1.8.4.4: glutathione-cystine transhydrogenase

This is an abbreviated version!
For detailed information about glutathione-cystine transhydrogenase, go to the full flat file.

Reaction

2 glutathione +

Synonyms

GSH-cystine transhydrogenase, NADPH-dependent GSH-cystine transhydrogenase, transhydrogenase, glutathione-cystine

ECTree

     1 Oxidoreductases

         1.8 Acting on a sulfur group of donors

             1.8.4 With a disulfide as acceptor

                1.8.4.4 glutathione-cystine transhydrogenase

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Results	in table
1	Activating Compound
1	CAS Registry Number
8	General Stability
9	Inhibitors
2	KM Value [mM]
4	Localization
1	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
6	Organism
5	Pathway
2	pH Optimum
1	pH Range
3	Purification (Commentary)
1	Reaction
3	Reaction Type
6	Reference
6	Source Tissue
2	Specific Activity [micromol/min/mg]
3	Storage Stability
23	Substrates and Products (Substrate)
3	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
3	Temperature Stability [°C]

Substrates Products

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Substrates Products on EC 1.8.4.4 - glutathione-cystine transhydrogenase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

beta-hydroxyethyl disulfide + GSH

?

Saccharomyces cerevisiae

-

-

395014

-

-

?

cystine + GSH

cysteine + GSSG

2 entries

D-cystine + 2 GSH

2 D-cysteine + GSSG

Saccharomyces cerevisiae

-

-

395014

-

-

?

diacetyl-L-cystine + GSH

?

Saccharomyces cerevisiae

-

-

395014

-

-

?

dimethyl disulfide + GSH

?

Saccharomyces cerevisiae

-

-

395016

-

-

?

dithiodiglycolic acid + GSH

?

Saccharomyces cerevisiae

-

-

395016

-

-

?

GSSG + GSH

GSSG + GSH

Saccharomyces cerevisiae

-

-

395016

-

-

?

homocystine + GSH

?

Saccharomyces cerevisiae

-

-

395014, 395016

-

-

?

L-cystine + GSH

L-cysteine + GSSG

Saccharomyces cerevisiae

-

-

395014

-

-

?

L-cystine diamide + GSH

?

Saccharomyces cerevisiae

-

-

395014

-

-

?

L-cystinyldiglycine + GSH

L-Cys-Gly-Gly + GSSG

Saccharomyces cerevisiae

-

-

395014

-

-

?

lipoic acid oxidized + GSH

?

Saccharomyces cerevisiae

-

-

395016

-

-

?

additional information

?

-

5 entries

cystine + GSH

cysteine + GSSG

Rattus norvegicus

-

-

395017, 395018, 395019

-

-

?

cystine + GSH

cysteine + GSSG

Saccharomyces cerevisiae

-

-

395014, 395015, 395016

-

-

?

additional information

?

-

Saccharomyces cerevisiae

-

inactive with albumin and kreatin

395016

-

-

?

additional information

?

-

Saccharomyces cerevisiae

-

inactive with: insulin and other proteins

395015

-

-

?

additional information

?

-

Saccharomyces cerevisiae

-

at low substrate concentration the reaction rate is greater with L-cystine than with any of the other substances

395014

-

-

?

additional information

?

-

Saccharomyces cerevisiae

-

at low substrate concentration the reaction rate is greater with L-cystine than with any of the other substances

395015

-

-

?

additional information

?

-

Saccharomyces cerevisiae

-

at low substrate concentration the reaction rate is greater with L-cystine than with any of the other substances

395016

-

-

?