1.8.4.8: phosphoadenylyl-sulfate reductase (thioredoxin) This is an abbreviated version! For detailed information about phosphoadenylyl-sulfate reductase (thioredoxin), go to the full flat file .
Word Map on EC 1.8.4.8
Reaction
adenosine 3',5'-bisphosphate +
sulfite +
thioredoxin disulfide =
3'-phosphoadenylyl sulfate +
thioredoxin
Synonyms 3'-Phosphoadenosine 5'-phosphosulfate reductase, 3'-Phosphoadenylylsulfate reductase, 4Fe-4S adenylyl sulfate/phosphoadenylyl sulfate reductase, 5'-adenylylsulfate reductase, Adenosine 3'-phosphate 5'-phosphosulfate reductase, adenosine 5'-phosphosulfate reductase, Adenylyl phosphosulfate reductase, APR, APS reductase, CysH1, EC 1.8.99.4, PAdoPS reductase, PAPS reductase, PAPS reductase, thioredoxin dependent, PAPS reductase, thioredoxin-dependent, PAPS sulfotransferase, Phospho-adenylylsulfate (PAPS) reductase, Phospho-adenylylsulfate reductase, Reductase, 3'-phosphoadenosine 5'-phosphosulfate, SNR, Thioredoxin: 3'-phospho-adenylylsulfate reductase, Thioredoxin:adenosine 3'-phosphate 5'-phosphosulfate reductase
ECTree
Natural Substrates Products
Natural Substrates Products on EC 1.8.4.8 - phosphoadenylyl-sulfate reductase (thioredoxin)
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3'-adenylyl-sulfate + thioredoxin
adenosine 3',5'-bisphosphate + thioredoxin disulfide + sulfite
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3'-phosphoadenylyl-sulfate + glutaredoxin
adenosine 3',5'-bisphosphate + glutaredoxin disulfide + sulfite
3'-phosphoadenylyl-sulfate + thioredoxin
adenosine 3',5'-bisphosphate + thioredoxin disulfide + sulfite
5-Phosphoadenosine 3-phosphosulfate + reduced thioredoxin
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3'-phosphoadenylyl-sulfate + glutaredoxin
adenosine 3',5'-bisphosphate + glutaredoxin disulfide + sulfite
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3'-phosphoadenylyl-sulfate + glutaredoxin
adenosine 3',5'-bisphosphate + glutaredoxin disulfide + sulfite
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3'-phosphoadenylyl-sulfate + thioredoxin
adenosine 3',5'-bisphosphate + thioredoxin disulfide + sulfite
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3'-phosphoadenylyl-sulfate + thioredoxin
adenosine 3',5'-bisphosphate + thioredoxin disulfide + sulfite
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3'-phosphoadenylyl-sulfate + thioredoxin
adenosine 3',5'-bisphosphate + thioredoxin disulfide + sulfite
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enzyme catalyzes the first reductive step in sulfate assimilation
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5-Phosphoadenosine 3-phosphosulfate + reduced thioredoxin
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enzyme is involved in sulfur metabolism
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5-Phosphoadenosine 3-phosphosulfate + reduced thioredoxin
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essential step in the biosynthesis of Cys in E. coli. Blocking of the enzyme inhibits cell growth
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enzyme is essential for sulfate assimilation using phosphoadenosine 5'-phosphosulfate, not adenosine 5'-phosphosulfate, phylogenetic comparison of the 2 different groups, overview
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enzyme is involved in sulfate assimilation requiring reduced glutathione and glutaredoxins, redox regulation of the enzyme by glutathione and glutaredoxins, overview
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thioredoxin1 and glutaredoxin 1 are essential for sulfate reduction but not for ribonucleotide reduction
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