) to ascorbate can occur chemically at significant rates, DHAR is able to accelerate the reaction, in both cases reduced glutathione (GSH) is used as the reductant
-
-
-
additional information
?
-
while the reduction of dehydroascorbate (DHA) to ascorbate can occur chemically at significant rates, DHAR is able to accelerate the reaction, in both cases reduced glutathione (GSH) is used as the reductant
-
-
-
additional information
?
-
while the reduction of dehydroascorbate (DHA) to ascorbate can occur chemically at significant rates, DHAR is able to accelerate the reaction, in both cases reduced glutathione (GSH) is used as the reductant
-
-
-
additional information
?
-
-
the activity of DHARs is coupled to oxidation of glutathione, which is also required for spontaneous, nonenzymatic reduction of DHA to ascorbate
-
-
-
additional information
?
-
enzyme nlGSTO shows broad substrate specificity as thiol transferase, see also EC 2.5.1.18
-
-
-
additional information
?
-
-
enzyme nlGSTO shows broad substrate specificity as thiol transferase, see also EC 2.5.1.18
-
-
-
additional information
?
-
while the reduction of dehydroascorbate (DHA) to ascorbate can occur chemically at significant rates, DHAR is able to accelerate the reaction, in both cases reduced glutathione (GSH) is used as the reductant
-
-
-
additional information
?
-
while the reduction of dehydroascorbate (DHA) to ascorbate can occur chemically at significant rates, DHAR is able to accelerate the reaction, in both cases reduced glutathione (GSH) is used as the reductant
-
-
-
additional information
?
-
-
while the reduction of dehydroascorbate (DHA) to ascorbate can occur chemically at significant rates, DHAR is able to accelerate the reaction, in both cases reduced glutathione (GSH) is used as the reductant
-
-
-
additional information
?
-
no substrates: 1-chloro-2,4-dinitrobenzene, 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole, nitrobutyl chloride, 4-nitrophenyl acetate, 1,2-dichloro-4-nitrobenzene
-
-
?
additional information
?
-
no substrates: 1-chloro-2,4-dinitrobenzene, 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole, nitrobutyl chloride, 4-nitrophenyl acetate, 1,2-dichloro-4-nitrobenzene
-
-
?
additional information
?
-
no substrates: 1-chloro-2,4-dinitrobenzene, 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole, nitrobutyl chloride, 4-nitrophenyl acetate, 1,2-dichloro-4-nitrobenzene
-
-
?
additional information
?
-
-
no substrates: 1-chloro-2,4-dinitrobenzene, 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole, nitrobutyl chloride, 4-nitrophenyl acetate, 1,2-dichloro-4-nitrobenzene
-
-
?
additional information
?
-
while the reduction of dehydroascorbate (DHA) to ascorbate can occur chemically at significant rates, DHAR is able to accelerate the reaction, in both cases reduced glutathione (GSH) is used as the reductant
-
-
-
additional information
?
-
while the reduction of dehydroascorbate (DHA) to ascorbate can occur chemically at significant rates, DHAR is able to accelerate the reaction, in both cases reduced glutathione (GSH) is used as the reductant
-
-
-
additional information
?
-
while the reduction of dehydroascorbate (DHA) to ascorbate can occur chemically at significant rates, DHAR is able to accelerate the reaction, in both cases reduced glutathione (GSH) is used as the reductant
-
-
-
additional information
?
-
-
while the reduction of dehydroascorbate (DHA) to ascorbate can occur chemically at significant rates, DHAR is able to accelerate the reaction, in both cases reduced glutathione (GSH) is used as the reductant
-
-
-
additional information
?
-
while the reduction of dehydroascorbate (DHA) to ascorbate can occur chemically at significant rates, DHAR is able to accelerate the reaction, in both cases reduced glutathione (GSH) is used as the reductant
-
-
-
additional information
?
-
while the reduction of dehydroascorbate (DHA) to ascorbate can occur chemically at significant rates, DHAR is able to accelerate the reaction, in both cases reduced glutathione (GSH) is used as the reductant
-
-
-
additional information
?
-
while the reduction of dehydroascorbate (DHA) to ascorbate can occur chemically at significant rates, DHAR is able to accelerate the reaction, in both cases reduced glutathione (GSH) is used as the reductant
-
-
-
additional information
?
-
no activity with NADPH, alpha-lipoic acid, or DL-lipoamide as electron donors. The enzyme is GSH-dependent
-
-
-
additional information
?
-
-
no activity with NADPH, alpha-lipoic acid, or DL-lipoamide as electron donors. The enzyme is GSH-dependent
-
-
-
additional information
?
-
while the reduction of dehydroascorbate (DHA) to ascorbate can occur chemically at significant rates, DHAR is able to accelerate the reaction, in both cases reduced glutathione (GSH) is used as the reductant
-
-
-
additional information
?
-
while the reduction of dehydroascorbate (DHA) to ascorbate can occur chemically at significant rates, DHAR is able to accelerate the reaction, in both cases reduced glutathione (GSH) is used as the reductant
-
-
-
additional information
?
-
-
glutathione-dependent dehydroascorbate reductase activity of thioltransferase (glutaredoxin)
-
-
?
additional information
?
-
-
L-Cys-L-Gly is not active as hydrogen donor
-
-
?
additional information
?
-
the activity of DHARs is coupled to oxidation of glutathione, which is also required for spontaneous, nonenzymatic reduction of DHA to ascorbate
-
-
-
