1.8.4.2: protein-disulfide reductase (glutathione)

This is an abbreviated version!
For detailed information about protein-disulfide reductase (glutathione), go to the full flat file.

Reaction

2 glutathione +

Synonyms

BbdC, BdbD, C1orf31, CatA protein, ccdA associated thiol-disulfide oxidoreductase, COA6, DcbA, desulfothioredoxin, DIP1880, disulfide bond-forming thiol-disulfide oxidoreductase, disulphide interchange enzyme, DsbA, DsbA1, DsbA2, Dtrx, ERp57, GIT, glutathione-insulin transhydrogenase, glutathione-protein disulfide oxidoreductase, GRX1, GRX2, GRX3, GRX5, GRX6, GrxS12, GSH-dependent protein disulfide oxidoreductase, GSH-insulin transhydrogenase, HP_0231, insulin reductase, mcrophage migration inhibitory factor-2, MdbA, MdbACm, membrane-bound thiol-disulfide oxidoreductase, Mif-2, More, protein disulfide reductase (glutathione), protein disulfide transhydrogenase, protein-disulfide interchange enzyme, protein-disulfide isomerase/oxidoreductase, RCAP_rcc01743, reductase, protein disulfide (glutathione), ResA, SdbA, SGO_2006, SpyM18_2037, StoA, Streptococcus disulfide bond protein A, TDOR, thiol disulfide oxidoreductase, thiol-disulfide oxidoreductase, thiol-protein disulphide oxidoreductase, thiol:disulfide oxidoreductase, thiol:protein-disulfide oxidoreductase, WhiB1, WhiB1/Rv3219, YkuV, YMR244C-A

ECTree

     1 Oxidoreductases

         1.8 Acting on a sulfur group of donors

             1.8.4 With a disulfide as acceptor

                1.8.4.2 protein-disulfide reductase (glutathione)

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Results	in table
32	Activating Compound
843	AA Sequence
1	Application
1	CAS Registry Number
23	Cloned(Commentary)
6	Crystallization (Commentary)
45	Disease/ Diagnostics
76	General Information
8	General Stability
101	Inhibitors
5	kcat/KM [mM/s]
2	Ki Value [mM]
51	KM Value [mM]
44	Localization
5	Metals/Ions
32	Molecular Weight [Da]
73	Natural Substrates/ Products (Substrates)
164	Organism
2	Pathway
31	PDB ID
14	pH Optimum
4	pH Range
5	Posttranslational Modification
47	Protein Variants
32	Purification (Commentary)
15	Reaction
3	Reaction Type
146	Reference
127	Source Tissue
38	Specific Activity [micromol/min/mg]
2	Storage Stability
313	Substrates and Products (Substrate)
30	Subunits
160	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]
5	Temperature Stability [°C]
11	Turnover Number [1/s]

General Stability

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General Stability on EC 1.8.4.2 - protein-disulfide reductase (glutathione)

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GENERAL STABILITY

ORGANISM

UNIPROT

LITERATURE

dimerization after prolonged storage at -20°C, freeze-thawing or heating at 60°C

Bos taurus

-

394836

EDTA 5mM, 37°C, phosphate buffer, total loss of activity within 30-60 min, can partially be prevented by NADPH

Rattus norvegicus

-

394815

EDTA stabilizes during purification

2 entries

GSH, 10 mM, enhances heat stability

Bos taurus

-

394848

highly susceptible to proteolytic attack

Mus musculus

-

394844

insulin, 0.087 mM, decreases heat stability

Bos taurus

-

394848

metal ions required for activity and maintenance of the proper conformation of the enzyme

Rattus norvegicus

-

394815

EDTA stabilizes during purification

Rattus norvegicus

-

394820

EDTA stabilizes during purification

Bos taurus

-

394848